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Major Depressive Disorder clinical trials in Durham, NC

4 studies for Major Depressive Disorder are looking for participants at sites in and around Durham (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive Disorder

RecruitingPhase 3
  • University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Ages 12 to 17 · All sexes · Updated Nov 3, 2026 · NCT07227454

Closed-Loop Transcranial Alternating Current Stimulation for the Treatment of Major Depressive Disorder

Recruiting
  • Qortical Clinical Partners, Durham
Ages 22 and older · All sexes · Updated Oct 8, 2026 · NCT07282678

CARED : A Novel Rapid Treatment Paradigm for Depression

Recruiting
  • Carolina Center for Neurostimulation, Chapel Hill · 10 mi away
Ages 18 to 70 · All sexes · Updated Jun 25, 2026 · NCT07507370

Ovarian Hormone Withdrawal, Anhedonia, and Reward Sensitivity in Women With Premenstrual Exacerbations of Depression

RecruitingPhase 4
  • University of North Carolina, Chapel Hill, Chapel Hill · 10 mi away
Ages 18 to 45 · Women · Updated Oct 29, 2025 · NCT06610305

Major Depressive Disorder trials in other cities

Other studies in Durham

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.