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Major Depressive Disorder clinical trials in Cincinnati, OH

11 studies for Major Depressive Disorder are looking for participants at sites in and around Cincinnati (within about 30 miles). Open a study to see who can join and how to contact the study team.

A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive Disorder

RecruitingPhase 3
  • University of Cincinnati, Cincinnati
Ages 12 to 17 · All sexes · Updated Sep 25, 2026 · NCT07227454

Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder

RecruitingPhase 3
  • University of Cincinnati Medical Center, Cincinnati
Ages 18 to 65 · All sexes · Updated Sep 25, 2026 · NCT05850689

Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms

RecruitingPhase 3
  • Patient Priority Clinical Sites LLC, Cincinnati
Ages 18 to 74 · All sexes · Updated Sep 25, 2026 · NCT06559306

Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder

RecruitingPhase 3
  • Vanda Investigational Site, Cincinnati
Ages 18 to 65 · All sexes · Updated Sep 24, 2026 · NCT06830044

A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder

RecruitingPhase 3
  • Patient Priority Clinical Sites LLC, Cincinnati
Ages 18 to 74 · All sexes · Updated Aug 28, 2026 · NCT07573176

NBI-1065845-MDD3025: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, Mason · 19 mi away
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT06911112

Modulating Spinal Interoceptive Pathways to Evaluate Their Role and Therapeutic Potential in MDD Symptomatic Domains

RecruitingPhase 1/2
  • Lindner Center of Hope, Mason · 19 mi away
Ages 18 to 60 · All sexes · Updated Aug 3, 2026 · NCT06795451

Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol

RecruitingPhase 3
  • Clinical Research Site, Cincinnati
  • Clinical Research Site, Cincinnati
Ages 18 to 65 · All sexes · Updated Jul 24, 2026 · NCT07484217

Improving Outcomes in Adolescent Inpatient Depression With Deep Transcranial Magnetic Stimulation

Recruiting
  • Cincinnati Childrens Hospital Medical Center, Cincinnati
Ages 14 to 18 · All sexes · Updated Feb 11, 2026 · NCT07217444

Study of ALTO-300 in MDD

RecruitingPhase 2
  • Site 202, Cincinnati
Ages 18 to 70 · All sexes · Updated Jul 24, 2025 · NCT05922878

A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms

RecruitingPhase 4
  • Clinical Research Site, Cincinnati
Ages 18 to 65 · All sexes · Updated Jan 23, 2025 · NCT06223880

Major Depressive Disorder trials in other cities

Other studies in Cincinnati

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.