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Epilepsy clinical trials in Philadelphia, PA

11 studies for Epilepsy are looking for participants at sites in and around Philadelphia (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures FOCUS-1

RecruitingPhase 3
  • Thomas Jefferson University, Philadelphia
Ages 18 to 75 · All sexes · Updated Oct 1, 2026 · NCT07563881

Prospective Natural History Study of POLG Disease

RecruitingObservational study
  • Children's Hospital of Philadelphia-Philadelphia, Philadelphia
All ages · All sexes · Updated Sep 15, 2026 · NCT07775872

Diagnosing Epilepsy To EffeCT Change Long-Term Follow-Up

RecruitingObservational study
  • University of Pennsylvania, Philadelphia
Ages 18 to 75 · All sexes · Updated Sep 15, 2026 · NCT07110454

Diagnosing Epilepsy To EffeCT Change

Recruiting
  • University of Pennsylvania, Philadelphia
Ages 18 to 75 · All sexes · Updated Sep 15, 2026 · NCT07110337

AMT-260 Gene Therapy Study in Adults With Unilateral Refractory Mesial Temporal Lobe Epilepsy

RecruitingPhase 1/2
  • Hospital of the University of Pennsylvania, Philadelphia
Ages 18 to 75 · All sexes · Updated Aug 24, 2026 · NCT06063850

A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures

RecruitingPhase 3
  • University of Pennsylvania, Philadelphia
  • Temple University Hospital, Philadelphia
Ages 12 and older · All sexes · Updated Aug 10, 2026 · NCT05667142

A Clinical Trial of Elsunersen in Pediatric SCN2A-DEE to Assess Efficacy and Safety

RecruitingPhase 3
  • Praxis Research Site, Philadelphia
1 Day – 18 Years · All sexes · Updated Aug 3, 2026 · NCT07019922

Study of NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (EPIC (EPIlepsy Cell Therapy))

RecruitingPhase 3
  • Thomas Jefferson University Hospital, Philadelphia
Ages 18 to 75 · All sexes · Updated Jun 9, 2026 · NCT05135091

Localizing Epileptic Networks Using MRI and iEEG

RecruitingEarly phase 1Healthy volunteers welcome
  • University of Pennsylvania, Philadelphia
Ages 18 and older · All sexes · Updated Feb 13, 2026 · NCT04649008

A Long-term Study of the Safety and Effectiveness of RAP-219 in Adults With Focal Onset Seizures

RecruitingPhase 2
  • University of Pennsylvania - Department of Neurology, Philadelphia
Ages 18 to 70 · All sexes · Updated Jan 23, 2026 · NCT07219407

Epilepsy Learning Healthcare System (ELHS)

RecruitingObservational study
  • Children's Hospital of Philadelphia (CHOP), Philadelphia
All ages · All sexes · Updated Aug 30, 2024 · NCT06265103

About Epilepsy

Epilepsy is a brain disorder that causes people to have seizures. The seizures may be mild or severe. Learn about causes, diagnosis, and treatment.

More about Epilepsy on MedlinePlus

Epilepsy trials in other cities

Other studies in Philadelphia

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.