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Glioblastoma clinical trials in Philadelphia, PA

11 studies for Glioblastoma are looking for participants at sites in and around Philadelphia (within about 30 miles). Open a study to see who can join and how to contact the study team.

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Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII

RecruitingPhase 2
  • Thomas Jefferson University, Sidney Kimmel Comprehensive Cancer Center, Philadelphia
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07326566

A Study of Repotrectinib in Pediatric and Young Adult Subjects Harboring ALK, ROS1, OR NTRK1-3 Alterations

RecruitingPhase 1/2
  • Children's Hospital of Philadelphia-Center for Childhood Cancer Research, Philadelphia
Up to age 25 · All sexes · Updated Sep 25, 2026 · NCT04094610

Multitracer [18F]Fluciclovine and 18F-FDG PET, and Advanced MRI for Metabolic Profiling of Glioblastoma

RecruitingEarly phase 1
  • Hospital of the University of Pennsylvania, Philadelphia
  • University of Pennsylvania, Philadelphia
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06613841

Targeted Pediatric High-Grade Glioma Therapy

RecruitingObservational study
  • Children's Hospital of Philadelphia, Philadelphia
12 Months – 39 Years · All sexes · Updated Sep 8, 2026 · NCT05839379

Study of Olutasidenib and Temozolomide in HGG

RecruitingPhase 2
  • Children's Hospital of Philadelphia, Philadelphia
Ages 12 to 39 · All sexes · Updated Sep 1, 2026 · NCT06161974

SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance)

RecruitingPhase 3
  • Thomas Jefferson University Hospital, Philadelphia
Ages 18 and older · All sexes · Updated Aug 28, 2026 · NCT05303519

WBSI Guided Personalized Delivery of TTFields

Recruiting
  • Abramson Cancer Center, Philadelphia
  • Penn Medicine, University of Pennsylvania, Philadelphia
Ages 22 and older · All sexes · Updated Aug 6, 2026 · NCT05086497

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

RecruitingEarly phase 1Healthy volunteers welcome
  • Children's Hospital of Philadelphia, Philadelphia
Ages 1 to 21 · All sexes · Updated Jun 29, 2026 · NCT06333899

ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors

RecruitingPhase 1
  • Children's Hospital of Philadelphia, Philadelphia
Ages 2 to 21 · All sexes · Updated Jun 11, 2026 · NCT04732065

Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

RecruitingPhase 2
  • Children's Hospital of Philadelphia, Philadelphia
12 Months – 39 Years · All sexes · Updated May 29, 2026 · NCT05843253

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Philadelphia
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

Glioblastoma trials in other cities

Other studies in Philadelphia

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.