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Knee Osteoarthritis clinical trials in Chicago, IL

15 studies for Knee Osteoarthritis are looking for participants at sites in and around Chicago (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain

RecruitingPhase 2
  • Northwestern University, Chicago
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT05986292

Patient Pain and Function in Medial Knee Osteoarthritis After Anteromedial vs Anterolateral Intra-Articular Corticosteroid Injection

Recruiting
  • Hyde Park Clinic, Chicago
Ages 40 and older · All sexes · Updated Sep 4, 2026 · NCT07804446

A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Osteoarthritis Pain

RecruitingPhase 2
  • Northwestern University, Chicago
Ages 40 and older · All sexes · Updated Sep 4, 2026 · NCT07641517

A Study to Assess Safety and Tolerability of PCRX-201 in Subjects With Painful Osteoarthritis of the Knee

RecruitingPhase 2
  • Rush Medical College - Division of Rheumatology, Chicago
Ages 45 to 80 · All sexes · Updated Aug 25, 2026 · NCT06884865

Bone Marrow Aspirate Concentrate (BMAC) vs Corticosteroid Injection

Recruiting
  • Rush University Medical Center, Chicago
Ages 18 to 70 · All sexes · Updated Aug 24, 2026 · NCT05985785

Genicular Artery Embolization for Knee Osteoarthritis

Recruiting
  • Northwestern University, Chicago
Ages 40 to 80 · All sexes · Updated Jul 14, 2026 · NCT07537153

MOTION Clinical Trial

Recruiting
  • Rush University Medical Center, Chicago
All ages · All sexes · Updated Jul 14, 2026 · NCT06843980

Creation of a Prospective Data Collecting Registry for Genicular Artery Embolization for Arthritis

RecruitingObservational study
  • University of Chicago Duchossois Center for Advanced Medicine, Chicago
Ages 18 and older · All sexes · Updated May 13, 2026 · NCT06781463

ROAM OA: Functional and Patient Reported Outcomes Wearing a Knee Brace for Unicompartmental OA

Recruiting
  • Rush University Medical Center, Chicago
Ages 40 to 85 · All sexes · Updated May 12, 2026 · NCT07224958

Brain-Based and Clinical Phenotyping of Pain Pharmacotherapy in Knee Osteoarthritis

RecruitingPhase 4
  • Northwestern University, Chicago
Ages 41 and older · All sexes · Updated Apr 30, 2026 · NCT06245109

A Study to Evaluate the Efficacy and Safey of PTP-001 (MOTYS™) in Knee Osteoarthritis Patients

RecruitingPhase 3
  • Chicago Clinical Research Institute, Inc., Chicago
Ages 40 to 80 · All sexes · Updated Apr 29, 2026 · NCT07219771

Mechanical Alignment vs Kalipered Kinematic Alignment Total Knee Arthroplasty

Recruiting
  • Northwestern Medicine, Chicago
Ages 21 to 79 · All sexes · Updated Mar 24, 2026 · NCT06617871

Investigating Patient Satisfaction With Smart Knee Implants

RecruitingHealthy volunteers welcome
  • The University of Chicago Medical Center, Chicago
Ages 18 and older · All sexes · Updated Dec 17, 2025 · NCT06968143

Ischemic Preconditioning in Osteoarthritis and Back Pain

Recruiting
  • Human and Sport Performance Lab, Chicago
Ages 50 and older · All sexes · Updated Nov 17, 2025 · NCT07003113

Genicular Artery Embolization for Reducing Pain in Medically Refractory Symptomatic Knee Osteoarthritis

RecruitingPhase 2
  • University of Chicago, Chicago
Ages 40 to 80 · All sexes · Updated May 15, 2025 · NCT06859164

Knee Osteoarthritis trials in other cities

Other studies in Chicago

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.