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Major Depressive Disorder clinical trials in San Jose, CA

7 studies for Major Depressive Disorder are looking for participants at sites in and around San Jose (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms

RecruitingPhase 3
  • Lumos Clinical Research Center LLC, San Jose
Ages 18 to 74 · All sexes · Updated Sep 25, 2026 · NCT06559306

Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder

RecruitingPhase 3
  • Vanda Investigational Site, San Jose
Ages 18 to 65 · All sexes · Updated Sep 24, 2026 · NCT06830044

A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)

RecruitingPhase 2
  • Seaport Investigator Site, San Jose
Ages 18 to 65 · All sexes · Updated Sep 14, 2026 · NCT07065240

A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder

RecruitingPhase 2
  • Lumos Clinical Research Center, San Jose
Ages 18 to 64 · All sexes · Updated Jul 27, 2026 · NCT07115329

Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, San Jose
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT06966401

A Study to Evaluate the Maintenance Effect of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, San Jose
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT07196501

Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder (AMPLIFY)

RecruitingPhase 2
  • Autobahn Site #119, San Jose
Ages 18 to 65 · All sexes · Updated Jan 20, 2026 · NCT06633016

Major Depressive Disorder trials in other cities

Other studies in San Jose

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.