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Crohn's Disease clinical trials in Orlando, FL

17 studies for Crohn's Disease are looking for participants at sites in and around Orlando (within about 30 miles). Open a study to see who can join and how to contact the study team.

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A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)

RecruitingPhase 3
  • AdventHealth Orlando ( Site 5131), Orlando
  • Endoscopic Research Inc ( Site 5061), Orlando
Ages 16 to 80 · All sexes · Updated Oct 2, 2026 · NCT06430801

Study of Advanced Therapies for the Treatment of Adult Participants With Moderately to Severely Active Crohn's Disease or Ulcerative Colitis

RecruitingPhase 2
  • Digestive And Liver Center Of Florida - Orlando /ID# 280924, Orlando
  • Clinical Research of Osceola /ID# 280593, Kissimmee · 16 mi away
Ages 18 to 75 · All sexes · Updated Oct 2, 2026 · NCT07697456

A Study of Vedolizumab in Adults With Ulcerative Colitis (UC) or Crohn's Disease (CD) in the Community Setting

RecruitingPhase 4
  • Endoscopic Research, Inc., Orlando
  • Orlando Health-Orlando Regional Medical Center, Orlando
  • Digestive and Liver Center of Florida, P.A., Kissimmee · 16 mi away
Ages 18 to 80 · All sexes · Updated Sep 30, 2026 · NCT06581328

Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease

RecruitingPhase 2
  • Endoscopic Research, Inc. /ID# 267211, Orlando
  • Novum Research /ID# 278128, Clermont · 24 mi away
Ages 18 to 75 · All sexes · Updated Sep 25, 2026 · NCT06548542

A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Crohn's Disease

RecruitingPhase 2
  • AdventHealth (Florida Hospital) Medical Group, Orlando
Ages 18 to 75 · All sexes · Updated Sep 25, 2026 · NCT06233461

Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight

RecruitingPhase 3
  • Orlando Health, Orlando
  • Digestive and Liver Center of Florida, Orlando
Ages 18 to 70 · All sexes · Updated Sep 24, 2026 · NCT06937099

An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease

RecruitingPhase 3
  • AdventHealth Orlando-Site Number: 8400070, Orlando
  • Orlando Health, Inc.-Site Number: 8400084, Orlando
  • Clinical Research of Osceola-Site Number: 8400013, Kissimmee · 16 mi away
  • and 1 more
Ages 16 to 80 · All sexes · Updated Sep 23, 2026 · NCT07184931

A Maintenance Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease

RecruitingPhase 3
  • Orlando Health, Inc., Digestive Health Institute-Site Number: 8400084, Orlando
  • Clinical Research of Osceola-Site Number: 8400013, Kissimmee · 16 mi away
Ages 16 to 80 · All sexes · Updated Sep 23, 2026 · NCT07184944

A Study to Assess Adverse Events, Change in Disease Activity, and How Intravenous and Subcutaneous Risankizumab Moves Through the Body of Pediatric Participants With Moderately to Severely Active Crohn's Disease

RecruitingPhase 3
  • Arnold Palmer Hospital for Children Center Digestive Health and Nutrition-Orland /ID# 255437, Orlando
Ages 2 to 17 · All sexes · Updated Sep 23, 2026 · NCT05995353

A Phase 2 Study to Evaluate MORF-057 in Adults With Moderately to Severely Active Crohn's Disease

RecruitingPhase 2
  • Endoscopic Research Inc, Orlando
  • Clinical Research of Osceola, Kissimmee · 16 mi away
Ages 18 to 85 · All sexes · Updated Sep 22, 2026 · NCT06226883

A Study of Vedolizumab Intravenous (IV) and Adalimumab or Vedolizumab and Ustekinumab in Adults With Crohn's Disease

RecruitingPhase 4
  • Endoscopic Research Inc, Orlando
  • Clinical Research of Osceola, Kissimmee · 16 mi away
Ages 18 to 70 · All sexes · Updated Sep 9, 2026 · NCT06045754

Treat-to-Target of Endoscopic Remission in Patients With IBD in Symptomatic Remission

Recruiting
  • Advent Health, Orlando
Ages 18 and older · All sexes · Updated Aug 7, 2026 · NCT05230173

Zymfentra (Infliximab-dyyb) REal World Cohort STudy

RecruitingObservational study
  • AdventHealth, Orlando
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT07237516

Open-label Single-arm Study to Assess the Efficacy of Mirikizumab in Patients With Inflammatory Strictures Due to CD

RecruitingPhase 4
  • Digestive & Liver Center of Florida, Orlando
Ages 18 and older · All sexes · Updated Jul 16, 2026 · NCT06997965

Efficacy and Safety of Obefazimod in Subjects With Moderately to Severely Active Crohn's Disease

RecruitingPhase 2
  • Orlando Health, Inc., Orlando
Ages 18 to 75 · All sexes · Updated Apr 27, 2026 · NCT06456593

A Study to Investigate Efficacy and Safety of SAR442970 in Patients With Crohn's Disease

RecruitingPhase 2
  • Investigational Site Number: 8400007, Orlando
  • Investigational Site Number: 8400017, Kissimmee · 16 mi away
Ages 18 to 75 · All sexes · Updated Mar 27, 2026 · NCT06958536

A Phase 2 Study to Evaluate Therapies for Inflammatory Bowel Disease

RecruitingPhase 2
  • Mirador Therapeutics Selected Site, Orlando
Ages 18 to 80 · All sexes · Updated Mar 12, 2026 · NCT07113522

About Crohn's Disease

Crohn's Disease can cause inflammation in any area from the mouth to the anus. Read about medicines, surgery or dietary management to treat symptoms.

More about Crohn's Disease on MedlinePlus

Crohn's Disease trials in other cities

Other studies in Orlando

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.