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Brain Tumors clinical trials in Boston, MA

28 studies for Brain Tumors are looking for participants at sites in and around Boston (within about 30 miles). Open a study to see who can join and how to contact the study team.

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Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII

RecruitingPhase 2
  • Massachusetts General Hospital, Boston
  • Beth Israel Deaconess Medical Center, Boston
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07326566

Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis

RecruitingPhase 1/2
  • Tufts Medical Center, Boston
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06047379

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

RecruitingPhase 1/2
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT05786924

A Study of BMS-986504 Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)

RecruitingPhase 2
  • Local Institution - 0124, Boston
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT07492680

A Phase 1/1b Study of IAM1363 in HER2 Cancers

RecruitingPhase 1
  • Massachusetts General Hospital, Boston
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06253871

Treatment Response Assessment Maps to Delineate Necrosis From Tumor After Stereotactic Radiation in Brain Metastases

Recruiting
  • Brigham and Women's Hospital, Boston
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT04033497

Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases

RecruitingPhase 2
  • Brigham and Women's Hospital, Boston
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT04899908

Study of Abemaciclib and Elacestrant in Participants With Brain Metastasis Due to ER+/HER-2- Breast Cancer

RecruitingPhase 1/2
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT05386108

Targeted Pediatric High-Grade Glioma Therapy

RecruitingObservational study
  • Dana-Farber Cancer Institute, Boston
12 Months – 39 Years · All sexes · Updated Sep 8, 2026 · NCT05839379

A Study of Zanzalintinib in Participants With Recurrent or Progressive Meningioma

RecruitingPhase 2
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT07428616

Stereotactic Radiation for Growing/Changing Brain Metastases With Same-Day Radiation Planning and Treatment With Margin Reduction

RecruitingPhase 2
  • Brigham and Women's Hospital / Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT07132190

Prophylactic Anti-Seizure Medication vs No Anti-Seizure Medication for Patients With Primary Motor Cortex Brain Metastases

RecruitingPhase 2
  • Brigham and Women's Hospital, Boston
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT07130786

B7-H3.CD28Z.CART in CNS Neoplasms

RecruitingPhase 1
  • Boston Children's Hospital, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 2 to 21 · All sexes · Updated Sep 3, 2026 · NCT07390539

Study of Olutasidenib and Temozolomide in HGG

RecruitingPhase 2
  • Susan Chi, Boston
Ages 12 to 39 · All sexes · Updated Sep 1, 2026 · NCT06161974

Local Control, Quality of Life and Toxicities in Adults With Benign or Indolent Brain Tumors Undergoing Proton Radiation Therapy

Recruiting
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated Aug 24, 2026 · NCT03286335

Registry of Patients With Brain Tumors Treated With STaRT (GammaTiles)

RecruitingObservational study
  • Beth Israel Deaconess Medical Center, Boston
  • Beth Israel Deaconess Medical Center, Boston
All ages · All sexes · Updated Jul 22, 2026 · NCT04427384

Palbociclib and Pembrolizumab In Central Nervous System Metastases

RecruitingPhase 2
  • Massachusetts General Hospital, Boston
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Jul 21, 2026 · NCT02896335

Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases

RecruitingPhase 3
  • Tufts Medical Center, Boston
Ages 18 and older · All sexes · Updated Jun 9, 2026 · NCT03550391

Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

RecruitingPhase 2
  • Dana-Farber Cancer Institute, Boston
12 Months – 39 Years · All sexes · Updated May 29, 2026 · NCT05843253

NTS-WBRT in Brain Metastases

RecruitingPhase 2
  • Massachusetts General Hospital Cancer Center, Boston
Ages 18 and older · All sexes · Updated Apr 16, 2026 · NCT05013892

Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss

RecruitingPhase 1/2
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Apr 13, 2026 · NCT06810544

NeuroPathways Intervention for Brain Tumor Patients

Recruiting
  • Massachusetts General Hospital Cancer Center, Boston
Ages 18 and older · All sexes · Updated Dec 17, 2025 · NCT05976490

Stereotactic Magnetic Resonance Guided Radiation Therapy

Recruiting
  • Brigham & Women's Hospital, Boston
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Nov 13, 2025 · NCT04115254

A Surgical Window of Opportunity Clinical Trial of Troriluzole in Recurrent IDH Wild-Type Glioblastoma

RecruitingEarly phase 1
  • Brigham and Women's Hospital, Boston
  • Dana-Farber Cancer Institute, Boston
  • Massachusetts General Hospital Cancer Center, Boston
Ages 18 and older · All sexes · Updated Sep 11, 2025 · NCT06552260

A Study of PARP1 Selective Inhibitor, EIK1004 (IMP1707) in Participants With Advanced Solid Tumors.

RecruitingPhase 1/2
  • Beth Israel Deaconess Medical Center, Boston
Ages 18 to 89 · All sexes · Updated Aug 19, 2025 · NCT06907043

ASCENT Intervention for Brain Tumor Patients

Recruiting
  • Massachusetts General Hospital Cancer Center, Boston
Ages 18 and older · All sexes · Updated Jul 14, 2025 · NCT06099743

The RECMAP-study: Resection With or Without Intraoperative Mapping for Recurrent Glioblastoma

RecruitingObservational study
  • Massachusetts General Hospital, Boston
Up to age 90 · All sexes · Updated Feb 22, 2024 · NCT06273176

The SUPRAMAX Study: Supramaximal Resection Versus Maximal Resection for High-Grade Glioma Patients (ENCRAM 2201)

RecruitingObservational study
  • Massachusetts General Hospital, Boston
Ages 18 to 90 · All sexes · Updated Feb 22, 2024 · NCT06118723

About Brain Tumors

A brain tumor is a growth of abnormal cells in the brain tissue. Learn the types of tumors, symptoms, how they are diagnosed and treatment options.

More about Brain Tumors on MedlinePlus

Brain Tumors trials in other cities

Other studies in Boston

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.