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Heart Failure clinical trials in Charlotte, NC

11 studies for Heart Failure are looking for participants at sites in and around Charlotte (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function

RecruitingPhase 3
  • Research Site, Charlotte
Ages 18 to 130 · All sexes · Updated Oct 2, 2026 · NCT06307652

Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin

RecruitingPhase 3
  • Research Site, Charlotte
  • Research Site, Fort Mill · 16 mi away
  • Research Site, Monroe · 24 mi away
Ages 40 and older · All sexes · Updated Sep 15, 2026 · NCT06677060

A Study to Determine the Efficacy and Safety of Finerenone and SGLT2i in Combination in Hospitalized Patients With Heart Failure (CONFIRMATION-HF)

RecruitingPhase 3
  • CON-10318, Charlotte, NC, Charlotte
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06024746

Safety and Effectiveness of Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart Failure

Recruiting
  • Sanger Heart and Vascular Institute, Charlotte
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT07069738

Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure

Recruiting
  • Atrium Health Sanger Heart and Vascular Institute, Charlotte
Ages 21 and older · All sexes · Updated Aug 25, 2026 · NCT05677100

A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity

RecruitingPhase 3
  • Piedmont Research Partners, LLC, Fort Mill · 16 mi away
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07567001

CAPACITY (Cardiac Amyloidosis and Physical ACtivITY) Study

Recruiting
  • Sanger Heart and Vascular Institute, Charlotte
Ages 18 and older · All sexes · Updated Jul 21, 2026 · NCT06096675

Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure

Recruiting
  • Carolinas Medical Center, Charlotte
Ages 18 and older · All sexes · Updated Jun 10, 2026 · NCT06526195

Left vs Left Randomized Clinical Trial

Recruiting
  • Novant Health, Charlotte
Ages 18 and older · All sexes · Updated Oct 2, 2025 · NCT05650658

About Heart Failure

Heart failure, or congestive heart failure (CHF), means the heart can't pump enough blood. Learn about the signs, symptoms, and causes.

More about Heart Failure on MedlinePlus

Heart Failure trials in other cities

Other studies in Charlotte

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.