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Prostate Cancer clinical trials in Pittsburgh, PA

23 studies for Prostate Cancer are looking for participants at sites in and around Pittsburgh (within about 30 miles). Open a study to see who can join and how to contact the study team.

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The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
  • University of Pittsburgh Medical Center, Pittsburgh
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750

Testing the Addition of Docetaxel (Chemotherapy) to the Usual Treatment (Hormonal Therapy and Apalutamide) for Metastatic Prostate Cancer, ASPIRE Trial

RecruitingPhase 3
  • Allegheny General Hospital, Pittsburgh
  • West Penn Hospital, Pittsburgh
  • Jefferson Hospital, Jefferson Hills · 11 mi away
  • and 3 more
Ages 18 and older · Men · Updated Oct 2, 2026 · NCT06931340

Distance-Based Exercise to Preserve Function and Prevent Disability

Recruiting
  • UPMC Hillman Cancer Center, Pittsburgh
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT07059884

Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

RecruitingPhase 2
  • UPMC Hillman Cancer Center, Pittsburgh
  • UPMC-Passavant Hospital, Pittsburgh
  • UPMC-Saint Clair Hospital Cancer Center, Pittsburgh
  • and 2 more
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT03866382

A Study of LY4257496 in Participants With Cancer (OMNIRAY)

RecruitingPhase 1
  • University of Pittsburgh Medical Center, Pittsburgh
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07114601

A Study of Xaluritamig Plus Abiraterone Versus Investigator's Choice in Participants With Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer

RecruitingPhase 3
  • University of Pittsburgh Medical Center, Pittsburgh
Ages 18 and older · Men · Updated Sep 22, 2026 · NCT07213674

A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation

RecruitingPhase 3
  • Research Site, Pittsburgh
Ages 18 and older · Men · Updated Sep 18, 2026 · NCT06952803

Trial of Xaluritamig in Adults With Metastatic Castration-resistant Prostate Cancer

RecruitingPhase 1
  • University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh
Ages 18 and older · Men · Updated Sep 15, 2026 · NCT07493512

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

RecruitingPhase 3
  • UPMC-Magee Womens Hospital, Pittsburgh
  • UPMC-Saint Margaret, Pittsburgh
  • University of Pittsburgh Cancer Institute (UPCI), Pittsburgh
  • and 6 more
Ages 18 and older · Men · Updated Sep 10, 2026 · NCT05946213

AZD2265 Compared With Standard of Care in PSMA-positive Metastatic Castration-resistant Prostate Cancer (VECTRA-01)

RecruitingPhase 3
  • Research Site, Pittsburgh
Ages 18 and older · Men · Updated Aug 26, 2026 · NCT07611110

Study of AMG 509 in Participants With Metastatic Castration-Resistant Prostate Cancer

RecruitingPhase 1
  • University of Pittsburgh Medical Center, Pittsburgh
Ages 18 and older · Men · Updated Aug 21, 2026 · NCT04221542

Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging

RecruitingPhase 3
  • UPMC-Magee Womens Hospital, Pittsburgh
  • UPMC-Saint Margaret, Pittsburgh
  • UPMC Hillman Cancer Center, Pittsburgh
  • and 9 more
Ages 18 and older · Men · Updated Aug 19, 2026 · NCT04423211

FOG-001 in Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
  • University of Pittsburgh Medical Center, Hillman Cancer Center, Pittsburgh
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT05919264

Study of JANX007 in Subjects With Metastatic Castration-Resistant Prostate Cancer (ENGAGER-PSMA-01)

RecruitingPhase 1
  • UPMC Hillman Cancer Center, Pittsburgh
Ages 18 to 100 · Men · Updated Aug 13, 2026 · NCT05519449

Study Evaluating the Safety, Tolerability, and Efficacy of Xaluritamig in Combination With Androgen Receptor Pathway Inhibitors in Participants With Metastatic Hormone-sensitive Prostate Cancer

RecruitingPhase 1
  • University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh
Ages 18 and older · Men · Updated Jul 2, 2026 · NCT07140900

Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors

RecruitingPhase 1
  • University of Pittsburg Medical Center (UPCM), Pittsburgh
Ages 18 and older · All sexes · Updated Jun 11, 2026 · NCT05283330

Study of CX-5461 in Patients With Solid Tumours and BRCA1/2, PALB2 or Homologous Recombination Deficiency (HRD) Mutation

RecruitingPhase 1
  • UPMC Hillman Cancer Center, Pittsburgh
Ages 18 and older · All sexes · Updated Jun 8, 2026 · NCT04890613

Long-Term Safety of Lutetium (177Lu) Vipivotide Tetraxetan in Participants With Prostate Cancer

RecruitingPhase 4
  • Univ of Pittsburgh Medical Center, Pittsburgh
Ages 18 to 100 · Men · Updated Jun 4, 2026 · NCT05803941

TERPS Trial for de Novo Oligometastic Prostate Cancer

RecruitingPhase 2
  • UPMC Hillman Cancer Center, Pittsburgh
Ages 18 and older · Men · Updated Jun 3, 2026 · NCT05223803

Androgen Suppression Combined With Nodal Irradiation and Dose Escalated Prostate Treatment

RecruitingPhase 3
  • Allegheny General Hospital, Pittsburgh
  • West Penn Hospital, Pittsburgh
  • Jefferson Hospital, Jefferson Hills · 11 mi away
  • and 2 more
Ages 18 and older · Men · Updated Apr 14, 2026 · NCT06235697

The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study

RecruitingObservational study
  • Allegheny Health Network, Pittsburgh
Ages 18 and older · All sexes · Updated Mar 5, 2026 · NCT04075305

Circulating Tumor DNA in High Risk Localized Prostate Cancer

RecruitingObservational study
  • UPMC Hillman Cancer Center, Pittsburgh
Ages 18 and older · Men · Updated Oct 29, 2025 · NCT07222436

Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer

RecruitingPhase 3
  • University of Pittsburgh Cancer Institute (UPCI), Pittsburgh
  • UPMC-Shadyside Hospital, Pittsburgh
Ages 18 and older · Men · Updated Sep 11, 2025 · NCT03678025

About Prostate Cancer

Prostate cancer is one of the most common types of cancer among American men. The risk goes up as men age. Learn about symptoms, tests, and treatment.

More about Prostate Cancer on MedlinePlus

Prostate Cancer trials in other cities

Other studies in Pittsburgh

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.