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Heart Diseases clinical trials in Cleveland, OH

13 studies for Heart Diseases are looking for participants at sites in and around Cleveland (within about 30 miles). Open a study to see who can join and how to contact the study team.

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Transition to KPL-387 Monotherapy Dosing & Administration Study

RecruitingPhase 2
  • Investigational Site 040, Cleveland
Ages 18 to 80 · All sexes · Updated Sep 30, 2026 · NCT07288216

Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

Recruiting
  • University Hospitals Cleveland Medical Center, Cleveland
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT03242642

Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure

Recruiting
  • Cleveland Clinic, Cleveland
Ages 18 to 100 · All sexes · Updated Sep 9, 2026 · NCT06310031

Safety and Performance Assessment of the Sphere-9™ Catheter and Affera™ Ablation System for the Treatment of Ventricular Tachycardia (Sphere-9 VT EFS)

Recruiting
  • Cleveland Clinic Foundation, Cleveland
Ages 18 to 85 · All sexes · Updated Sep 3, 2026 · NCT06703489

Abbott Structural Heart Device Registry

RecruitingObservational study
  • The Cleveland Clinic Foundation, Cleveland
All ages · All sexes · Updated Sep 1, 2026 · NCT06590467

Randomization of Single vs Multiple Arterial Grafts

Recruiting
  • Cleveland Clinic Foundation, Cleveland
Ages 18 to 70 · All sexes · Updated Aug 20, 2026 · NCT03217006

Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant

RecruitingPhase 3
  • Cleveland Clinic, Cleveland
Ages 18 to 75 · All sexes · Updated Aug 4, 2026 · NCT06563895

PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III

Recruiting
  • University Hospital (Cleveland), Cleveland
Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT05934487

Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure

Recruiting
  • The Cleveland Clinic Foundation, Cleveland
Ages 18 and older · All sexes · Updated Jun 10, 2026 · NCT06526195

Sternal Plating High Risk

Recruiting
  • University Hospitals, Cleveland
Ages 18 to 89 · All sexes · Updated Apr 30, 2026 · NCT06660186

The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR

Recruiting
  • Cleveland Clinic, Cleveland
Ages 18 and older · All sexes · Updated Apr 13, 2026 · NCT03142152

Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women

Recruiting
  • Cleveland Clinic Foundation, Cleveland
Ages 18 and older · Women · Updated Apr 1, 2026 · NCT04124120

PARTNER 3 Trial - Aortic Valve-in-Valve

Recruiting
  • The Cleveland Clinic Foundation, Cleveland
All ages · All sexes · Updated May 10, 2024 · NCT03003299

About Heart Diseases

Heart disease is the leading cause of death in the U.S. Learn about the different types of heart diseases, and what you can do to try to prevent them.

More about Heart Diseases on MedlinePlus

Heart Diseases trials in other cities

Other studies in Cleveland

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.