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Major Depressive Disorder clinical trials in Baltimore, MD

9 studies for Major Depressive Disorder are looking for participants at sites in and around Baltimore (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder

RecruitingPhase 3
  • Pharmasite Research, Inc., Baltimore
Ages 18 to 75 · All sexes · Updated Oct 1, 2026 · NCT07775300

A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder

RecruitingPhase 3
  • Pharmasite Research, Inc., Baltimore
Ages 18 to 74 · All sexes · Updated Oct 1, 2026 · NCT07573176

A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive Disorder

RecruitingPhase 3
  • Johns Hopkins University, Baltimore
Ages 12 to 17 · All sexes · Updated Sep 25, 2026 · NCT07227454

Defining Neurobiological Links Between Substance Use and Mental Illness

RecruitingHealthy volunteers welcome
  • National Institute on Drug Abuse, Baltimore
Ages 18 to 60 · All sexes · Updated Sep 11, 2026 · NCT05538910

A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3)

RecruitingPhase 3
  • Pharmasite Research Inc., Baltimore
Ages 18 to 74 · All sexes · Updated Sep 8, 2026 · NCT07076407

A Study of Brenipatide in Adult Participants With Major Depressive Disorder

RecruitingPhase 3
  • Pharmasite Research, Inc., Baltimore
Ages 18 to 75 · All sexes · Updated Aug 6, 2026 · NCT07412756

A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder

RecruitingPhase 2
  • Continental Clinical Solutions, Towson · 8 mi away
Ages 18 to 64 · All sexes · Updated Jul 27, 2026 · NCT07115329

Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol

RecruitingPhase 3
  • Clinical Research Site, Pikesville · 8 mi away
Ages 18 to 65 · All sexes · Updated Jul 24, 2026 · NCT07484217

A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)

RecruitingPhase 2
  • Sheppard Pratt, Baltimore
Ages 18 to 65 · All sexes · Updated May 11, 2026 · NCT06524830

Major Depressive Disorder trials in other cities

Other studies in Baltimore

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.