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Glioblastoma clinical trials in Rochester, MN

13 studies for Glioblastoma are looking for participants at sites in and around Rochester (within about 30 miles). Open a study to see who can join and how to contact the study team.

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GI-102 Alone or With Pembrolizumab Before Surgery for Treatment of Recurrent or Progressive IDH Wildtype Glioblastoma and IDH Mutated Grade 4 Astrocytoma

RecruitingPhase 2
  • Mayo Clinic in Rochester, Rochester
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT07301268

Testing the Addition of an Anti-cancer Drug, Selinexor, to the Usual Chemotherapy Treatment (Temozolomide) for Brain Tumors That Have Returned After Previous Treatment

RecruitingPhase 1/2
  • Mayo Clinic in Rochester, Rochester
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT05432804

SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance)

RecruitingPhase 3
  • Mayo Clinic - Rochester, Rochester
Ages 18 and older · All sexes · Updated Aug 28, 2026 · NCT05303519

Sonodynamic Therapy With SONALA-001 or 5-ALA HCL and Magnetic Resonance Guided Focused Ultrasound for the Treatment of Progressive or Recurrent Glioblastoma

RecruitingEarly phase 1
  • Mayo Clinic in Rochester, Rochester
Ages 18 and older · All sexes · Updated Aug 25, 2026 · NCT07076472

Feasibility of Intra- and Post-operative Microdialysis During Neurosurgery for Central Nervous System Lesions

Recruiting
  • Mayo Clinic in Rochester, Rochester
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT04047264

Continuous Glucose Monitoring for the Management of Hyperglycemia in Patients With Glioblastoma

Recruiting
  • Mayo Clinic in Rochester, Rochester
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT07091864

A Digital Treatment Platform for the Delivery of Home-Based Sequential Therapy in Patients With Glioma, GHoST Trial

Recruiting
  • Mayo Clinic in Rochester, Rochester
Ages 18 and older · All sexes · Updated Aug 10, 2026 · NCT07074756

Adjuvant Temozolomide ± 5-Aminolevulinic Acid + Low Intensity Diffuse Ultrasound Sonodynamic Therapy System for Newly Diagnosed Glioblastoma

RecruitingPhase 2
  • Mayo Clinic, Rochester
Ages 18 to 80 · All sexes · Updated Jul 17, 2026 · NCT07225621

Retifanlimab With or Without Difluoromethylornithine for the Treatment of Progressive High Grade Gliomas

RecruitingPhase 1/2
  • Mayo Clinic in Rochester, Rochester
Ages 18 and older · All sexes · Updated Jun 24, 2026 · NCT07468136

ATM-Inhibitor WSD0628 in Combination With Radiation Therapy for Treatment of Recurrent High-Grade Glioma

RecruitingPhase 1
  • Mayo Clinic in Rochester, Rochester
Ages 18 and older · All sexes · Updated Apr 21, 2026 · NCT05917145

A Phase 1/2 Study of the Safety and Tolerability of MT-125 in GBM Patients

RecruitingPhase 1/2
  • Mayo Clinic Hospital, Rochester
Ages 18 and older · All sexes · Updated Apr 14, 2026 · NCT07185880

Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss

RecruitingPhase 1/2
  • Mayo Clinic Cancer Center, Rochester
Ages 18 and older · All sexes · Updated Apr 13, 2026 · NCT06810544

Retifanlimab with Bevacizumab and Hypofractionated Radiotherapy for the Treatment of Recurrent Glioblastoma

RecruitingPhase 2
  • Mayo Clinic, Rochester
Ages 18 and older · All sexes · Updated Nov 19, 2024 · NCT06160206

Glioblastoma trials in other cities

Other studies in Rochester

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.