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Major Depressive Disorder clinical trials in Oklahoma City, OK

9 studies for Major Depressive Disorder are looking for participants at sites in and around Oklahoma City (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder

RecruitingPhase 3
  • Sooner Clinical Research, Oklahoma City
Ages 18 to 74 · All sexes · Updated Oct 1, 2026 · NCT07573176

A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3)

RecruitingPhase 3
  • Sooner Clinical Research, Oklahoma City
Ages 18 to 74 · All sexes · Updated Sep 8, 2026 · NCT07076407

A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder

RecruitingPhase 3
  • Pahl Pharmaceutical Professionals Llc, Oklahoma City
Ages 18 to 74 · All sexes · Updated Aug 3, 2026 · NCT06775379

Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol

RecruitingPhase 3
  • Clinical Research Site, Oklahoma City
Ages 18 to 65 · All sexes · Updated Jul 24, 2026 · NCT07484217

A Study to Evaluate the Maintenance Effect of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, Oklahoma City
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT07196501

A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder

RecruitingPhase 2
  • Sooner Clinical Research /ID# 277659, Oklahoma City
Ages 18 to 65 · All sexes · Updated Jun 15, 2026 · NCT07276997

Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder (AMPLIFY)

RecruitingPhase 2
  • Autobahn Site #107, Oklahoma City
Ages 18 to 65 · All sexes · Updated Jan 20, 2026 · NCT06633016

Study of ALTO-300 in MDD

RecruitingPhase 2
  • Site 195, Oklahoma City
Ages 18 to 70 · All sexes · Updated Jul 24, 2025 · NCT05922878

A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms

RecruitingPhase 4
  • Clinical Research Site, Oklahoma City
Ages 18 to 65 · All sexes · Updated Jan 23, 2025 · NCT06223880

Major Depressive Disorder trials in other cities

Other studies in Oklahoma City

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.