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Melanoma clinical trials in Irvine, CA

6 studies for Melanoma are looking for participants at sites in and around Irvine (within about 30 miles). Open a study to see who can join and how to contact the study team.

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BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

RecruitingPhase 2
  • UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT05136196

Comparing the Effectiveness of Less Invasive Procedures With the Current Standard of Care for the Treatment of Older Adults With Early-Stage Melanoma

RecruitingPhase 3
  • UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine
Ages 75 and older · All sexes · Updated Sep 24, 2026 · NCT07068074

Positron Emission Tomography (PET) Guided Stereotactic Body Radiation Therapy for the Treatment of Oligoprogressive Non-small Cell Lung Cancer, Melanoma, and Renal Cell Carcinoma

RecruitingPhase 2
  • City of Hope at Irvine Lennar, Irvine
Ages 18 and older · All sexes · Updated Aug 31, 2026 · NCT05830058

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Irvine
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

Safety, Tolerability, and Preliminary Efficacy of CJRB-101 With Pembrolizumab in Subjects With Selected Types of Advanced or Metastatic Cancer

RecruitingPhase 1/2
  • University of California, Irvine, Irvine
Ages 18 and older · All sexes · Updated Dec 20, 2024 · NCT05877430

Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma

Recruiting
  • UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine
Ages 18 and older · All sexes · Updated Nov 27, 2024 · NCT03860883

About Melanoma

Melanoma is the most serious type of skin cancer. Most have a black or black-blue area. Learn the 'ABCDE' of what to watch for and treatment options.

More about Melanoma on MedlinePlus

Melanoma trials in other cities

Other studies in Irvine

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.