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Head and Neck Cancer clinical trials in Philadelphia, PA

9 studies for Head and Neck Cancer are looking for participants at sites in and around Philadelphia (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
  • Abramson Cancer Center of the University of Pennsylvania, Philadelphia
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750

DESTINY-PANTUMOUR04

RecruitingObservational study
  • Research Site, Philadelphia
Ages 18 to 130 · All sexes · Updated Sep 25, 2026 · NCT07124000

A Pilot Study of Ultra-High Dose Rate (ConformalFLASH®), for Reirradiation of Carcinoma of the Head and Neck

Recruiting
  • The University of Pennsylvania, Department of Radiation Oncology, Philadelphia
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT07644585

Self-Management for Head and Neck Lymphedema and Fibrosis [PROMISE Trial]

Recruiting
  • University of Pennsylvania, Philadelphia
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT06125743

Implementing the NYU Electronic Patient Visit Assessment (ePVA) for Head and Neck Cancer In Rural and Urban Populations

Recruiting
  • Fox Chase Cancer Center, Philadelphia
Ages 18 and older · All sexes · Updated Jul 6, 2026 · NCT06030011

Photobiomodulation in Head and Neck Cancer-Related Chronic Lymphedema

Recruiting
  • University of Pennsylvania Abramson Cancer Center, Philadelphia
Ages 18 and older · All sexes · Updated Jun 23, 2026 · NCT06837480

A Study of Dostarlimab vs Placebo After Chemoradiation in Adult Participants With Locally Advanced Unresected Head and Neck Squamous Cell Carcinoma

RecruitingPhase 3
  • GSK Investigational Site, Philadelphia
Ages 18 and older · All sexes · Updated May 26, 2026 · NCT06256588

Pembrolizumab Plus Ultrasound-Induced Microbubble Cavitation in Head and Neck Cancer

RecruitingPhase 1
  • Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University, Philadelphia
Ages 18 and older · All sexes · Updated Mar 30, 2026 · NCT07501650

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Philadelphia
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

About Head and Neck Cancer

Head and neck cancer includes cancers of the mouth, nose, sinuses, salivary glands, throat, and lymph nodes. Read the different symptoms of each type.

More about Head and Neck Cancer on MedlinePlus

Head and Neck Cancer trials in other cities

Other studies in Philadelphia

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.