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Alzheimer's Disease clinical trials in Boston, MA

26 studies for Alzheimer's Disease are looking for participants at sites in and around Boston (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Dominantly Inherited Alzheimer Network (DIAN)

RecruitingObservational studyHealthy volunteers welcome
  • Brigham and Women's Hospital, Boston
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT00869817

Improving Memory in Alzheimer's Disease With Noninvasive Brain Stimulation

RecruitingHealthy volunteers welcome
  • 111 Cummington Mall. Room 264, Boston
Ages 50 to 100 · All sexes · Updated Sep 23, 2026 · NCT06094192

A Study of Donanemab (LY3002813) in Participants With Early Cognitive Decline (TRAILBLAZER-ALZ 7)

RecruitingPhase 2
  • Massachusetts General Hospital - Charlestown, Charlestown · 1 mi away
Ages 55 to 85 · All sexes · Updated Sep 22, 2026 · NCT07589595

A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)

RecruitingPhase 3
  • Tufts Medical Center - 800 Washington St - PPDS, Boston
Ages 55 to 90 · All sexes · Updated Sep 22, 2026 · NCT06585787

Study of LHP588 in Subjects With P. Gingivalis-Positive Alzheimer's Disease

RecruitingPhase 2
  • Adams Clinical Boston, Boston
Ages 55 to 80 · All sexes · Updated Sep 21, 2026 · NCT06847321

Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies

RecruitingPhase 3
  • Adams Clinical Boston, Boston
Ages 50 to 90 · All sexes · Updated Sep 21, 2026 · NCT07177352

Tau PET/CT Imaging in the Mismatch Prospective Cohort Study (MPC-TAU)

RecruitingObservational study
  • Massachusetts General Hospital, Boston
Ages 18 to 120 · All sexes · Updated Sep 4, 2026 · NCT05658913

Contributions of mTBI to Neurodegeneration Due to Chronic Traumatic Encephalopathy (CTE) and Alzheimer's Disease (AD)

RecruitingObservational studyHealthy volunteers welcome
  • VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston
Ages 30 to 90 · All sexes · Updated Sep 1, 2026 · NCT04124029

A First-In-Human Study of LY3954068 in Participants With Early Symptomatic Alzheimer's Disease

RecruitingPhase 1
  • Massachusetts General Hospital (MGH), Charlestown · 1 mi away
Ages 50 to 85 · All sexes · Updated Aug 24, 2026 · NCT06297590

Use of a Mobile Brain-Body Imaging Approach to Evaluate the Effects of Rhythmic Auditory Stimulation on Gait and Brain Function in Alzheimer's Disease

RecruitingHealthy volunteers welcome
  • Boston University Neuromotor Recovery Laboratory, Boston
Ages 50 to 90 · All sexes · Updated Aug 13, 2026 · NCT07659964

Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant

RecruitingPhase 3
  • Massachusetts General Hospital, Boston
  • Brigham and Women's Hospital, Boston
  • Boston University (BU) School of Medicine, Boston
Ages 18 to 75 · All sexes · Updated Aug 4, 2026 · NCT06563895

Individual Closed-Loop Neuromodulation Therapy for Alzheimer's Disease

RecruitingHealthy volunteers welcome
  • Massachusetts General Hospital, Charlestown · 1 mi away
Ages 50 to 80 · All sexes · Updated Jul 14, 2026 · NCT05904132

Gamma Light and Sound Stimulation to Prevent Dementia in Cognitively Normal People at Risk for Alzheimer's Disease

RecruitingHealthy volunteers welcome
  • Massachusetts General Hospital, Boston
Ages 55 to 90 · All sexes · Updated Jun 18, 2026 · NCT05776641

Biomarker-based Trial of NPC-1 for Alzheimer's Pathology

RecruitingPhase 2
  • Massachusetts General Hospital, Boston
Ages 55 and older · All sexes · Updated Jun 8, 2026 · NCT07236190

Trial-Ready Cohort-Down Syndrome (TRC-DS)

RecruitingObservational study
  • Massachusetts General Hospital, Co-Enrolling through ABC-DS Only, Boston
Ages 25 to 55 · All sexes · Updated May 18, 2026 · NCT04165109

Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease

RecruitingEarly phase 1Healthy volunteers welcome
  • Massachusetts General Hospital, Boston
Ages 40 to 99 · All sexes · Updated May 6, 2026 · NCT06538311

Cognitive Neurology Unit Clinical Registry

RecruitingObservational study
  • Beth Israel Deaconess Medical Center, Boston
Ages 50 to 95 · All sexes · Updated Apr 13, 2026 · NCT05925621

Digital Accessible Remote Olfactory Mediated Health Assessments for Preclinical AD

RecruitingObservational studyHealthy volunteers welcome
  • Massachusetts General Hospital, Boston
Ages 18 to 100 · All sexes · Updated Mar 6, 2026 · NCT05881239

Assessment of Foralumab Safety and Modulation of Microglial Activation in Alzheimer's Disease

RecruitingPhase 2
  • Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Boston
Ages 60 to 85 · All sexes · Updated Feb 12, 2026 · NCT06489548

PET Brain Imaging in Multiple Sclerosis, Alzheimer's Disease, and Other Neurological and Neuropsychiatric Diseases

RecruitingPhase 1/2Healthy volunteers welcome
  • Brigham MS Center, 60 Fenwood Road, Boston
Ages 18 to 85 · All sexes · Updated Jan 28, 2026 · NCT02649985

Non-invasive Brain Stimulation for Cognitive and Motor Dysfunction in Dementia

Recruiting
  • Hinda and Arthur Marcus Institute for Aging Research, Boston
Ages 55 and older · All sexes · Updated Jan 12, 2026 · NCT05661084

Trial to Reduce Antimicrobial Use in Nursing Home Residents With Alzheimer's Disease and Other Dementias 2.0

Recruiting
  • Hebrew SeniorLife, Boston
Ages 60 to 106 · All sexes · Updated Jan 6, 2026 · NCT05950607

Assess Fibrin in Brains With AD/ADRD

RecruitingPhase 1/2Healthy volunteers welcome
  • Massachusetts General Hospital, Boston
Ages 55 to 90 · All sexes · Updated Oct 30, 2025 · NCT05336695

Mindfulness for Cognition in Early-stage Alzheimer's Disease

RecruitingHealthy volunteers welcome
  • VA Boston Healthcare System - Jamaica Plain Campus, Boston
Ages 50 to 100 · All sexes · Updated Jan 27, 2025 · NCT06792877

Triage Survey for Neurology Research Eligibility

RecruitingObservational studyHealthy volunteers welcome
  • Copley Clinical, Boston
Ages 18 and older · All sexes · Updated Oct 27, 2023 · NCT06104852

Gamma-Music Based Intervention for Mild Alzheimer's Disease

RecruitingHealthy volunteers welcome
  • Northeastern University, Boston
Ages 50 to 95 · All sexes · Updated Oct 6, 2023 · NCT05984524

About Alzheimer's Disease

Alzheimer's disease is a brain disorder that slowly destroys memory and thinking skills. It's the most common cause of dementia among older adults.

More about Alzheimer's Disease on MedlinePlus

Alzheimer's Disease trials in other cities

Other studies in Boston

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.