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Prostate Cancer clinical trials in Philadelphia, PA

44 studies for Prostate Cancer are looking for participants at sites in and around Philadelphia (within about 30 miles). Open a study to see who can join and how to contact the study team.

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The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2

Abramson Cancer Center of the University of Pennsylvania, Philadelphia

Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750

Testing the Addition of Docetaxel (Chemotherapy) to the Usual Treatment (Hormonal Therapy and Apalutamide) for Metastatic Prostate Cancer, ASPIRE Trial

RecruitingPhase 3

Thomas Jefferson University Hospital, Philadelphia
Jefferson Torresdale Hospital, Philadelphia
Asplundh Cancer Pavilion, Willow Grove · 13 mi away

Ages 18 and older · Men · Updated Oct 2, 2026 · NCT06931340

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome

Reading Hospital McGlinn Cancer Institute at Phoenixville, Phoenixville · 22 mi away

Ages 40 to 75 · All sexes · Updated Oct 2, 2026 · NCT05334069

A Study of JNJ-87189401 Combined With JNJ-78278343 for Advanced Prostate Cancer

RecruitingPhase 1

Sidney Kimmel Cancer Center - Jefferson Health, Philadelphia

Ages 18 and older · Men · Updated Sep 28, 2026 · NCT06095089

DESTINY-PANTUMOUR04

RecruitingObservational study

Research Site, Philadelphia

Ages 18 to 130 · All sexes · Updated Sep 25, 2026 · NCT07124000

A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)

RecruitingPhase 3

Fox Chase Cancer Center ( Site 0076), Philadelphia
MidLantic urology ( Site 0022), Bala-Cynwyd · 5 mi away

Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06136650

This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.

RecruitingPhase 3

MidLantic urology, Bala-Cynwyd · 5 mi away

Ages 18 and older · Men · Updated Sep 24, 2026 · NCT07028853

Open-label Study Comparing AAA817 Versus Standard of Care in the Treatment of Previously Treated PSMA-positive mCRPC Adults Who Have Disease Progressed on or After [177Lu]Lu-PSMA Targeted Therapy

RecruitingPhase 2/3

Fox Chase Cancer Center, Philadelphia

Ages 18 to 100 · Men · Updated Sep 22, 2026 · NCT06780670

Carboplatin or Olaparib for BRcA Deficient Prostate Cancer

RecruitingPhase 2

Philadelphia MultiService Center, Philadelphia, PA, Philadelphia

Ages 18 and older · Men · Updated Sep 17, 2026 · NCT04038502

A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)

RecruitingPhase 3

Perelman Center for Advanced Medicine ( Site 0067), Philadelphia
Abramson Cancer Center - Penn Medicine ( Site 0079), Philadelphia

Ages 18 and older · Men · Updated Sep 17, 2026 · NCT06925737

First-Time-in-Human Study of GSK5471713 in Adults With mCRPC

RecruitingPhase 1/2

GSK Investigational Site, Philadelphia

Ages 18 and older · Men · Updated Sep 16, 2026 · NCT07332455

Trial of Xaluritamig in Adults With Metastatic Castration-resistant Prostate Cancer

RecruitingPhase 1

Thomas Jefferson University, Philadelphia

Ages 18 and older · Men · Updated Sep 15, 2026 · NCT07493512

Sacral Neuromodulation for Male Overactive Bladder (MOAB)

Recruiting

MidLantic Urology, Bala-Cynwyd · 5 mi away

Ages 18 and older · Men · Updated Sep 14, 2026 · NCT06511141

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

RecruitingPhase 3

Christiana Care Health System-Concord Health Center, Chadds Ford · 23 mi away
Christiana Care Health System-Wilmington Hospital, Wilmington · 25 mi away

Ages 18 and older · Men · Updated Sep 10, 2026 · NCT05946213

A Study of Tarlatamab for People With Prostate Cancer

RecruitingPhase 2

Thomas Jefferson University Hospital, Philadelphia

Ages 18 and older · Men · Updated Aug 31, 2026 · NCT07111507

A Study of Talazoparib With or Without Enzalutamide in People With Prostate Cancer Who Have Previously Received Abiraterone Acetate or Darolutamide

RecruitingPhase 2

Abramson Cancer Center of the University of Pennsylvania, Hospital of the University of Pennsylvania, Philadelphia

Ages 18 and older · Men · Updated Aug 21, 2026 · NCT06844383

Study of AMG 509 in Participants With Metastatic Castration-Resistant Prostate Cancer

RecruitingPhase 1

Thomas Jefferson University, Philadelphia

Ages 18 and older · Men · Updated Aug 21, 2026 · NCT04221542

Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging

RecruitingPhase 3

Penn Presbyterian Medical Center, Philadelphia
University of Pennsylvania/Abramson Cancer Center, Philadelphia
Thomas Jefferson University Hospital, Philadelphia

Ages 18 and older · Men · Updated Aug 19, 2026 · NCT04423211

FOG-001 in Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2

University of Pennsylvania, Perelman School of Medicine, Philadelphia

Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT05919264

Study of JANX007 in Subjects With Metastatic Castration-Resistant Prostate Cancer (ENGAGER-PSMA-01)

RecruitingPhase 1

Thomas Jefferson University Honickman Center, Philadelphia

Ages 18 to 100 · Men · Updated Aug 13, 2026 · NCT05519449

Evaluation of Neoadjuvant Xaluritamig in Localized Prostate Cancer

RecruitingPhase 1

Thomas Jefferson University, Philadelphia

Ages 18 and older · Men · Updated Jul 31, 2026 · NCT06613100

Study of Orally Administered MOMA-313 in Participants With Advanced or Metastatic Solid Tumors

RecruitingPhase 1

Investigative Site #109, Philadelphia

Ages 18 and older · All sexes · Updated Jul 23, 2026 · NCT06545942

PSMA PET Combined With MRI for the Detection of PCa

RecruitingPhase 3Healthy volunteers welcome

MidLantic Urology, Philadelphia

Ages 18 and older · Men · Updated Jul 23, 2026 · NCT07052214

Docetaxel to Androgen Receptor Pathway Inhibitors in Patients With Metastatic Castration Sensitive Prostate Cancer and Suboptimal PSA Response

RecruitingPhase 3

Philadelphia Veterans Administration Medical Center, Philadelphia
Christiana Care Health System-Concord Health Center, Chadds Ford · 23 mi away
Christiana Care Health System-Wilmington Hospital, Wilmington · 25 mi away

Ages 18 and older · Men · Updated Jul 14, 2026 · NCT06592924

Study of ORIC-944 in Patients With Metastatic Prostate Cancer

RecruitingPhase 1

MidLantic Urology, Bala-Cynwyd · 5 mi away

Ages 18 and older · Men · Updated Jul 9, 2026 · NCT05413421

Study Evaluating the Safety, Tolerability, and Efficacy of Xaluritamig in Combination With Androgen Receptor Pathway Inhibitors in Participants With Metastatic Hormone-sensitive Prostate Cancer

RecruitingPhase 1

Thomas Jefferson University, Philadelphia

Ages 18 and older · Men · Updated Jul 2, 2026 · NCT07140900

A Study of Tinengotinib (TT-00420) in Combination With Standard Treatments in People With Prostate Cancer

RecruitingPhase 1/2

Thomas Jefferson University Hospital, Philadelphia

Ages 18 and older · Men · Updated Jun 25, 2026 · NCT06457919

Abiraterone, Enzalutamide, or Apalutamide in Castrate-sensitive Prostate Cancer.

RecruitingPhase 2

Corporal Michael J. Crescenz VA Medical Center, Philadelphia

Ages 18 and older · Men · Updated Jun 15, 2026 · NCT05422911

TERPS Trial for de Novo Oligometastic Prostate Cancer

RecruitingPhase 2

Sidney Kimmel Cancer Center at Jefferson Health, Philadelphia

Ages 18 and older · Men · Updated Jun 3, 2026 · NCT05223803

International Registry for Men With Advanced Prostate Cancer (IRONMAN)

RecruitingObservational study

Fox Chase Cancer Center - Temple Health, Philadelphia

Ages 21 and older · Men · Updated May 22, 2026 · NCT03151629

Prostate Cancer Screening for People at Genetic Risk for Aggressive Disease, PATROL Study

RecruitingObservational studyHealthy volunteers welcome

University of Pennsylvania/Abramson Cancer Center, Philadelphia

Ages 40 and older · Men · Updated May 15, 2026 · NCT04472338

Extending Prostate Genetic Awareness, Navigation, and Delivery: The EXPAND Network

RecruitingObservational studyHealthy volunteers welcome

Sidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia

Ages 18 and older · Men · Updated May 15, 2026 · NCT05627219

Peer Navigation for the Support of Metastatic Prostate Cancer Patients Undergoing Genetic Evaluation

Recruiting

Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University, Philadelphia

Ages 18 and older · Men · Updated Apr 14, 2026 · NCT05487846

Veterans Affairs Seamless Phase II/III Randomized Trial of STAndard Systemic theRapy With or Without PET-directed Local Therapy for Oligometastatic pRosTate Cancer

RecruitingPhase 2/3

Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, Philadelphia

Ages 18 and older · Men · Updated Apr 8, 2026 · NCT04787744

A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies

RecruitingPhase 1/2

Thomas Jefferson University, Sidney Kimmel Comprehensive Cancer Center, Philadelphia

Ages 18 and older · All sexes · Updated Mar 27, 2026 · NCT06395519

Study of AZD0754 in Participants With Metastatic Prostate Cancer

RecruitingPhase 1/2

Research Site, Philadelphia

Ages 18 to 130 · Men · Updated Feb 23, 2026 · NCT06267729

A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

RecruitingPhase 1

Thomas Jefferson University, Sidney Kimmel Cancer Center, Philadelphia
Fox Chase Cancer Center, Philadelphia

Ages 18 and older · All sexes · Updated Feb 13, 2026 · NCT06778863

Hypofractionated WPPT With HDR Boost

RecruitingPhase 2

University of Pennsylvania, Philadelphia

Ages 18 and older · All sexes · Updated Feb 5, 2026 · NCT06591819

A Safety and Dose-finding Study of PRL-02 Depot in Men With Advanced Prostate Cancer

RecruitingPhase 1

MidLantic Urology, Bala-Cynwyd · 5 mi away

Ages 18 and older · Men · Updated Feb 4, 2026 · NCT04729114

Testing Whether the Addition of Carboplatin Chemotherapy to Cabazitaxel Chemotherapy Will Improve Outcomes Compared to Cabazitaxel Alone in People With Castrate-Resistant Prostate Cancer That Has Spread Beyond the Prostate to Other Parts of the Body

RecruitingPhase 3

Christiana Care Health System-Concord Health Center, Chadds Ford · 23 mi away
Christiana Care Health System-Wilmington Hospital, Wilmington · 25 mi away

Ages 18 and older · Men · Updated Jan 22, 2026 · NCT06470243

Effect on Body Movement and Mental Skills in Patients Who Received Gadolinium-based Contrast Media for Magnetic Resonance Examination Multiple Times Within 5 Years

RecruitingPhase 4

Albert Einstein Healthcare Network, Philadelphia

Ages 18 to 64 · All sexes · Updated Jan 22, 2026 · NCT04373564

Prostate Tissue BioBank

RecruitingObservational study

University of Pennsylvania, Philadelphia

Ages 18 and older · Men · Updated Nov 5, 2025 · NCT06659614

Adaptive Radiation Therapy for Men With Intermediate- or High-Risk Prostate Cancer

Recruiting

Fox Chase Cancer Center, Philadelphia

Ages 18 and older · Men · Updated Oct 29, 2025 · NCT07219303

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study

Massive Bio SYNERGY-AI site, Philadelphia

All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

About Prostate Cancer

Prostate cancer is one of the most common types of cancer among American men. The risk goes up as men age. Learn about symptoms, tests, and treatment.

More about Prostate Cancer on MedlinePlus

Prostate Cancer trials in other cities

Other studies in Philadelphia

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.