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Obesity clinical trials in Durham, NC

20 studies for Obesity are looking for participants at sites in and around Durham (within about 30 miles). Open a study to see who can join and how to contact the study team.

AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight

RecruitingPhase 3
  • UNC Eastowne Medical Office, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT07339423

A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)

RecruitingPhase 3
  • Duke Children's Primary Care, Durham
  • UNC Children's Hospital, Chapel Hill · 10 mi away
Ages 6 to 17 · All sexes · Updated Sep 24, 2026 · NCT06672549

FAMily-centered WEight Loss for Black Adults (FAM WEL B-ing)

Recruiting
  • University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Ages 18 to 75 · All sexes · Updated Sep 23, 2026 · NCT06724406

Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity

RecruitingPhase 3
  • Velocity Clinical Research - Durham, Durham
Ages 45 to 99 · All sexes · Updated Sep 22, 2026 · NCT07037433

A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin

RecruitingPhase 3
  • University of North Carolina Medical Center, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07392190

A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Type 2 Diabetes

RecruitingPhase 3
  • AURORA-2 Clinical Site, Durham
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT07743450

Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

RecruitingPhase 3
  • Duke University Health System, Durham
Ages 18 to 99 · All sexes · Updated Sep 16, 2026 · NCT07037459

Tirzepatide in Obesity-Driven Endometrial Cancer

RecruitingEarly phase 1
  • Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Ages 18 and older · Women · Updated Sep 11, 2026 · NCT07065552

A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)

RecruitingPhase 3Healthy volunteers welcome
  • ACCOMPLISH-2 Research Site, Durham
Ages 18 to 79 · All sexes · Updated Sep 11, 2026 · NCT07654374

Using Tailored mHealth Strategies to Promote Weight Management Among Adolescent and Young Adult Cancer Survivors

Recruiting
  • University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Ages 18 to 39 · All sexes · Updated Aug 24, 2026 · NCT06848491

A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity

RecruitingPhase 3
  • Duke University, Durham
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07567001

Efficacy and Safety of Aleniglipron in Participants With Obesity or Overweight With a Weight-Related Comorbidity (ACCOMPLISH-1)

RecruitingPhase 3
  • ACCOMPLISH-1 Research Site, Durham
Ages 18 to 79 · All sexes · Updated Aug 10, 2026 · NCT07654361

Mechanistic Study of Inspiratory Training in Childhood Asthma (MICA)

Recruiting
  • Duke Health Center Creekstone, Durham
  • Duke Healthy Lifestyles Clinic, Durham
Ages 6 to 17 · All sexes · Updated Aug 5, 2026 · NCT05945355

A Study to See How Safe and Effective Alirocumab is When Given Weekly to Adult Participants Who Have Hypercholesterolemia

RecruitingPhase 2
  • Velocity Clinical Research - Durham, Durham
Ages 18 to 80 · All sexes · Updated Jul 22, 2026 · NCT07477704

Optimizing Telehealth-delivery of a Weight Loss Intervention in Older Adults

Recruiting
  • UNC Center for Aging and Health, Chapel Hill · 10 mi away
Ages 65 to 85 · All sexes · Updated Feb 6, 2026 · NCT06044571

ONC201 and Atezolizumab in Obesity-Driven Endometrial Cancer

RecruitingPhase 1
  • Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Ages 18 and older · Women · Updated Jan 29, 2026 · NCT05542407

Interscalene vs Phrenic-sparing Blocks in Obesity and Effect of Maximum Inspiratory Pressure

Recruiting
  • University of North Carolina Hospitals, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Jan 28, 2026 · NCT07216820

Inspiratory Pulmonary Rehabilitation for Children With Obesity and Asthma

Recruiting
  • Duke Healthy Lifestyles Clinic, Durham
Ages 8 to 17 · All sexes · Updated Aug 22, 2025 · NCT05608668

Supplementing L-citrulline to Overweight Late Asthma oNset Phenotypes

RecruitingPhase 2Healthy volunteers welcome
  • Duke University (Asthma, Allergy and Airway Center), Durham
Ages 18 to 65 · All sexes · Updated Jun 10, 2025 · NCT03885245

Investigating Whether Acute Elevation of Fatty Acid Levels Alters Cerebral Glucose Transport and Metabolism

RecruitingPhase 1/2Healthy volunteers welcome
  • Biomedical Research Imaging Center Marsico Hall (UNC), Chapel Hill · 10 mi away
  • Clinical and Translational Research Center (CTRC) Burnett-Womack Building (UNC), Chapel Hill · 10 mi away
Ages 18 to 45 · All sexes · Updated Mar 30, 2025 · NCT04328337

About Obesity

Read about the causes of obesity and find out what you can do to decrease your risk of its associated health issues.

More about Obesity on MedlinePlus

Obesity trials in other cities

Other studies in Durham

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.