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Obesity clinical trials in Durham, NC

17 studies for Obesity are looking for participants at sites in and around Durham (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Efficacy, Safety, and Pharmacokinetics of Tirzepatide (LY3298176) Once Weekly Versus Placebo in Pediatric Participants 6 to Less Than 12 Years of Age Who Have Obesity (ADVANCE-SURMOUNT-KIDS)

RecruitingPhase 3
  • Duke Children's Primary Care, Durham
  • UNC Children's Hospital, Chapel Hill · 10 mi away
Ages 6 to 11 · All sexes · Updated Nov 4, 2026 · NCT07817875

A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin

RecruitingPhase 3
  • University of North Carolina Medical Center, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07392190

A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)

RecruitingPhase 3
  • Duke Children's Primary Care, Durham
  • UNC Children's Hospital, Chapel Hill · 10 mi away
Ages 6 to 17 · All sexes · Updated Nov 4, 2026 · NCT06672549

Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

RecruitingPhase 3
  • Duke University Health System, Durham
Ages 18 to 99 · All sexes · Updated Oct 29, 2026 · NCT07037459

A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)

RecruitingPhase 3Healthy volunteers welcome
  • ACCOMPLISH-2 Research Site, Durham
Ages 18 to 79 · All sexes · Updated Oct 20, 2026 · NCT07654374

Tirzepatide in Obesity-Driven Endometrial Cancer

RecruitingEarly phase 1
  • Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Ages 18 and older · Women · Updated Oct 2, 2026 · NCT07065552

FAMily-centered WEight Loss for Black Adults (FAM WEL B-ing)

Recruiting
  • University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Ages 18 to 75 · All sexes · Updated Sep 29, 2026 · NCT06724406

AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight

RecruitingPhase 3
  • UNC Eastowne Medical Office, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT07339423

A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Type 2 Diabetes

RecruitingPhase 3
  • AURORA-2 Clinical Site, Durham
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT07743450

Using Tailored mHealth Strategies to Promote Weight Management Among Adolescent and Young Adult Cancer Survivors

Recruiting
  • University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Ages 18 to 39 · All sexes · Updated Aug 24, 2026 · NCT06848491

A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity

RecruitingPhase 3
  • Duke University, Durham
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07567001

Efficacy and Safety of Aleniglipron in Participants With Obesity or Overweight With a Weight-Related Comorbidity (ACCOMPLISH-1)

RecruitingPhase 3
  • ACCOMPLISH-1 Research Site, Durham
Ages 18 to 79 · All sexes · Updated Aug 10, 2026 · NCT07654361

Mechanistic Study of Inspiratory Training in Childhood Asthma (MICA)

Recruiting
  • Duke Health Center Creekstone, Durham
  • Duke Healthy Lifestyles Clinic, Durham
Ages 6 to 17 · All sexes · Updated Aug 5, 2026 · NCT05945355

Optimizing Telehealth-delivery of a Weight Loss Intervention in Older Adults

Recruiting
  • UNC Center for Aging and Health, Chapel Hill · 10 mi away
Ages 65 to 85 · All sexes · Updated Feb 6, 2026 · NCT06044571

ONC201 and Atezolizumab in Obesity-Driven Endometrial Cancer

RecruitingPhase 1
  • Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Ages 18 and older · Women · Updated Jan 29, 2026 · NCT05542407

Interscalene vs Phrenic-sparing Blocks in Obesity and Effect of Maximum Inspiratory Pressure

Recruiting
  • University of North Carolina Hospitals, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Jan 28, 2026 · NCT07216820

Supplementing L-citrulline to Overweight Late Asthma oNset Phenotypes

RecruitingPhase 2Healthy volunteers welcome
  • Duke University (Asthma, Allergy and Airway Center), Durham
Ages 18 to 65 · All sexes · Updated Jun 10, 2025 · NCT03885245

About Obesity

Read about the causes of obesity and find out what you can do to decrease your risk of its associated health issues.

More about Obesity on MedlinePlus

Obesity trials in other cities

Other studies in Durham

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.