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Obesity clinical trials in Boston, MA

28 studies for Obesity are looking for participants at sites in and around Boston (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)

RecruitingPhase 3
  • Boston Children's Hospital, Boston
Ages 6 to 17 · All sexes · Updated Sep 24, 2026 · NCT06672549

A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin

RecruitingPhase 3
  • Brigham and Women's Hospital Diabetes Program, Boston
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07392190

Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity

RecruitingPhase 3
  • Brigham and Womens Hospital, Boston
Ages 45 to 99 · All sexes · Updated Sep 22, 2026 · NCT07037433

A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes

RecruitingPhase 3
  • Boston Medical Center, Boston
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT07351045

The Effects of Lumateperone on Obesity and Physiologic Aging and Their Association With Antidepressant Response in Bipolar Depression

RecruitingPhase 4
  • Massachusetts General Hospital, Boston
Ages 18 to 65 · All sexes · Updated Sep 11, 2026 · NCT07699445

Efficacy and Safety of Ribupatide Administered Once Weekly in Participants Living With Obesity or Overweight and Diabetes

RecruitingPhase 3
  • Kailera Clinical Site, Boston
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT07284901

Concurrent Laparoscopic Hysterectomy and Weight Loss Surgery in Obese Patients With Endometrial Carcinoma or Endometrial Intraepithelial Neoplasia

Recruiting
  • Brigham and Women's Hospital, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · Women · Updated Aug 31, 2026 · NCT04839614

Redefining Evaluation of Adiposity and Leanness: Broadening Objective Diagnostics for Obesity

RecruitingObservational study
  • Exponent Boston, Boston
Ages 18 and older · All sexes · Updated Aug 20, 2026 · NCT07776678

The Osteoarthritis Prevention Study

RecruitingHealthy volunteers welcome
  • Brigham and Women's Hospital, Boston
Ages 50 and older · Women · Updated Jul 23, 2026 · NCT05946044

Family-Based Weight Wellness Treatment Through Food is Medicine and Group Medical Visits in Pediatric and Adult Primary Care

Recruiting
  • Tufts Medical Center, Boston
  • Tufts University, Boston
Ages 12 to 17 · All sexes · Updated Jul 21, 2026 · NCT07717658

Facilitated Transitions From Postpartum to Primary Care Coordination for People With Chronic Conditions

Recruiting
  • Massachusetts General Hospital, Boston
Ages 18 and older · Women · Updated Jul 13, 2026 · NCT06557005

Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial

Recruiting
  • Brigham and Women's Hospital, Boston
Ages 18 and older · All sexes · Updated Jun 25, 2026 · NCT06138821

Trans-nasal Endoscopy for Bariatric Patients

Recruiting
  • Brigham and Women's Hospital, Boston
Ages 18 to 90 · All sexes · Updated Jun 25, 2026 · NCT06200961

BILe Acid-gut Microbiome Axis MODification Through Diet Education for Colorectal Cancer Prevention

Recruiting
  • Massachusetts General Hospital Cancer Center, Boston
Ages 18 to 80 · All sexes · Updated Jun 23, 2026 · NCT07162337

Effect of Tirzepatide and Bimagrumab on Body Composition, Insulin Sensitivity, and Bone in Adults With Obesity

RecruitingPhase 2
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated Mar 27, 2026 · NCT05933499

Endoscopic Ultrasound Shear Wave Elastography in Patients With Non-alcoholic Fatty Liver Disease

RecruitingObservational study
  • Brigham and Women's Hospital, Boston
  • Brigham and Women's Faulkner Hospital, Boston
Ages 18 and older · All sexes · Updated Mar 2, 2026 · NCT05728697

Efficacy and Safety of Endoscopic Antral Myotomy as a Novel Weight Loss Procedure

RecruitingObservational study
  • Brigham and Women's Hospital, Boston
Ages 18 to 70 · All sexes · Updated Mar 2, 2026 · NCT05711758

Pathways, Risk Factors, and mOleculeS to Prevent Early-onset Colorectal Tumors

RecruitingPhase 1
  • Massachusetts General Hospital Cancer Center, Boston
Ages 18 to 50 · All sexes · Updated Feb 27, 2026 · NCT07095517

Effects of Whole vs. Nonfat Milk Consumption on Body Composition in Children

RecruitingHealthy volunteers welcome
  • New Balance Foundation Obesity Prevention Center, Boston
Ages 9 to 12 · All sexes · Updated Jan 8, 2026 · NCT05464186

Body Composition and Exercise to Prevent Muscle Loss With GLP1 Agonist Treatment

Recruiting
  • Diabetes Research Center, Boston
Ages 18 to 99 · All sexes · Updated Dec 30, 2025 · NCT07226947

Medically Intensive Nutrition Therapy Program for Obesity and Diabetes in a Low-income Population

RecruitingObservational study
  • Massachusetts General Hospital, Boston
Ages 18 to 65 · All sexes · Updated Dec 24, 2025 · NCT05799222

A Study of RM-718 in Healthy Subjects and Patients With MC4R Pathway Impairment

RecruitingPhase 1/2Healthy volunteers welcome
  • Boston Children's Hospital (Part C only), Boston
  • Brigham and Women's Hospital (Part C and Part D), Boston
Ages 12 to 65 · All sexes · Updated Dec 22, 2025 · NCT06239116

Role of Caveolin 1 (CAV-1) Deficiency in Response to Glucagon-like Peptide 1 (GLP-1) Receptor Agonist Treatment

RecruitingObservational study
  • Brigham and Women's Hospital, Boston
Ages 18 and older · All sexes · Updated Dec 10, 2025 · NCT06069622

Validation of a Novel Cerebellar-striatal Satiety Circuit in Humans

RecruitingHealthy volunteers welcome
  • Brigham and Women's Hospital, Boston
Ages 18 to 65 · All sexes · Updated Dec 5, 2025 · NCT06105164

Building Connections

Recruiting
  • Disparities Research Unit, Massachusetts General Hospital, Boston
Ages 18 to 75 · All sexes · Updated Nov 18, 2025 · NCT07091032

The Physiology of Human Brown Adipose Tissue

RecruitingObservational studyHealthy volunteers welcome
  • Beth Israel Deaconess Medical Center, Boston
Ages 18 to 75 · All sexes · Updated Oct 31, 2025 · NCT04352244

Exercise, Brain Activity, and Weight Maintenance

RecruitingHealthy volunteers welcome
  • Joslin Diabetes Center, Boston
Ages 18 to 70 · All sexes · Updated Sep 4, 2025 · NCT06511310

RESET System Pivotal Trial (Rev F)

Recruiting
  • Brigham and Women's Hospital, Boston
Ages 22 to 65 · All sexes · Updated Jul 18, 2024 · NCT04101669

About Obesity

Read about the causes of obesity and find out what you can do to decrease your risk of its associated health issues.

More about Obesity on MedlinePlus

Obesity trials in other cities

Other studies in Boston

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.