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Major Depressive Disorder clinical trials in Miami, FL

18 studies for Major Depressive Disorder are looking for participants at sites in and around Miami (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder

RecruitingPhase 3
  • Miami Jewish health, Miami
  • Quantix Research - Miami - Southwest 72nd Street, Miami
  • Diverse Clinical Research, Miami
Ages 18 to 75 · All sexes · Updated Oct 1, 2026 · NCT07775300

A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder

RecruitingPhase 3
  • Pharmax Research Clinic Inc, Miami
  • Nuovida Research Center, Miami
Ages 18 to 74 · All sexes · Updated Oct 1, 2026 · NCT07573176

Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms

RecruitingPhase 3
  • Pharmax Research Clinic Inc, Miami
  • Miami Dade Medical Research Institute, Miami
  • Nuovida Research Center, Miami
Ages 18 to 74 · All sexes · Updated Sep 25, 2026 · NCT06559306

A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 2
  • Central Miami Medical Institute Llc., Miami
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07621237

Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder

RecruitingPhase 3
  • Premier Clinical Research Institute, Miami
  • Miami Jewish Health System, Miami
Ages 18 to 65 · All sexes · Updated Sep 25, 2026 · NCT05850689

Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder

RecruitingPhase 3
  • Vanda Investigational Site, Miami
Ages 18 to 65 · All sexes · Updated Sep 24, 2026 · NCT06830044

A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression

RecruitingPhase 2
  • Draig Clinical Site, Miami
Ages 18 to 75 · All sexes · Updated Aug 26, 2026 · NCT07300969

NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, Miami
Ages 18 and older · All sexes · Updated Aug 10, 2026 · NCT06963021

A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder

RecruitingPhase 3
  • PharmaSouth Research, Miami
Ages 18 to 74 · All sexes · Updated Aug 3, 2026 · NCT06775379

Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder

RecruitingPhase 2
  • Premier Clinical Research Institute, Inc., Miami
  • Miami Dade Medical Research Institute, Miami
Ages 18 to 64 · All sexes · Updated Aug 3, 2026 · NCT06547489

A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder

RecruitingPhase 2
  • Premier Clinical Research Institute Inc, Miami
Ages 18 to 64 · All sexes · Updated Jul 27, 2026 · NCT07115329

Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, Miami
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT06966401

Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol

RecruitingPhase 3
  • Clinical Research Site, Miami
  • Clinical Research Site, Miami
Ages 18 to 65 · All sexes · Updated Jul 24, 2026 · NCT07484217

A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder

RecruitingPhase 2
  • GMI Florida - Central Miami Medical Institute /ID# 278218, Miami
Ages 18 to 65 · All sexes · Updated Jun 15, 2026 · NCT07276997

A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)

RecruitingPhase 2
  • Bioresearch Partner, Miami
Ages 18 to 65 · All sexes · Updated May 11, 2026 · NCT06524830

Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder (AMPLIFY)

RecruitingPhase 2
  • Autobahn Site #111, Miami
Ages 18 to 65 · All sexes · Updated Jan 20, 2026 · NCT06633016

A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms

RecruitingPhase 4
  • Clinical Research Site, Miami
Ages 18 to 65 · All sexes · Updated Jan 23, 2025 · NCT06223880

Major Depressive Disorder trials in other cities

Other studies in Miami

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.