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Amyotrophic Lateral Sclerosis clinical trials in Philadelphia, PA

14 studies for Amyotrophic Lateral Sclerosis are looking for participants at sites in and around Philadelphia (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Developing New Ways to Detect Respiratory Impairment Early in ALS

RecruitingObservational studyHealthy volunteers welcome
  • Thomas Jefferson University - Center City, Philadelphia
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07844590

Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS

RecruitingPhase 3
  • Neuroscience Department at LKSM at Temple University, Philadelphia
Ages 18 to 80 · All sexes · Updated Sep 22, 2026 · NCT07322003

RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses

RecruitingPhase 2
  • University of Pennsylvania, Philadelphia
Ages 18 to 80 · All sexes · Updated Sep 15, 2026 · NCT07002034

Study is to Assess the Safety and Tolerability of VTx-002 in Participants With ALS

RecruitingPhase 1/2
  • University of Pennsylvania, Philadelphia
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT07287397

Biofluid Research on Age-Related or Inherited Neurodegeneration

RecruitingObservational studyHealthy volunteers welcome
  • University of Pennsylvania, Philadelphia
Ages 18 and older · All sexes · Updated Sep 1, 2026 · NCT07798700

ASSESS ALL ALS Study

RecruitingObservational studyHealthy volunteers welcome
  • University of Pennsylvania, Philadelphia
  • Temple University, Philadelphia
Ages 18 and older · All sexes · Updated Aug 24, 2026 · NCT06578195

PREVENT ALL ALS Study

RecruitingObservational studyHealthy volunteers welcome
  • Temple University, Philadelphia
Ages 18 and older · All sexes · Updated Aug 24, 2026 · NCT06581861

Study of COYA 302 for the Treatment of ALS

RecruitingPhase 2/3
  • Thomas Jefferson University-Weinberg ALS Center, Philadelphia
  • Temple Neurology, Philadelphia
Ages 18 to 80 · All sexes · Updated Aug 6, 2026 · NCT07161999

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

RecruitingObservational studyHealthy volunteers welcome
  • University of Pennsylvania, Philadelphia
Ages 18 and older · All sexes · Updated Jul 30, 2026 · NCT04363684

A Clinical Trial of Early Ventilation in Amyotrophic Lateral Sclerosis (EVENT ALS)

RecruitingPhase 2
  • Penn Comprehensive ALS Center at Pennsylvania Hospital, Philadelphia
Ages 18 and older · All sexes · Updated Jun 26, 2026 · NCT07071935

ALS/MND Natural History Study Data Repository

RecruitingObservational study
  • Thomas Jefferson University, Philadelphia
  • Temple University Lewis Katz School of Medicine, Philadelphia
Ages 18 to 90 · All sexes · Updated May 20, 2026 · NCT05966038

AMX0114 in Adult Participants With Amyotrophic Lateral Sclerosis

RecruitingPhase 1
  • Temple University of the Commonwealth System of Higher Education, Philadelphia
Ages 18 and older · All sexes · Updated Apr 14, 2026 · NCT06665165

UPenn Observational Research Repository on Neurodegenerative Disease

RecruitingObservational studyHealthy volunteers welcome
  • University of Pennsylvania, Philadelphia
Ages 18 and older · All sexes · Updated Jan 22, 2026 · NCT04715399

About Amyotrophic Lateral Sclerosis

ALS stands for Amyotrophic Lateral Sclerosis, also called Lou Gehrig's disease. ALS affects the nervous system, causing muscle problems. Find out how.

More about Amyotrophic Lateral Sclerosis on MedlinePlus

Amyotrophic Lateral Sclerosis trials in other cities

Other studies in Philadelphia

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.