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Prostate Cancer clinical trials in Houston, TX

76 studies for Prostate Cancer are looking for participants at sites in and around Houston (within about 30 miles). Open a study to see who can join and how to contact the study team.

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The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

RecruitingPhase 1
  • University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06465069

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • UT MD Anderson Cancer Center, Houston
Ages 40 to 75 · All sexes · Updated Oct 2, 2026 · NCT05334069

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 2
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06172478

A Study of JNJ-87189401 Combined With JNJ-78278343 for Advanced Prostate Cancer

RecruitingPhase 1
  • MD Anderson Cancer Center, Houston
Ages 18 and older · Men · Updated Sep 28, 2026 · NCT06095089

Pre-Surgical Tirzepatide-Assisted Weight Loss in Overweight and Obese Men With Intermediate Risk Prostate Cancer: A Pilot Feasibility Study

RecruitingEarly phase 1
  • The University of Texas M. D. Anderson Cancer Center, Houston
Ages 18 and older · Men · Updated Sep 25, 2026 · NCT06759701

Decision Support Tool to Enhance Germline Genetic Testing for Patients With Prostate Cancer

Recruiting
  • M D Anderson Cancer Center, Houston
Ages 18 and older · Men · Updated Sep 25, 2026 · NCT07377006

Study of AZD0516 as Monotherapy and in Combination in Participants With Metastatic Prostate Cancer

RecruitingPhase 1/2
  • Research Site, Houston
Ages 18 to 130 · Men · Updated Sep 25, 2026 · NCT07181161

Study of HLD-0915 (JNJ-101556143) in Patients With Metastatic Prostate Cancer

RecruitingPhase 1/2
  • MD Anderson Cancer Center, Houston
Ages 18 and older · Men · Updated Sep 25, 2026 · NCT06800313

A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)

RecruitingPhase 3
  • Texas Oncology - Gulf Coast ( Site 8002), Houston
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06136650

A Study in Patients With Metastatic Castration-Resistant Prostate Cancer

RecruitingPhase 1
  • NEXT Houston, Houston
Ages 18 and older · Men · Updated Sep 24, 2026 · NCT07719361

A Study of LY4257496 in Participants With Cancer (OMNIRAY)

RecruitingPhase 1
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07114601

A Study of Xaluritamig Plus Abiraterone Versus Investigator's Choice in Participants With Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer

RecruitingPhase 3
  • Renovatio Clinical, Houston
Ages 18 and older · Men · Updated Sep 22, 2026 · NCT07213674

A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation

RecruitingPhase 3
  • Research Site, Houston
Ages 18 and older · Men · Updated Sep 18, 2026 · NCT06952803

Phase I/II Study of PEGylated Arginine Deiminase (ADI-PEG20) With Carboplatin and Cabazitaxel in Men With Aggressive Variant Prostate Cancers (AVPC)

RecruitingPhase 1/2
  • MD Anderson Cancer Center, Houston
Ages 18 and older · Men · Updated Sep 18, 2026 · NCT06085729

High Dose Testosterone for ATM, CDK12 or CHEK2 Altered Prostate Cancers

RecruitingPhase 2
  • Michael E. DeBakey VA Medical Center, Houston, TX, Houston
Ages 18 and older · Men · Updated Sep 17, 2026 · NCT05011383

A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)

RecruitingPhase 3
  • University of Texas-MD Anderson Cancer Center ( Site 0055), Houston
Ages 18 and older · Men · Updated Sep 17, 2026 · NCT06925737

Trial of Xaluritamig in Adults With Metastatic Castration-resistant Prostate Cancer

RecruitingPhase 1
  • University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · Men · Updated Sep 15, 2026 · NCT07493512

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

RecruitingPhase 3
  • UT MD Anderson Cancer Center, Houston
  • MD Anderson West Houston, Houston
Ages 18 and older · Men · Updated Sep 10, 2026 · NCT05946213

Safety, Pharmacokinetics, and Preliminary Efficacy of VIR-5500 (AMX-500) in Prostate Cancer

RecruitingPhase 1
  • Investigational Site Number: 401, Houston
Ages 18 and older · Men · Updated Sep 10, 2026 · NCT05997615

A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors

RecruitingPhase 1
  • UT MD Anderson, Houston
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06440005

A Study to Learn About the Investigational Drug Rinzimetostat (ORIC-944) in Patients With mCRPC Who Were Previously Treated With Abiraterone Acetate (Himalayas-1)

RecruitingPhase 3
  • Houston Metro Urology (HMU), Houston
Ages 18 and older · Men · Updated Sep 3, 2026 · NCT07723248

Phase Ib/II Platform Study of Multiple Anti-Cancer Agents in Participants With Metastatic Prostate Cancer

RecruitingPhase 1/2
  • Research Site, Houston
Ages 18 to 99 · Men · Updated Aug 27, 2026 · NCT07590934

AZD2265 Compared With Standard of Care in PSMA-positive Metastatic Castration-resistant Prostate Cancer (VECTRA-01)

RecruitingPhase 3
  • Research Site, Houston
Ages 18 and older · Men · Updated Aug 26, 2026 · NCT07611110

A Pilot Presurgical Trial of REGN5678 (Anti-PSMA x CD28) in Patients With High-risk, Localized Prostate Cancer Followed by Radical Prostatectomy

RecruitingPhase 1/2
  • M D Anderson Cancer Center, Houston
Ages 18 and older · Men · Updated Aug 25, 2026 · NCT06085664

Study of AMG 509 in Participants With Metastatic Castration-Resistant Prostate Cancer

RecruitingPhase 1
  • University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · Men · Updated Aug 21, 2026 · NCT04221542

A Phase 1b/2a Study of Pocenbrodib as Monotherapy and in Combination With Darolutamide in Participants With mCRPC

RecruitingPhase 1/2
  • Oncology Consultants, P.A, Houston
Ages 18 and older · Men · Updated Aug 20, 2026 · NCT06785636

A Study of FG-3246 in Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC)

RecruitingPhase 2
  • Oncology Consultants, Houston
Ages 18 and older · Men · Updated Aug 17, 2026 · NCT06842498

FOG-001 in Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT05919264

Genomic Biomarker-Selected Umbrella Neoadjuvant Study for High Risk Localized Prostate Cancer

RecruitingPhase 2
  • U.T. MD Anderson Cancer Center, Houston
Ages 18 and older · Men · Updated Aug 14, 2026 · NCT04812366

Diagnostic Performance Of Non-Endorectal Coil Multiparametric Magnetic Resonance Imaging Of Prostate With Flexible AIR Coil (DoNEMAC Study)

Recruiting
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Aug 14, 2026 · NCT05043012

A Ph Ib Study of REGN5678 Plus Cemiplimab in Patients With mCRPC

RecruitingPhase 1
  • The University of Texas M. D. Anderson Cancer Center, Houston
Ages 18 and older · Men · Updated Aug 14, 2026 · NCT06826768

Study of JANX007 in Subjects With Metastatic Castration-Resistant Prostate Cancer (ENGAGER-PSMA-01)

RecruitingPhase 1
  • Houston Methodist Hospital, Houston
Ages 18 to 100 · Men · Updated Aug 13, 2026 · NCT05519449

Study of AZD9574 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Advanced Solid Malignancies

RecruitingPhase 1/2
  • Research Site, Houston
Ages 18 to 130 · All sexes · Updated Aug 12, 2026 · NCT05417594

Comprehensive Monitoring of Men With Prostate Cancer Cared for by "Active Surveillance

RecruitingObservational study
  • M D Anderson Cancer Center, Houston
Ages 18 and older · Men · Updated Aug 10, 2026 · NCT05840484

A Study of DM002 in Patients With Advanced Solid Tumors

RecruitingPhase 1/2
  • The University of Texas, MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Aug 7, 2026 · NCT06751329

IDOV-Immune for Advanced Solid Tumors

RecruitingPhase 1
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT06910657

NeoAdjuvant Theranostic Lutetium Study: The Nautilus Trial

RecruitingPhase 1/2
  • M D Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Jul 15, 2026 · NCT06066437

Docetaxel to Androgen Receptor Pathway Inhibitors in Patients With Metastatic Castration Sensitive Prostate Cancer and Suboptimal PSA Response

RecruitingPhase 3
  • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston
  • Ben Taub General Hospital, Houston
  • Houston Methodist Hospital, Houston
  • and 4 more
Ages 18 and older · Men · Updated Jul 14, 2026 · NCT06592924

Testing the Safety and Effectiveness of Radiation-based Treatment (Lutetium Lu 177 Dotatate) for Metastatic Prostate Cancer That Has Neuroendocrine Cells

RecruitingPhase 2
  • UT MD Anderson Cancer Center, Houston
Ages 18 and older · Men · Updated Jul 14, 2026 · NCT05691465

Stem Cells for Erectile Dysfunction Post RALP

RecruitingPhase 1/2
  • Houston Methodist, Houston
Ages 40 to 70 · Men · Updated Jul 10, 2026 · NCT07048314

Efforts to Increase Representation in Prostate Cancer Clinical Trials at Lyndon B. Johnson Hospital

Recruiting
  • The University of Texas M. D. Anderson Cancer Center, Houston
Ages 18 and older · Men · Updated Jun 26, 2026 · NCT07591701

Androgen Ablation Therapy With or Without Niraparib After Radiation Therapy for the Treatment of High-Risk Localized or Locally Advanced Prostate Cancer

RecruitingPhase 2
  • M D Anderson Cancer Center, Houston
Ages 18 and older · Men · Updated Jun 23, 2026 · NCT04947254

Abiraterone, Enzalutamide, or Apalutamide in Castrate-sensitive Prostate Cancer.

RecruitingPhase 2
  • Michael E. DeBakey VA Medical Center, Houston
Ages 18 and older · Men · Updated Jun 15, 2026 · NCT05422911

Presurgical Phase II Study of Talazoparib in Combination With Enzalutamide in Prostate Cancer

RecruitingPhase 2
  • M D Anderson Cancer Center, Houston
Ages 18 and older · Men · Updated Jun 12, 2026 · NCT05873192

Long-Term Safety of Lutetium (177Lu) Vipivotide Tetraxetan in Participants With Prostate Cancer

RecruitingPhase 4
  • UT Health Science Center, Houston
Ages 18 to 100 · Men · Updated Jun 4, 2026 · NCT05803941

An Evidence-Based Focal Cryotherapy Protocol for Focal Ablation of Intermediate Risk Prostate Cancer

RecruitingPhase 2
  • MD Anderson Cancer Center, Houston
Ages 18 and older · Men · Updated Jun 2, 2026 · NCT05454488

Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors

RecruitingPhase 1/2
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated May 6, 2026 · NCT06239194

Older Men's Decision Making About Active Surveillance for Prostate Cancer - Aim 3: Decision Aid Cognitive and Usability Testing

RecruitingObservational study
  • M D Anderson Cancer Center, Houston
Ages 65 and older · Men · Updated Apr 16, 2026 · NCT05497024

Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME Trial

Recruiting
  • M D Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Apr 15, 2026 · NCT04693377

Veterans Affairs Seamless Phase II/III Randomized Trial of STAndard Systemic theRapy With or Without PET-directed Local Therapy for Oligometastatic pRosTate Cancer

RecruitingPhase 2/3
  • Michael E. DeBakey VA Medical Center, Houston, TX, Houston
Ages 18 and older · Men · Updated Apr 8, 2026 · NCT04787744

A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies

RecruitingPhase 1/2
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Mar 27, 2026 · NCT06395519

Neoadjuvant High Dose Rate Brachytherapy Prior to Radical Prostatectomy in Patients With Prostate Cancer

RecruitingPhase 1/2
  • Houston Methodist, Houston
Ages 40 and older · Men · Updated Mar 9, 2026 · NCT07182279

The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study

RecruitingObservational study
  • Md Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Mar 5, 2026 · NCT04075305

Study of AZD0754 in Participants With Metastatic Prostate Cancer

RecruitingPhase 1/2
  • Research Site, Houston
Ages 18 to 130 · Men · Updated Feb 23, 2026 · NCT06267729

A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

RecruitingPhase 1
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Feb 13, 2026 · NCT06778863

A Safety and Dose-finding Study of PRL-02 Depot in Men With Advanced Prostate Cancer

RecruitingPhase 1
  • Houston Metro Urology, Houston
Ages 18 and older · Men · Updated Feb 4, 2026 · NCT04729114

Testing Whether the Addition of Carboplatin Chemotherapy to Cabazitaxel Chemotherapy Will Improve Outcomes Compared to Cabazitaxel Alone in People With Castrate-Resistant Prostate Cancer That Has Spread Beyond the Prostate to Other Parts of the Body

RecruitingPhase 3
  • Lyndon Baines Johnson General Hospital, Houston
  • M D Anderson Cancer Center, Houston
  • MD Anderson West Houston, Houston
Ages 18 and older · Men · Updated Jan 22, 2026 · NCT06470243

A Study to Evaluate the Safety, Pharmacokinetics and Efficacy of TJ101 in Patients With Advanced/Metastatic Solid Tumors

RecruitingPhase 1
  • Oncology Consultants, Houston
Ages 18 and older · All sexes · Updated Jan 12, 2026 · NCT07181473

Evaluation of Response to Abiraterone/Prednisone by Race/Ethnicity and Other Factors in Metastatic Hormone Naive Prostate Cancer

RecruitingPhase 2
  • Ben Taub General Hospital, Houston
  • Dan L. Duncan Comprehensive Cancer Center at Baylor College of Medicine, Houston
Ages 18 and older · Men · Updated Dec 11, 2025 · NCT03833921

A Study of MT-4561 in Patients With Various Advanced Solid Tumors

RecruitingPhase 1/2
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Dec 11, 2025 · NCT06943521

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Houston
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer

RecruitingPhase 3
  • Lyndon Baines Johnson General Hospital, Houston
  • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston
  • Ben Taub General Hospital, Houston
  • and 3 more
Ages 18 and older · Men · Updated Sep 11, 2025 · NCT03678025

Comprehensive Assessment of Cancer Theranostic Response

Recruiting
  • M.D. Anderson Cancer Center, Houston
Ages 18 and older · Men · Updated Sep 9, 2025 · NCT06815354

A Phase 1 Study of XL309 (ISM3091) Alone and in Combination in Participants With Advanced Solid Tumors

RecruitingPhase 1
  • Exelixis Clinical Site #1, Houston
Ages 18 and older · All sexes · Updated Sep 5, 2025 · NCT05932862

Treatment of Patients With Progressive mCRPC With 177Lu-PSMA-617

RecruitingPhase 2
  • Excel Diagnostics & Nuclear Oncology Center, Houston
Ages 18 and older · Men · Updated May 15, 2025 · NCT06972628

A Trial of AMXI-5001 for Treatment in Patients With Advanced Malignancies

RecruitingPhase 1/2
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated May 1, 2025 · NCT04503265

Older Men's Decision Making About Active Surveillance for Prostate Cancer - Aim 3: Decision Aid Efficacy Testing

RecruitingObservational study
  • M.D. Anderson Cancer Center, Houston
Ages 65 and older · Men · Updated Feb 4, 2025 · NCT06785441

A Study of Evofosfamide in Combination with Zalifrelimab and Balstilimab

RecruitingPhase 1/2
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Jan 21, 2025 · NCT06782555

Comprehensive Outcomes for After Cancer Health

RecruitingHealthy volunteers welcome
  • The University of Texas MD Anderson Cancer Center, Houston
  • UT Health Houston, Houston
Ages 18 and older · All sexes · Updated Dec 11, 2024 · NCT05349227

Modifying Metabolic Syndrome and Cardiovascular Risk for Prostate Cancer Patients on ADT Using a Risk Factor Modification Program and Continuous Fitbit Monitoring

RecruitingPhase 2
  • M D Anderson Cancer Center, Houston
Ages 18 and older · Men · Updated Mar 29, 2023 · NCT05054296

Phase II High Risk Prostate Cancer Trial Using Gene & Androgen Deprivation Therapies, Radiotherapy, & Surgery

RecruitingPhase 2
  • Houston Methodist Hospital, Houston
Ages 18 and older · Men · Updated Apr 6, 2021 · NCT03541928

HSV-tk + Valacyclovir Therapy in Combination With Brachytherapy for Recurrent Prostate Cancer

RecruitingPhase 1/2
  • Houston Methodist, Houston
All ages · Men · Updated Jul 1, 2016 · NCT01913106

About Prostate Cancer

Prostate cancer is one of the most common types of cancer among American men. The risk goes up as men age. Learn about symptoms, tests, and treatment.

More about Prostate Cancer on MedlinePlus

Prostate Cancer trials in other cities

Other studies in Houston

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.