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Colorectal Cancer clinical trials in Jacksonville, FL

27 studies for Colorectal Cancer are looking for participants at sites in and around Jacksonville (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program

RecruitingPhase 2
  • Mayo Clinic in Florida, Jacksonville
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06265285

Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors

RecruitingPhase 1
  • Exelixis Clinical Site #78, Jacksonville
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT05176483

A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

RecruitingPhase 1
  • Research Site, Jacksonville
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT05877599

Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer

RecruitingPhase 3
  • Mayo Clinic Pharmacy, Jacksonville
  • Mayo Clinic, Jacksonville
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07222800

Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing

RecruitingObservational study
  • Mayo Clinic Jacksonville, Jacksonville
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT04981119

Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors

RecruitingPhase 1
  • Research Site, Jacksonville
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06218914

Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors

RecruitingPhase 1/2
  • Mayo Clinic Cancer Center, Jacksonville
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06445062

A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)

RecruitingPhase 1
  • Mayo Clinic in Florida, Jacksonville
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT04929223

Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation

RecruitingPhase 3
  • Cancer Specialists of North Florida - Southpoint, Jacksonville
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT06252649

Collecting Blood and Stool Samples to Detect Colorectal Cancer or Advanced Neoplasia in Lynch Syndrome Patients

RecruitingObservational study
  • Mayo Clinic in Florida, Jacksonville
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT05410977

FOG-001 in Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
  • Mayo Clinic, Jacksonville
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT05919264

A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
  • Mayo Clinic (Florida), Jacksonville
  • Cancer Specialists of North Florida, Jacksonville
Ages 18 and older · All sexes · Updated Jul 30, 2026 · NCT04657068

Phase I Study of [177Lu]Lu-NNS309 in Patients With Pancreatic, Lung, Breast and Colorectal Cancers

RecruitingPhase 1
  • Mayo Clinic Jacksonville, Jacksonville
Ages 18 to 100 · All sexes · Updated Jul 29, 2026 · NCT06562192

KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors

RecruitingPhase 1
  • Mayo Clinic Comprehensive Cancer Center, Jacksonville
Ages 18 and older · All sexes · Updated Jun 8, 2026 · NCT06026410

Smart Symptom Tracking ALEX Application for Tracking and Monitoring Gastrointestinal Health, Smart Horizons Pilot Trial

RecruitingHealthy volunteers welcome
  • Mayo Clinic in Florida, Jacksonville
Ages 18 to 44 · All sexes · Updated Jun 5, 2026 · NCT07618273

Intravital Microscopy in Human Solid Tumors

Recruiting
  • Mayo Clinic Florida, Jacksonville
Ages 18 and older · All sexes · Updated Jun 2, 2026 · NCT03823144

A Multilevel Approach to Connecting Underrepresented Populations to Clinical Trials

RecruitingObservational studyHealthy volunteers welcome
  • Mayo Clinic in Florida, Jacksonville
Ages 18 to 100 · All sexes · Updated May 8, 2026 · NCT05655494

A Study to Investigate the Safety and Efficacy of KQB365 as Monotherapy and in Combination in Participants With Advanced Solid Malignancies

RecruitingPhase 1
  • Mayo Clinic, Jacksonville, Jacksonville
Ages 18 and older · All sexes · Updated Apr 23, 2026 · NCT06720987

A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies

RecruitingPhase 1/2
  • Mayo Clinic, Jacksonville
Ages 18 and older · All sexes · Updated Mar 27, 2026 · NCT06395519

Immune Checkpoint Inhibitor Response in Solid Tumors Using a Live Tumor Diagnostic Platform

RecruitingObservational study
  • Mayo Clinic in Florida, Jacksonville
Ages 18 and older · All sexes · Updated Mar 12, 2026 · NCT06349642

About Colorectal Cancer

Colorectal cancer starts in the colon or rectum. It may not cause symptoms at first. Screening tests can help find it early, when treatment is most effective.

More about Colorectal Cancer on MedlinePlus

Colorectal Cancer trials in other cities

Other studies in Jacksonville

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.