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Colorectal Cancer clinical trials in San Antonio, TX

46 studies for Colorectal Cancer are looking for participants at sites in and around San Antonio (within about 30 miles). Open a study to see who can join and how to contact the study team.

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The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
  • New Experimental Therapeutics of San Antonio - NEXT Oncology, San Antonio
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • Audie L Murphy VA Hospital, San Antonio
Ages 40 to 75 · All sexes · Updated Oct 2, 2026 · NCT05334069

Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

RecruitingPhase 1
  • University of Texas San Antonio (UTSA), San Antonio
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06625775

A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy

RecruitingPhase 3
  • Texas Oncology - San Antonio, San Antonio
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06750094

A Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of VVD-133214 as Monotherapy and in Combination in Participants With Advanced Solid Tumors

RecruitingPhase 1
  • START San Antonio, San Antonio
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06004245

Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

RecruitingPhase 1/2
  • NEXT Oncology San Antonio, San Antonio
  • START Texas, San Antonio
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06128551

Study of RMC-5127 in Patients With Advanced KRAS G12V-Mutant Solid Tumors

RecruitingPhase 1
  • NEXT, San Antonio
  • START - San Antonio, San Antonio
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07349537

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

RecruitingPhase 1/2
  • START San Antonio, San Antonio
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT05786924

A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors

RecruitingPhase 1
  • NEXT Oncology, San Antonio
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06440005

A Randomized Phase 2 Trial of Fruquintinib and TAS-102 as Compared to Fruquintinib in Patients With Refractory Advanced/Metastatic Colorectal Cancer

RecruitingPhase 2
  • Mays Cancer Center at University of Texas Health at San Antonio, San Antonio
Ages 18 and older · All sexes · Updated Sep 1, 2026 · NCT06992258

A Study of STRO-004 in Adults With Refractory/Recurrent Metastatic Cancer

RecruitingPhase 1
  • NEXT San Antonio, San Antonio
Ages 18 and older · All sexes · Updated Aug 27, 2026 · NCT07227168

MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors

RecruitingPhase 1
  • South Texas Accelerated Research Therapeutics (START), San Antonio
Ages 18 and older · All sexes · Updated Aug 24, 2026 · NCT06586515

FOG-001 in Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
  • South Texas Accelerated Research Therapeutics, LLC, San Antonio
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT05919264

A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • UT Health Mays Cancer Center, San Antonio
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT05592626

A Study to Evaluate ARV-6723 Alone and With Pembrolizumab in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • Clinical Trial Site, San Antonio
Ages 18 and older · All sexes · Updated Aug 6, 2026 · NCT07749586

IDOV-Immune for Advanced Solid Tumors

RecruitingPhase 1
  • South Texas Accelerated Research Therapeutics, San Antonio
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT06910657

Study of RAS(ON) Inhibitors in Combination With Ivonescimab in Patients With Solid Tumors

RecruitingPhase 1/2
  • NEXT Oncology, San Antonio
Ages 18 and older · All sexes · Updated Aug 3, 2026 · NCT07397338

A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
  • Texas Oncology - San Antonio, San Antonio
Ages 18 and older · All sexes · Updated Jul 30, 2026 · NCT04657068

AMG 410 Alone and in Combination With Other Agents in Participants With KRAS Altered Advanced or Metastatic Solid Tumors

RecruitingPhase 1
  • Next Oncology, San Antonio
Ages 18 and older · All sexes · Updated Jul 30, 2026 · NCT07094113

A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors

RecruitingPhase 1
  • South Texas Accelerated Research Therapeutics, LLC, San Antonio
Ages 18 and older · All sexes · Updated Jul 22, 2026 · NCT06131840

A Study to Learn About the Study Medicine Called PF-08032562 in People With Advanced or Metastatic Solid Tumors

RecruitingPhase 1
  • START San Antonio, San Antonio
Ages 18 and older · All sexes · Updated Jul 22, 2026 · NCT07318805

A Study of CHS-114 (Tagmokitug) in Combination With Toripalimab and/or Other Treatments in Participants With Advanced Solid Tumors

RecruitingPhase 1
  • START San Antonio, LLC., San Antonio
Ages 18 and older · All sexes · Updated Jul 15, 2026 · NCT06657144

A Study of PT0511 in Participants With KRAS Mutated or Amplified Advanced Solid Tumors

RecruitingPhase 1
  • New Experimental Therapeutics of San Antonio LLC, San Antonio
  • START - South Texas Accelerated Research Therapeutics, LLC, San Antonio
Ages 18 and older · All sexes · Updated Jul 6, 2026 · NCT07300150

A Study to Investigate ALE.P03 as Monotherapy in Adult Patients With Selected Advanced or Metastatic CLDN1+ Solid Tumors

RecruitingPhase 1/2
  • Next Oncology-Oncology, San Antonio
Ages 18 and older · All sexes · Updated Jul 2, 2026 · NCT07169734

A Phase 1 Dose-escalation Trial of KST-6051 in Participants With Advanced Solid Tumors With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Mutation

RecruitingPhase 1
  • NEXT Oncology, San Antonio
Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT07458347

A Study of IDE034 in Adult Participants With Locally Advanced/Metastatic Solid Tumors Types

RecruitingPhase 1
  • NEXT Texas LLC - San Antonio, San Antonio
  • START San Antonio, LLC, San Antonio
Ages 18 and older · All sexes · Updated Jun 18, 2026 · NCT07503808

A Study to Investigate the Safety, Pharmacokinetics, and Preliminary Efficacy of IDE574 Therapy in Adult Participants With Advanced Solid Tumors

RecruitingPhase 1
  • NEXT Texas LLC - San Antonio, San Antonio
  • Start San Antonio, LLC, San Antonio
Ages 18 to 99 · All sexes · Updated Jun 16, 2026 · NCT07540572

CT-95 in Advanced Cancers Associated With Mesothelin Expression

RecruitingPhase 1
  • Context Investigational Site, San Antonio
  • Context Investigational Site, San Antonio
Ages 18 and older · All sexes · Updated Jun 12, 2026 · NCT06756035

A Study to Learn About Study Medicine ALTA3263 in Adults With Advanced Solid Tumors With KRAS Mutations

RecruitingPhase 1
  • Research Site #2, San Antonio
  • Research Site, San Antonio
Ages 18 and older · All sexes · Updated Jun 10, 2026 · NCT06835569

Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

RecruitingPhase 1
  • START, San Antonio
Ages 18 and older · All sexes · Updated Jun 3, 2026 · NCT06040541

BBO-11818 in Adult Subjects With KRAS Mutant Cancer

RecruitingPhase 1
  • NEXT Oncology, San Antonio
Ages 18 and older · All sexes · Updated Jun 2, 2026 · NCT06917079

A Study to Evaluate the Safety, Tolerability, and Efficacy of BMS-986523 Alone and in Combination With Anti-Cancer Agents in Participants With Advanced Solid Malignancies

RecruitingPhase 1/2
  • NEXT Oncology, San Antonio
Ages 18 and older · All sexes · Updated May 28, 2026 · NCT07223047

Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

RecruitingPhase 1/2
  • Next Oncology, San Antonio
Ages 18 and older · All sexes · Updated May 15, 2026 · NCT05379985

A Study of MGC028 in Participants With Advanced Solid Tumors

RecruitingPhase 1
  • South Texas Accelerated Research Therapeutics (START) San Antonio, San Antonio
Ages 18 and older · All sexes · Updated Apr 27, 2026 · NCT06723236

A Study of TSN1611 Treating Patients With Advanced Solid Tumors Harboring KRAS G12D Mutation

RecruitingPhase 1/2
  • NEXT Oncology, San Antonio
Ages 18 to 75 · All sexes · Updated Apr 24, 2026 · NCT06385925

A Study to Investigate the Safety and Efficacy of KQB365 as Monotherapy and in Combination in Participants With Advanced Solid Malignancies

RecruitingPhase 1
  • NEXT Oncology, San Antonio
Ages 18 and older · All sexes · Updated Apr 23, 2026 · NCT06720987

A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors

RecruitingPhase 1/2
  • South Texas Accelerated Research Therapeutics, LLC, San Antonio
  • UT Health San Antonio, San Antonio
Ages 18 and older · All sexes · Updated Mar 18, 2026 · NCT06244771

Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
  • START San Antonio, San Antonio
Ages 18 and older · All sexes · Updated Feb 18, 2026 · NCT07030257

Phase 1/2 Dose Finding, Safety and PK Study in Advanced Refractory Solid Tumors

RecruitingPhase 1/2
  • START San Antonio, San Antonio
Ages 18 and older · All sexes · Updated Feb 17, 2026 · NCT07145255

Phase 1/2a Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of WEF-001 as Monotherapy in Advanced KRAS-Mutant Solid Tumours.

RecruitingPhase 1/2
  • Next Oncology, San Antonio, San Antonio
Ages 18 and older · All sexes · Updated Jan 29, 2026 · NCT07148128

About Colorectal Cancer

Colorectal cancer starts in the colon or rectum. It may not cause symptoms at first. Screening tests can help find it early, when treatment is most effective.

More about Colorectal Cancer on MedlinePlus

Colorectal Cancer trials in other cities

Other studies in San Antonio

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.