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Sickle Cell Disease clinical trials in Birmingham, AL

14 studies for Sickle Cell Disease are looking for participants at sites in and around Birmingham (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

A Phase 1b, Open-Label Study of DISC-3405 in Participants With Sickle Cell Disease (SCD)

RecruitingPhase 1
  • University of Alabama at Birmingham, Birmingham
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07187973

A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease

RecruitingPhase 3
  • Uni of Alabama at Birmingham, Birmingham
Ages 12 and older · All sexes · Updated Sep 17, 2026 · NCT06612268

A Phase I/II Study of ITU512 in Healthy Participants and Patients With Sickle Cell Disease

RecruitingPhase 1/2Healthy volunteers welcome
  • University of Alabama Birmingham, Birmingham
Ages 12 to 55 · All sexes · Updated Sep 9, 2026 · NCT06546670

SCD Stem Cell Mobilization and Apheresis Using Motixafortide

RecruitingPhase 1
  • University of Alabama at Birmingham, Birmingham
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT06442761

A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease

RecruitingPhase 1/2Healthy volunteers welcome
  • University of Alabama at Birmingham, Birmingham
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT06481306

The Efficacy and Safety of Rilzabrutinib in Participants Aged 10 to 65 Years With Sickle-cell Disease

RecruitingPhase 3
  • University of Alabama at Birmingham- Site Number : 8400003, Birmingham
Ages 10 to 65 · All sexes · Updated Jul 29, 2026 · NCT06975865

Early Life Exposures Among Children With Sickle Cell Disease

Recruiting
  • University of Alabama at Birmingham, Birmingham
Ages 18 to 50 · Women · Updated Jul 15, 2026 · NCT05377372

Rollover Study for Patients With Sickle Cell Disease Who Have Completed a Prior Novartis-Sponsored Crizanlizumab Study

RecruitingPhase 4
  • University Of Alabama, Birmingham
6 Months – 100 Years · All sexes · Updated Jun 8, 2026 · NCT04657822

Comparing the Effectiveness of Matched Related Donor Hematopoietic Stem Cell Transplantation to Disease Modifying Therapy in Pediatric Patients With Sickle Cell Disease

RecruitingObservational study
  • Children's of Alabama (MRD-HCT), Birmingham
  • Children's of Alabama (NT-DMT), Birmingham
Ages 3 to 20 · All sexes · Updated Jun 4, 2026 · NCT06941389

Cognitive Remediation Intervention to Prepare for Transition of Care

RecruitingPhase 2
  • University of Alabama at Birmingham, Birmingham
Ages 10 to 18 · All sexes · Updated Feb 27, 2026 · NCT05336201

A Long-term Follow-up Study in Patients Who Received BEAM-101

RecruitingObservational study
  • University of Alabama at Birmingham, Birmingham
Ages 14 to 37 · All sexes · Updated Jan 28, 2026 · NCT07373639

HPC Offered for PRESERVE Expansion

RecruitingObservational study
  • University of Alabama, Birmingham, Birmingham
Ages 12 to 80 · All sexes · Updated Aug 28, 2025 · NCT07145411

Recruitment and Engagement in Care to Impact Practice Enhancement (RECIPE) for Sickle Cell Disease

RecruitingObservational study
  • University of Alabama, Birmingham (UAB), Birmingham
Ages 18 and older · All sexes · Updated Jun 22, 2025 · NCT06385886

About Sickle Cell Disease

Sickle cell disease is a group of inherited disorders that affect your red blood cells. It can cause pain, anemia, and other problems. Learn about treatments.

More about Sickle Cell Disease on MedlinePlus

Sickle Cell Disease trials in other cities

Other studies in Birmingham

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.