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Brain Tumors clinical trials recruiting in the U.S.
197 studies for Brain Tumors are recruiting participants at sites across the United States.
A brain tumor is a growth of abnormal cells in the brain tissue. Learn the types of tumors, symptoms, how they are diagnosed and treatment options.
Cities with the most studies
- Houston, TX35 studies
- Boston, MA28 studies
- New York City, NY25 studies
- Washington, DC20 studies
- Los Angeles, CA16 studies
- Miami, FL15 studies
- Durham, NC14 studies
- St. Louis, MO12 studies
- Seattle, WA11 studies
- Cleveland, OH11 studies
- Rochester, MN11 studies
- Baltimore, MD11 studies
- Columbus, OH11 studies
- Chicago, IL11 studies
- Ann Arbor, MI10 studies
- Aurora, CO9 studies
- Atlanta, GA9 studies
- Detroit, MI9 studies
- Nashville, TN8 studies
- Arlington, VA8 studies
- San Francisco, CA8 studies
- Minneapolis, MN8 studies
- Portland, OR8 studies
- Dallas, TX8 studies
- San Antonio, TX7 studies
- Philadelphia, PA7 studies
- Salt Lake City, UT7 studies
- Mountain View, CA7 studies
- San Diego, CA7 studies
- Cincinnati, OH7 studies
- Baldwin Park, CA7 studies
- Jacksonville, FL7 studies
- Tampa, FL6 studies
- Birmingham, AL5 studies
- Madison, WI5 studies
- Winston-Salem, NC5 studies
- Scottsdale, AZ5 studies
- Milwaukee, WI5 studies
- Memphis, TN4 studies
- Grand Rapids, MI4 studies
By state
- Alabama5 studies
- Arizona11 studies
- Arkansas3 studies
- California39 studies
- Colorado11 studies
- District of Columbia13 studies
- Florida29 studies
- Georgia12 studies
- Idaho3 studies
- Illinois14 studies
- Indiana4 studies
- Iowa4 studies
- Kansas3 studies
- Kentucky5 studies
- Maryland18 studies
- Massachusetts29 studies
- Michigan19 studies
- Minnesota18 studies
- Missouri13 studies
- Montana3 studies
- Nebraska5 studies
- New Hampshire4 studies
- New Jersey8 studies
- New York35 studies
- North Carolina20 studies
- Ohio23 studies
- Oklahoma3 studies
- Oregon8 studies
- Pennsylvania13 studies
- Rhode Island3 studies
- South Carolina5 studies
- Tennessee12 studies
- Texas42 studies
- Utah8 studies
- Virginia15 studies
- Washington12 studies
- Wisconsin11 studies
Recently updated studies
Ruxolitinib With Radiation and Temozolomide Compared to Radiation and Temozolomide for Newly Diagnosed Glioblastoma
RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Oct 2, 2026 ยท NCT06991101Tumor Related Epilepsy
RecruitingObservational study
Ages 8 to 99 ยท All sexes ยท Updated Oct 2, 2026 ยท NCT02639325SRS Compared With FSRS for Treatment of Intact Metastatic Brain Disease, FRACTIONATE Trial
RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Oct 1, 2026 ยท NCT05222620GPC-3 CAR T CELLS FOR Recurrent GPC-3 Positive Glioblastoma
RecruitingPhase 1
Ages 21 to 70 ยท All sexes ยท Updated Sep 30, 2026 ยท NCT06815432Panitumumab-IRDye800 to Detect Pediatric Neoplasms During Neurosurgical Procedures
RecruitingPhase 1/2
6 Months โ 25 Years ยท All sexes ยท Updated Sep 29, 2026 ยท NCT04085887Evaluation and Treatment of Neurosurgical Disorders
RecruitingObservational study
Ages 4 to 99 ยท All sexes ยท Updated Sep 29, 2026 ยท NCT00060541Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII
RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Sep 28, 2026 ยท NCT07326566Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma
RecruitingPhase 1/2
Ages 18 to 99 ยท All sexes ยท Updated Sep 28, 2026 ยท NCT07416188SRS & Abemaciclib w/wo Imlunestrant in the Management of HR+/HER2- Breast CA Brain Metastases
RecruitingPhase 1/2
Ages 18 and older ยท All sexes ยท Updated Sep 28, 2026 ยท NCT04923542C-SMART vs BE Well for Patients With Brain Tumors
Recruiting
Ages 18 and older ยท All sexes ยท Updated Sep 25, 2026 ยท NCT07224503Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis
RecruitingPhase 1/2
Ages 18 and older ยท All sexes ยท Updated Sep 24, 2026 ยท NCT06047379RNA-Lipid Particle (RNA-LP) Vaccines for Recurrent Adult Glioblastoma (GBM)
RecruitingPhase 1
Ages 18 to 80 ยท All sexes ยท Updated Sep 23, 2026 ยท NCT06389591Extracellular Impact of Ultrasound-induced Blood-brain Barrier Disruption
Recruiting
Ages 18 and older ยท All sexes ยท Updated Sep 23, 2026 ยท NCT05733312Memory Avoidance Whole Brain Radiotherapy vs Hippocampal Avoidance Whole Brain Radiotherapy (Athena 2 Trial)
RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Sep 22, 2026 ยท NCT07248228Memantine +/- Raloxifene for Cognitive Preservation After Radiation Therapy to the Brain
RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Sep 22, 2026 ยท NCT07470606REMIND Maintenance Radiotherapy for Newly Diagnosed Glioblastoma
Recruiting
Ages 18 and older ยท All sexes ยท Updated Sep 21, 2026 ยท NCT07831772Trial of Anti-PD-1 Immunotherapy and Stereotactic Radiation in Patients With Recurrent Glioblastoma
RecruitingPhase 1/2
Ages 18 and older ยท All sexes ยท Updated Sep 21, 2026 ยท NCT04977375Feasibility of 18F-Fluciclovine PET/CT to Identify Brain Metastasis
RecruitingEarly phase 1
Ages 18 to 99 ยท All sexes ยท Updated Sep 21, 2026 ยท NCT06055790PilotStudyAssessSafeActiveSurveillancApproachLocalThe Pa w/BrainMetsUndergoinCNSPenetratSystemicThe
RecruitingObservational study
Ages 18 and older ยท All sexes ยท Updated Sep 18, 2026 ยท NCT07827001Laser Interstitial Thermal Therapy (LITT) or Surgery and Adjuvant Reirradiation for Recurrent Brain Metastases (LaSAR BeaM)
RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Sep 18, 2026 ยท NCT07053033Brain Metastases in Greater Size - Hypofractionated Options Trial (BIGSHOT)
RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Sep 18, 2026 ยท NCT07227610A Phase II Study of Nivolumab With Ipilimumab and Cabozantinib in Patients With Untreated Renal Cell Carcinoma Brain Metastases
RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Sep 18, 2026 ยท NCT05048212Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies
RecruitingPhase 1/2
Ages 18 and older ยท All sexes ยท Updated Sep 16, 2026 ยท NCT05786924A Study of BMS-986504 Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)
RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Sep 16, 2026 ยท NCT07492680A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases
RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Sep 15, 2026 ยท NCT04511013From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.