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Brain Tumors clinical trials recruiting in the U.S.

197 studies for Brain Tumors are recruiting participants at sites across the United States.

A brain tumor is a growth of abnormal cells in the brain tissue. Learn the types of tumors, symptoms, how they are diagnosed and treatment options.

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Recently updated studies

Ruxolitinib With Radiation and Temozolomide Compared to Radiation and Temozolomide for Newly Diagnosed Glioblastoma

RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Oct 2, 2026 ยท NCT06991101

Tumor Related Epilepsy

RecruitingObservational study
Ages 8 to 99 ยท All sexes ยท Updated Oct 2, 2026 ยท NCT02639325

SRS Compared With FSRS for Treatment of Intact Metastatic Brain Disease, FRACTIONATE Trial

RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Oct 1, 2026 ยท NCT05222620

GPC-3 CAR T CELLS FOR Recurrent GPC-3 Positive Glioblastoma

RecruitingPhase 1
Ages 21 to 70 ยท All sexes ยท Updated Sep 30, 2026 ยท NCT06815432

Panitumumab-IRDye800 to Detect Pediatric Neoplasms During Neurosurgical Procedures

RecruitingPhase 1/2
6 Months โ€“ 25 Years ยท All sexes ยท Updated Sep 29, 2026 ยท NCT04085887

Evaluation and Treatment of Neurosurgical Disorders

RecruitingObservational study
Ages 4 to 99 ยท All sexes ยท Updated Sep 29, 2026 ยท NCT00060541

Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII

RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Sep 28, 2026 ยท NCT07326566

Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma

RecruitingPhase 1/2
Ages 18 to 99 ยท All sexes ยท Updated Sep 28, 2026 ยท NCT07416188

SRS & Abemaciclib w/wo Imlunestrant in the Management of HR+/HER2- Breast CA Brain Metastases

RecruitingPhase 1/2
Ages 18 and older ยท All sexes ยท Updated Sep 28, 2026 ยท NCT04923542

C-SMART vs BE Well for Patients With Brain Tumors

Recruiting
Ages 18 and older ยท All sexes ยท Updated Sep 25, 2026 ยท NCT07224503

Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis

RecruitingPhase 1/2
Ages 18 and older ยท All sexes ยท Updated Sep 24, 2026 ยท NCT06047379

RNA-Lipid Particle (RNA-LP) Vaccines for Recurrent Adult Glioblastoma (GBM)

RecruitingPhase 1
Ages 18 to 80 ยท All sexes ยท Updated Sep 23, 2026 ยท NCT06389591

Extracellular Impact of Ultrasound-induced Blood-brain Barrier Disruption

Recruiting
Ages 18 and older ยท All sexes ยท Updated Sep 23, 2026 ยท NCT05733312

Memory Avoidance Whole Brain Radiotherapy vs Hippocampal Avoidance Whole Brain Radiotherapy (Athena 2 Trial)

RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Sep 22, 2026 ยท NCT07248228

Memantine +/- Raloxifene for Cognitive Preservation After Radiation Therapy to the Brain

RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Sep 22, 2026 ยท NCT07470606

REMIND Maintenance Radiotherapy for Newly Diagnosed Glioblastoma

Recruiting
Ages 18 and older ยท All sexes ยท Updated Sep 21, 2026 ยท NCT07831772

Trial of Anti-PD-1 Immunotherapy and Stereotactic Radiation in Patients With Recurrent Glioblastoma

RecruitingPhase 1/2
Ages 18 and older ยท All sexes ยท Updated Sep 21, 2026 ยท NCT04977375

Feasibility of 18F-Fluciclovine PET/CT to Identify Brain Metastasis

RecruitingEarly phase 1
Ages 18 to 99 ยท All sexes ยท Updated Sep 21, 2026 ยท NCT06055790

PilotStudyAssessSafeActiveSurveillancApproachLocalThe Pa w/BrainMetsUndergoinCNSPenetratSystemicThe

RecruitingObservational study
Ages 18 and older ยท All sexes ยท Updated Sep 18, 2026 ยท NCT07827001

Laser Interstitial Thermal Therapy (LITT) or Surgery and Adjuvant Reirradiation for Recurrent Brain Metastases (LaSAR BeaM)

RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Sep 18, 2026 ยท NCT07053033

Brain Metastases in Greater Size - Hypofractionated Options Trial (BIGSHOT)

RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Sep 18, 2026 ยท NCT07227610

A Phase II Study of Nivolumab With Ipilimumab and Cabozantinib in Patients With Untreated Renal Cell Carcinoma Brain Metastases

RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Sep 18, 2026 ยท NCT05048212

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

RecruitingPhase 1/2
Ages 18 and older ยท All sexes ยท Updated Sep 16, 2026 ยท NCT05786924

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.