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Prostate Cancer clinical trials in St. Louis, MO
46 studies for Prostate Cancer are looking for participants at sites in and around St. Louis (within about 30 miles). Open a study to see who can join and how to contact the study team.
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Testing the Addition of Docetaxel (Chemotherapy) to the Usual Treatment (Hormonal Therapy and Apalutamide) for Metastatic Prostate Cancer, ASPIRE Trial
RecruitingPhase 3
- Washington University School of Medicine, St Louis
- Veteran's Affairs Medical Center - Saint Louis, St Louis
- Mercy Hospital South, St Louis
- and 7 more
Testing Different Dosing Schedules of the Anti-cancer Drug, Lutetium 177Lu PSMA RLT and Its Effect on Patients With Advanced Prostate Cancer, RECIPROCAL Trial
RecruitingPhase 3
- Missouri Baptist Medical Center, St Louis
- Cancer Care Center of O'Fallon, O'Fallon · 16 mi away
- HSHS Saint Elizabeth's Hospital, O'Fallon · 16 mi away
A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
RecruitingPhase 1
- Washington University School of Medicine in St. Louis, St Louis
Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
RecruitingObservational studyHealthy volunteers welcome
- Mercy Infusion Center - Chippewa, St Louis
- Mercy Hospital South, St Louis
- Missouri Baptist Medical Center, St Louis
- and 4 more
Targeted Treatment for Metastatic Prostate Cancer, The PREDICT Trial
RecruitingPhase 2
- Washington University School of Medicine, St Louis
- Siteman Cancer Center-South County, St Louis
- Siteman Cancer Center at Christian Hospital, St Louis
- and 3 more
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
RecruitingPhase 2
- Washington University, School of Medicine, St Louis
Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors
RecruitingPhase 2
- Washington University School of Medicine, St Louis
- Mercy Hospital South, St Louis
- Siteman Cancer Center-South County, St Louis
- and 5 more
Impact of Fluciclovine (18F) PET (Positron Emission Tomography) on the Management of Prostate Cancer Following Negative or Equivocal PSMA (Prostate-Specific Membrane Antigen) PET Imaging at the Time of Biochemical Recurrence
RecruitingPhase 4
- Washington University, St Louis
This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.
RecruitingPhase 3
- Cancer Care Specialists of Illinois, O'Fallon · 16 mi away
Open-label Study Comparing AAA817 Versus Standard of Care in the Treatment of Previously Treated PSMA-positive mCRPC Adults Who Have Disease Progressed on or After [177Lu]Lu-PSMA Targeted Therapy
RecruitingPhase 2/3
- WA Uni School Of Med, St Louis
A Study of LY4257496 in Participants With Cancer (OMNIRAY)
RecruitingPhase 1
- Washington University, St Louis
Study Comparing AAA817+ARPI Versus Standard of Care in Adult Participants With PSMA-positive mCRPC
RecruitingPhase 3
- Wash U School of Medicine, St Louis
High Dose Testosterone for ATM, CDK12 or CHEK2 Altered Prostate Cancers
RecruitingPhase 2
- St. Louis VA Medical Center John Cochran Division, St. Louis, MO, St Louis
Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer
RecruitingPhase 3
- Washington University School of Medicine, St Louis
- Siteman Cancer Center-South County, St Louis
- Missouri Baptist Medical Center, St Louis
- and 7 more
Daily Adaptive Radiation Therapy Using an Individualized Approach for Prostate Cancer
Recruiting
- Washington University in St. Louis, St Louis
A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors
RecruitingPhase 1
- Washington University School of Medicine, St Louis
Study of JANX014 in Subjects With Metastatic Castration-Resistant Prostate Cancer
RecruitingPhase 1
- Washington University School of Medicine, St Louis
The Vanguard Study: Testing a New Way to Screen for Cancer
RecruitingHealthy volunteers welcome
- Washington University School of Medicine, St Louis
AZD2265 Compared With Standard of Care in PSMA-positive Metastatic Castration-resistant Prostate Cancer (VECTRA-01)
RecruitingPhase 3
- Research Site, St Louis
- Research Site, O'Fallon · 16 mi away
A Single-Arm Phase II Study of Neoadjuvant Intensified Androgen Deprivation (Leuprolide and Abiraterone Acetate) in Combination With AKT Inhibition (Capivasertib) for High-Risk Localized Prostate Cancer With PTEN Loss
RecruitingPhase 2
- St. Louis VA Medical Center John Cochran Division, St. Louis, MO, St Louis
Study of AMG 509 in Participants With Metastatic Castration-Resistant Prostate Cancer
RecruitingPhase 1
- Washington University, St Louis
A Phase 1b/2a Study of Pocenbrodib as Monotherapy and in Combination With Darolutamide in Participants With mCRPC
RecruitingPhase 1/2
- Siteman Cancer Center, St Louis
Impact of an Electronic Health Record Maintenance Alert on PSA Screening Rates in a 10-Hospital Integrated Health System
RecruitingHealthy volunteers welcome
- Washington University School of Medicine, St Louis
Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging
RecruitingPhase 3
- Washington University School of Medicine, St Louis
- Mercy Hospital South, St Louis
- Siteman Cancer Center-South County, St Louis
- and 8 more
FOG-001 in Locally Advanced or Metastatic Solid Tumors
RecruitingPhase 1/2
- Washington University School of Medicine, St Louis
Study of JANX007 in Subjects With Metastatic Castration-Resistant Prostate Cancer (ENGAGER-PSMA-01)
RecruitingPhase 1
- Washington University School of Medicine, St Louis
IDOV-Immune for Advanced Solid Tumors
RecruitingPhase 1
- Washington University School of Medicine, St Louis
Evaluation of Neoadjuvant Xaluritamig in Localized Prostate Cancer
RecruitingPhase 1
- Washington University, St Louis
Study of Orally Administered MOMA-313 in Participants With Advanced or Metastatic Solid Tumors
RecruitingPhase 1
- Investigative Site #110, St Louis
PSMA PET Combined With MRI for the Detection of PCa
RecruitingPhase 3Healthy volunteers welcome
- Washington University, St Louis
Low-Count Quantitative SPECT for Men Treated With Radium-223
Recruiting
- Washington University School of Medicine, St Louis
Docetaxel to Androgen Receptor Pathway Inhibitors in Patients With Metastatic Castration Sensitive Prostate Cancer and Suboptimal PSA Response
RecruitingPhase 3
- Washington University School of Medicine, St Louis
- Siteman Cancer Center-South County, St Louis
- Siteman Cancer Center at Christian Hospital, St Louis
- and 2 more
Diffusion Basis Spectrum Imaging of the Prostate
Recruiting
- Washington University School of Medicine, St Louis
CARE Tool Study Aim 3
Recruiting
- Washington University School of Medicine, St Louis
- Alton Memorial Hospital, Alton · 18 mi away
Postoperative or Salvage Radiotherapy (RT) for Node Negative Prostate Cancer Following Radical Prostatectomy
Recruiting
- Mercy David C. Pratt Cancer Center, St Louis
Abiraterone, Enzalutamide, or Apalutamide in Castrate-sensitive Prostate Cancer.
RecruitingPhase 2
- VA St. Louis Health Care System, St Louis
Neoadjuvant Atezolizumab-Based Combination Therapy in Men With Localized Prostate Cancer Prior to Radical Prostatectomy
RecruitingPhase 2
- Alvin J. Siteman Cancer Center at Washington University, St Louis
Long-Term Safety of Lutetium (177Lu) Vipivotide Tetraxetan in Participants With Prostate Cancer
RecruitingPhase 4
- Wash U School of Medicine, St Louis
Androgen Suppression Combined With Nodal Irradiation and Dose Escalated Prostate Treatment
RecruitingPhase 3
- Washington University School of Medicine, St Louis
- Siteman Cancer Center-South County, St Louis
- Siteman Cancer Center at Christian Hospital, St Louis
- and 2 more
Safety and Efficacy of 21 Gy, 23 Gy and 25 Gy for High Dose Rate (HDR) Prostate Brachytherapy
RecruitingPhase 1/2
- Washington University School of Medicine, St Louis
Study of AZD0754 in Participants With Metastatic Prostate Cancer
RecruitingPhase 1/2
- Research Site, St Louis
Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors
RecruitingObservational studyHealthy volunteers welcome
- Washington University School of Medicine, St Louis
Testing Whether the Addition of Carboplatin Chemotherapy to Cabazitaxel Chemotherapy Will Improve Outcomes Compared to Cabazitaxel Alone in People With Castrate-Resistant Prostate Cancer That Has Spread Beyond the Prostate to Other Parts of the Body
RecruitingPhase 3
- Missouri Baptist Medical Center, St Louis
- BJC Outpatient Center at Sunset Hills, Sunset Hills · 13 mi away
- Cancer Care Center of O'Fallon, O'Fallon · 16 mi away
- and 1 more
Vitamin D for Prostate Endocrine Therapy
RecruitingPhase 3
- Mercy Hospital Saint Louis, St Louis
- Cancer Care Center of O'Fallon, O'Fallon · 16 mi away
SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
RecruitingObservational study
- Massive Bio SYNERGY-AI site, St Louis
Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer
RecruitingPhase 3
- Washington University School of Medicine, St Louis
- Siteman Cancer Center-South County, St Louis
- Missouri Baptist Medical Center, St Louis
- and 3 more
About Prostate Cancer
Prostate cancer is one of the most common types of cancer among American men. The risk goes up as men age. Learn about symptoms, tests, and treatment.
More about Prostate Cancer on MedlinePlus
Prostate Cancer trials in other cities
- New York City, NY103 studies
- Houston, TX76 studies
- Los Angeles, CA61 studies
- Boston, MA59 studies
- Chicago, IL45 studies
- San Francisco, CA45 studies
- Philadelphia, PA44 studies
- Baltimore, MD43 studies
- Nashville, TN42 studies
- Seattle, WA42 studies
- Washington, DC38 studies
- Dallas, TX36 studies
Other studies in St. Louis
- Non-Small Cell Lung Cancer73 studies
- Breast Cancer64 studies
- Metastatic Cancer54 studies
- Colorectal Cancer50 studies
- Cancer (all types)46 studies
- Lung Cancer39 studies
- Ovarian Cancer38 studies
- Pancreatic Cancer33 studies
- Endometrial Cancer29 studies
- Head and Neck Squamous Cell Carcinoma28 studies
- Heart Failure26 studies
- Obesity25 studies
From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.