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Acute Myeloid Leukemia clinical trials in Boston, MA

44 studies for Acute Myeloid Leukemia are looking for participants at sites in and around Boston (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Testing the Anti-cancer Drug, Cirtuvivint, and Its Combination With ASTX727 to Improve Outcomes in Patients With Acute Myeloid Leukemia and Myelodysplastic Syndromes

RecruitingPhase 1
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06484062

Comparing Cytarabine + Daunorubicin Therapy Versus Cytarabine + Daunorubicin + Venetoclax Versus Venetoclax + Azacitidine in Younger Patients With Intermediate Risk AML (A MyeloMATCH Treatment Trial)

RecruitingPhase 2
  • Tufts Medical Center, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 to 59 · All sexes · Updated Sep 28, 2026 · NCT05554393

A Study of Bleximenib, Venetoclax and Azacitidine For Treatment of Participants With Newly Diagnosed Acute Myeloid Leukemia (AML)

RecruitingPhase 3
  • Dana Farber Cancer Institute, Boston
  • Beth Israel Deaconess Medical Center, Boston
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06852222

MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

RecruitingPhase 2
  • Tufts Medical Center, Boston
  • Beth Israel Deaconess Medical Center, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT05564390

Venetoclax and HMA Treatment of Older and Unfit Adults With FLT3 Mutated Acute Myeloid Leukemia (AML) (A MyeloMATCH Treatment Trial)

RecruitingPhase 2
  • Tufts Medical Center, Boston
  • Beth Israel Deaconess Medical Center, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06317649

Comparing New Treatments for People With Newly Diagnosed Acute Myeloid Leukemia That Has an IDH2 Gene Change (A MyeloMATCH Treatment Trial)

RecruitingPhase 2
  • Tufts Medical Center, Boston
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06672146

Testing New Therapies for Patients With Acute Myeloid Leukemia Who Are Newly Diagnosed and Have Not Yet Started Treatment (A MyeloMATCH Treatment Trial)

RecruitingPhase 2
  • Tufts Medical Center, Boston
  • Beth Israel Deaconess Medical Center, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 to 59 · All sexes · Updated Sep 22, 2026 · NCT05554406

A Multi-Site Break Through Cancer Trial: Phase II Study Investigating Dual Inhibition of BCL2 and Menin in AML MRD Using the Combination of Venetoclax and Revumenib

RecruitingPhase 1/2
  • Dana-Farber Cancer Center, Boston
Ages 12 and older · All sexes · Updated Sep 18, 2026 · NCT06284486

A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations

RecruitingPhase 3
  • Massachusetts General Hospital Cancer Center, Boston
  • Dana-Farber Cancer Institute, Boston
6 Months – 21 Years · All sexes · Updated Sep 17, 2026 · NCT04293562

(Apex) Bezuclastinib in Patients With Advanced Systemic Mastocytosis

RecruitingPhase 2
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT04996875

Ivosidenib and Venetoclax With or Without Azacitidine in Treating Patients With IDH1 Mutated Hematologic Malignancies

RecruitingPhase 1/2
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT03471260

Study of SLS009 (Formerly GFH009) a Potent Highly Selective CDK9 Inhibitor in Patients With Hematologic Malignancies and High-Risk Newly Diagnosed AML

RecruitingPhase 1/2
  • Massachusetts General Hospital, Boston
Ages 12 and older · All sexes · Updated Sep 3, 2026 · NCT04588922

CIML NK Cells With Venetoclax for AML

RecruitingPhase 1
  • Brigham and Women's Hospital, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Aug 28, 2026 · NCT06152809

Assessing PI3K Gamma Inhibition With Azacitidine, Venetoclax and Eganelisib in Patients With Acute Myeloid Leukemia

RecruitingPhase 1
  • Brigham and Women's Hospital, Boston
  • Dana Farber Cancer Institute, Boston
Ages 18 to 90 · All sexes · Updated Aug 26, 2026 · NCT07439211

Eganelisib as Monotherapy and in Combination With Cytarabine in Relapsed/Refractory AML

RecruitingPhase 1
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Aug 25, 2026 · NCT06533761

Venetoclax in Children With Relapsed Acute Myeloid Leukemia (AML)

RecruitingPhase 3
  • Dana-Farber Cancer Institute, Boston
29 Days – 21 Years · All sexes · Updated Aug 24, 2026 · NCT05183035

Safety and Tolerability of Ziftomenib Combinations in Patients With Relapsed/Refractory Acute Myeloid Leukemia

RecruitingPhase 1
  • Beth Israel Deaconess Medical Center, Boston
Ages 18 and older · All sexes · Updated Aug 20, 2026 · NCT06001788

A Vaccine (CMV-MVA Triplex Vaccine) for the Enhancement of CMV-Specific Immunity and the Prevention of CMV Viremia in Patients Undergoing Haploidentical Hematopoietic Stem Cell Transplant

RecruitingPhase 1Healthy volunteers welcome
  • Brigham and Women's Hospital, Boston
Ages 18 to 75 · All sexes · Updated Jul 28, 2026 · NCT07020533

A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

RecruitingObservational study
  • Tufts Medical Center, Boston
  • Beth Israel Deaconess, Boston
  • Dana Farber Cancer Institute, Boston
All ages · All sexes · Updated Jul 6, 2026 · NCT01351545

Ivosidenib as Post-HSCT Maintenance for AML

RecruitingPhase 2
  • Massachusetts General Hospital, Boston
  • Dana Farber Cancer Institute, Boston
Ages 18 to 75 · All sexes · Updated Jun 18, 2026 · NCT06707493

A Phase 1 Trial of CIML NK Cell Infusion for Myeloid Disease Relapse After Hematopoietic Cell Transplantation

RecruitingPhase 1
  • Boston Children's Hospital, Boston
  • Dana Farber Cancer Institute, Boston
Ages 12 and older · All sexes · Updated Jun 17, 2026 · NCT04024761

Preemptive CIML NK Cell Therapy After Hematopoietic Stem Cell Transplantation

RecruitingPhase 1
  • Dana-Farber Cancer Institute, Boston
  • Brigham and Women's Hospital, Boston
Ages 18 and older · All sexes · Updated Jun 17, 2026 · NCT06138587

Study of MGUS, Smoldering Myeloma, Early MDS and CLL to Assess Molecular Events of Progression and Clinical Outcome

RecruitingObservational study
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated May 7, 2026 · NCT02269592

Adoptive T Cell Therapy With DC/AML Fusion Vaccine Plus Decitabine and Venetoclax in AML

RecruitingPhase 1
  • Beth Israel Deaconess Medical Center, Boston
All ages · All sexes · Updated May 5, 2026 · NCT07374029

Study of Oral Administration of LP-118 in Patients With Relapsed or Refractory CLL, SLL, MDS, MDS/MPN, AML, CMML-2, MPN-BP, ALL, MF, NHL, RT, MM or T-PLL.

RecruitingPhase 1
  • Dana Farber Cancer Institute, Boston
Ages 13 and older · All sexes · Updated May 5, 2026 · NCT04771572

A Multi-phase Study of ASTX030 (Azacitidine and Cedazuridine) in Myeloid Neoplasm Alone or in Combination With Venetoclax in AML (AZTOUND Study)

RecruitingPhase 2/3
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Apr 30, 2026 · NCT04256317

BCL2i CLAG-M in R/R Acute Myeloid Leukemia

RecruitingPhase 2
  • Dana-Farber Cancer Institute, Boston
Ages 18 to 80 · All sexes · Updated Apr 1, 2026 · NCT06660368

Revumenib in Combination With 7+3 + Midostaurin in AML

RecruitingPhase 1
  • Dana-Farber Cancer Institute, Boston
Ages 18 to 75 · All sexes · Updated Mar 25, 2026 · NCT06313437

A Phase 1/2 Study of Enzomenib (DSP-5336) in Patients With Acute Leukemia (Horizen-1)

RecruitingPhase 1/2
  • Massachusetts General Hospital, Boston
Ages 12 and older · All sexes · Updated Mar 24, 2026 · NCT04988555

Ziftomenib Maintenance Post Allo-HCT

RecruitingPhase 1
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated Mar 19, 2026 · NCT06440135

A Study of CBX-250 in Participants With Relapsed or Refractory Myeloid Leukemias

RecruitingPhase 1
  • Dana Farber Cancer Institute, Boston
Ages 12 and older · All sexes · Updated Mar 16, 2026 · NCT06994676

A Study to Investigate the Safety and Tolerability of Ziftomenib in Combination With Venetoclax/Azacitidine, Venetoclax, 7+3, or 7+3+Quizartinib in Patients With AML

RecruitingPhase 1
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated Mar 13, 2026 · NCT05735184

CMV-MVA Triplex Vaccination in HLA-Matched Related Stem Cell Donors for the Prevention of CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplant

RecruitingPhase 2Healthy volunteers welcome
  • DFCI/BWH Brigham and Women's Hospital, Boston
Ages 18 to 75 · All sexes · Updated Mar 10, 2026 · NCT06059391

A Phase 1 Study of STX-0712 in Patients With Advanced Hematological Malignancies (CMML and AML)

RecruitingPhase 1
  • DFCI, Boston
Ages 18 and older · All sexes · Updated Feb 9, 2026 · NCT06950034

A Multi-Site Break Through Cancer Trial: Targeting Measurable Residual Disease in Patients With Acute Myeloid Leukemia: A Phase 1/2 Study of Tagraxofusp, Azacitidine, and Venetoclax

RecruitingPhase 1/2
  • Brigham and Women's Hospital, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Feb 5, 2026 · NCT07148180

Novel Digital Application for Patients With Acute Leukemia

Recruiting
  • Massachusetts General Hospital (MGH), Boston
Ages 18 to 120 · All sexes · Updated Nov 10, 2025 · NCT06472128

IS-free Treg HaploHCT

RecruitingPhase 1
  • Dana Farber Cancer Institute, Boston
Ages 18 to 75 · All sexes · Updated Oct 20, 2025 · NCT04678401

Specialty Compared to Oncology Delivered Palliative Care for Patients With Acute Myeloid Leukemia

RecruitingHealthy volunteers welcome
  • Massachusetts General Hospital, Boston
  • Dana-Farber Cancer Institute, Boston
Ages 18 to 120 · All sexes · Updated Jul 25, 2025 · NCT05237258

BXCL701 Phase 1 R/R Acute Myeloid Leukemia or Myelodysplastic Syndrome

RecruitingPhase 1
  • Dana Farber Cancer Institute, Boston
Ages 18 and older · All sexes · Updated Jul 18, 2025 · NCT05703542

Study of REM-422 in Patients With AML or Higher Risk MDS

RecruitingPhase 1
  • Massachusetts General Hospital, Boston
Ages 18 and older · All sexes · Updated Apr 23, 2025 · NCT06297941

About Acute Myeloid Leukemia

Acute Myeloid Leukemia (AML) is a cancer of the white blood cells. AML usually gets worse quickly if it is not treated. Read more.

More about Acute Myeloid Leukemia on MedlinePlus

Acute Myeloid Leukemia trials in other cities

Other studies in Boston

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.