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Obesity clinical trials in New York City, NY

40 studies for Obesity are looking for participants at sites in and around New York City (within about 30 miles). Open a study to see who can join and how to contact the study team.

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The RESET System Pivotal Clinical Trial (Protocol Revision H)

Recruiting
  • Weill Cornell Medicine, New York
Ages 22 to 65 · All sexes · Updated Oct 5, 2026 · NCT04101669

Comparing the Efficacy and Safety of the EndoZip System and Apollo ESG in Obese Patients

Recruiting
  • Weill Cornell -1300 York Avenue, New York
  • Lenox Hill Hospital | Northwell Health, New York
Ages 21 to 65 · All sexes · Updated Oct 1, 2026 · NCT07090005

A Study to Learn About the Study Medicine Called Berobenatide (PF-08653944) in People With Overweight or Obesity

RecruitingPhase 3
  • Weill Cornell Medicine - Comprehensive Weight Control Center, New York
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07595549

Study to Assess the Effect and Safety of ALV-100 on Maintenance of Weight Loss

RecruitingPhase 2
  • ALSA Research-Manhattan, New York
Ages 18 to 75 · All sexes · Updated Sep 28, 2026 · NCT07837973

AMAZE 9: A Research Study Investigating How Well Zenagamtide Tablets Help People With Excess Body Weight Lose Weight

RecruitingPhase 3
  • Comprehensive Weight Ctrl Prog, New York
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07720271

Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight

RecruitingPhase 3
  • New York Gastroenterology Associates, New York
Ages 18 to 70 · All sexes · Updated Sep 24, 2026 · NCT06937099

AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight

RecruitingPhase 3
  • New York Gastroenterology Associates, New York
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT07339423

Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study

RecruitingPhase 3
  • Icahn School of Medicine at Mount Sinai, New York
  • New York Gastroenterology Associates, New York
Ages 18 to 70 · All sexes · Updated Sep 24, 2026 · NCT06937086

A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin

RecruitingPhase 3
  • NYU Langone Health, New York
  • Weill Cornell Medical College, New York
  • IMA Clinical Research Manhattan, New York
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07392190

Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

RecruitingPhase 3
  • Icahn School of Medicine at Mount Sinai, New York
Ages 18 to 99 · All sexes · Updated Sep 16, 2026 · NCT07037459

Graded Insulin Suppression Test P&F

RecruitingPhase 1Healthy volunteers welcome
  • Columbia University Irving Medical Center, New York
Ages 18 to 65 · All sexes · Updated Sep 8, 2026 · NCT06592261

Efficacy and Safety of Ribupatide Administered Once Weekly in Participants Living With Obesity or Overweight and Diabetes

RecruitingPhase 3
  • Kailera Clinical Site, New York
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT07284901

Alpelisib Challenge Test (ACT)

RecruitingPhase 1Healthy volunteers welcome
  • Columbia University Irving Medical Center, New York
Ages 18 to 70 · All sexes · Updated Sep 3, 2026 · NCT07778524

Taxi ROADmAP (Realizing Optimization Around Diet And Physical Activity)

RecruitingPhase 2Healthy volunteers welcome
  • Mexican Consulate's Ventanilla de Salud (VDS), New York
Ages 21 and older · All sexes · Updated Sep 2, 2026 · NCT05770570

Efficacy, Safety and Tolerability of Switching From Glucagon-like Peptide-1 Receptor Agonists (GLP-1RA) to Maridebart Cafraglutide in Adults With Obesity or Overweight (MARITIME-SWITCH)

RecruitingPhase 3
  • Icahn School of Medicine at Mount Sinai, New York
Ages 18 to 99 · All sexes · Updated Aug 27, 2026 · NCT07575399

Incretin Therapies in Obesity-related HFpEF

RecruitingPhase 4
  • Columbia University Irving Medical Center (CUIMC) / NewYork Presbyterian Hospital (NYP), New York
Ages 40 and older · All sexes · Updated Aug 24, 2026 · NCT07554638

Human Models of Selective Insulin Resistance: Alpelisib, Part I

RecruitingPhase 1Healthy volunteers welcome
  • Columbia University Irving Medical Center, New York
Ages 18 to 70 · All sexes · Updated Aug 24, 2026 · NCT06354088

A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity

RecruitingPhase 3
  • NYU Langone Med Assoc Chelsea, New York
  • NYU Langone Orthopedic Center, New York
  • Mount Sinai Hosp at NYC, New York
  • and 1 more
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07567001

AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

RecruitingPhase 3
  • NYU Langone Orthopedic Center, New York
  • Hospital For Special Surgery, New York
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT07509307

Atomoxetine in Melanocortin Obesity Syndrome

RecruitingPhase 2
  • Mount Sinai Hospital, New York
Ages 6 and older · All sexes · Updated Aug 7, 2026 · NCT06899178

Tirzepatide's Role in Postmenopausal HR+ Breast Cancer Survivors

RecruitingPhase 4
  • Weill Cornell Medicine, New York
Ages 18 and older · Women · Updated Jul 22, 2026 · NCT07257484

Effect of Insulin Lowering on Lipogenesis

RecruitingPhase 1
  • Columbia University Irving Medical Center, New York
Ages 18 to 65 · All sexes · Updated Jul 6, 2026 · NCT07403604

A Study to Investigate Why Overweight People Regain Weight After Losing Weight in a Behavioral Weight Loss Program

Recruiting
  • Columbia University Irving Medical Center, New York
Ages 25 to 59 · All sexes · Updated Jun 12, 2026 · NCT05748158

Weight Loss Study: Genetics and Response to Naltrexone/Bupropion

RecruitingPhase 4
  • Columbia University Medical Center, New York
Ages 18 to 65 · All sexes · Updated Jun 10, 2026 · NCT05919797

Impact of Yo-Yo Sleep on Cardiometabolic Health

RecruitingHealthy volunteers welcome
  • Columbia University Irving Medical Center, New York
Ages 18 to 49 · All sexes · Updated May 18, 2026 · NCT05880758

Endoscopic Bariatric Therapies (EBTs): A Retrospective and Prospective Multicenter Registry

RecruitingObservational study
  • Weill Cornell Medicine, New York
Ages 18 to 89 · All sexes · Updated Apr 23, 2026 · NCT04494048

A Study to Evaluate Tradipitant on Treating Nausea and Vomiting Induced by GLP-1R Agonist Use

RecruitingPhase 3Healthy volunteers welcome
  • Vanda Investigational Site, New York
Ages 18 to 65 · All sexes · Updated Apr 20, 2026 · NCT07446439

Family COMIDA (Consumo de Opciones Más Ideales De Alimentos) (Eating More Ideal Food Options)

RecruitingHealthy volunteers welcome
  • Memorial Sloan Kettering Cancer Center (All Protocol Activities), New York
Ages 18 and older · All sexes · Updated Apr 15, 2026 · NCT07144800

A Study of a Weight Loss Intervention in People With Endometrial Cancer

RecruitingEarly phase 1
  • Memorial Sloan Kettering Cancer Center, New York
Ages 18 and older · Women · Updated Apr 13, 2026 · NCT06751589

Reducing Obesity Using Social Ties Program

Recruiting
  • Weill Cornell Medicine, New York
Ages 18 and older · All sexes · Updated Apr 1, 2026 · NCT06335810

CHIME: Comparing Health Interventions for Maternal Equity

RecruitingHealthy volunteers welcome
  • Columbia University Medical Center, New York
  • NYU Langone Health, New York
Ages 18 and older · Women · Updated Mar 5, 2026 · NCT06724172

Time Restricted Eating for WeIght LoSs MainTenance-2

Recruiting
  • NYU Langone Health, New York
Ages 25 to 65 · All sexes · Updated Dec 26, 2025 · NCT07190170

High Fructose Diet, the Gut Microbiome, and Metabolic Health

RecruitingHealthy volunteers welcome
  • Mount Sinai Morningside, New York
Ages 25 to 45 · All sexes · Updated Dec 17, 2025 · NCT06329544

Study to Investigate Genetic Causes of Severe Early Childhood Onset Obesity.

RecruitingObservational study
  • Columbia University Medical Center, New York
Up to age 80 · All sexes · Updated Oct 21, 2025 · NCT01998750

A Bilingual Virtually-based Intervention (PEDALL) for the Prevention of Weight Gain in Childhood ALL Patients Considering Key Genetic and Sociodemographic Risk Factors

Recruiting
  • Columbia University Medical Center, New York
Ages 5 to 21 · All sexes · Updated Oct 7, 2025 · NCT05963971

Effects of Ultra Processed Food on Intestinal Energy Harvest

Recruiting
  • Columbia University Irving Medical Center, New York
Ages 25 and older · All sexes · Updated Oct 3, 2025 · NCT06853288

Chronic Widespread Pain After Rapid Weight Loss in Non-Hispanic Black and Hispanic/Latino/a/x Adults

RecruitingObservational study
  • NYU Steinhardt Arthur J. Nelson Laboratory, New York
  • New York City Health + Hospitals/Bellevue Hospital, New York
  • NYU CTSI Clinical Research Center, New York
Ages 18 to 75 · All sexes · Updated Jan 28, 2025 · NCT06795386

About Obesity

Read about the causes of obesity and find out what you can do to decrease your risk of its associated health issues.

More about Obesity on MedlinePlus

Obesity trials in other cities

Other studies in New York City

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.