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Cardiovascular Disease clinical trials in Chicago, IL

21 studies for Cardiovascular Disease are looking for participants at sites in and around Chicago (within about 30 miles). Open a study to see who can join and how to contact the study team.

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ELEVATE-HFpEF Clinical Study

Recruiting
  • The University of Chicago Medical Center, Chicago
Ages 40 and older · All sexes · Updated Oct 2, 2026 · NCT06678841

EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease

RecruitingPhase 3
  • Cedar Crosse Research Center, Chicago
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT07064473

Product Surveillance Registry

RecruitingObservational study
  • Chicago, Chicago
All ages · All sexes · Updated Sep 18, 2026 · NCT01524276

Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease

RecruitingPhase 3
  • Clinical Trial Site, Chicago
  • Clinical Trial Site, Chicago
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT07181109

Zenith® Fenestrated+ Clinical Study

Recruiting
  • Northwestern Memorial Hospital, Chicago
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT04875429

Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

Recruiting
  • Northwestern Memorial Hospital, Chicago
  • Rush University Medical Center, Chicago
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT03242642

Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure

Recruiting
  • Advocate Christ Medical Center, Chicago
  • Northwestern University, Chicago
  • University of Chicago, Chicago
Ages 18 to 100 · All sexes · Updated Sep 9, 2026 · NCT06310031

An Open Label Extension (OLE) Study (Following Completion of CTQJ230A12301) to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230)

RecruitingPhase 3
  • Rush University Medical Center, Chicago
Ages 18 to 100 · All sexes · Updated Sep 4, 2026 · NCT07517263

A Study of Mosliciguat in Combination With Inhaled Treprostinil in PH-ILD

RecruitingPhase 2
  • Clinical Research Site, Chicago
Ages 18 to 85 · All sexes · Updated Sep 2, 2026 · NCT07333183

Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

RecruitingPhase 4Healthy volunteers welcome
  • Northwestern University, Chicago
  • University of Illinois at Chicago, Chicago
  • Chicago VA Medical Center/Jesse Brown VA, Chicago
  • and 2 more
Ages 75 and older · All sexes · Updated Sep 1, 2026 · NCT04262206

A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event

RecruitingPhase 3
  • Research Site, Chicago
  • Research Site, Chicago
  • Research Site, Chicago
Ages 18 and older · All sexes · Updated Aug 24, 2026 · NCT07000357

NOrthwestern Tempus AI-enaBLed Electrocardiography (NOTABLE) Trial

RecruitingHealthy volunteers welcome
  • Northwestern University, Chicago
Ages 40 and older · All sexes · Updated Aug 20, 2026 · NCT06511505

Role of Adiposomes in Endothelial Dysfunction

Recruiting
  • University of Illinois at Chicago, Chicago
Ages 18 to 50 · All sexes · Updated Aug 17, 2026 · NCT05199454

Study of the Progression of Chronic Cardiovascular Conditions

RecruitingObservational study
  • Prolaio, Chicago
Ages 18 and older · All sexes · Updated Aug 12, 2026 · NCT07420907

The TRICURE EFS Study

Recruiting
  • Northwestern, Chicago
Ages 18 and older · All sexes · Updated Jul 23, 2026 · NCT06506942

Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure

Recruiting
  • University of Chicago, Chicago
Ages 18 and older · All sexes · Updated Jun 10, 2026 · NCT06526195

Aspirin and Preeclampsia

RecruitingPhase 4
  • University of Chicago Hospital, Chicago
Ages 18 to 45 · Women · Updated May 4, 2026 · NCT04479072

Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease

RecruitingPhase 3
  • Northwestern University Feinberg School of Medicine, Chicago
Ages 18 to 75 · All sexes · Updated Mar 24, 2026 · NCT06217302

Biobank Cardiac Surgery

RecruitingObservational study
  • The University of Chicago, Hyde Park · 5 mi away
All ages · All sexes · Updated Dec 19, 2025 · NCT06747806

PARTNER 3 Trial - Aortic Valve-in-Valve

Recruiting
  • Northwestern University Hospital, Chicago
  • Rush University Medical Center, Chicago
All ages · All sexes · Updated May 10, 2024 · NCT03003299

Cardiovascular Disease trials in other cities

Other studies in Chicago

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.