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Acute Myeloid Leukemia clinical trials in Philadelphia, PA

34 studies for Acute Myeloid Leukemia are looking for participants at sites in and around Philadelphia (within about 30 miles). Open a study to see who can join and how to contact the study team.

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Comparing Different Treatment Lengths for Venetoclax in Older People With Newly Diagnosed Acute Myeloid Leukemia (A MyeloMATCH Treatment Trial)

RecruitingPhase 2
  • Thomas Jefferson University Hospital, Philadelphia
Ages 60 and older · All sexes · Updated Oct 5, 2026 · NCT07437950

MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

RecruitingPhase 2
  • University of Pennsylvania/Abramson Cancer Center, Philadelphia
  • Thomas Jefferson University Hospital, Philadelphia
Ages 18 and older · All sexes · Updated Oct 5, 2026 · NCT05564390

Assessment of Geriatric Evaluations Impact on New AML Guidance

RecruitingObservational study
  • Abramson Cancer Center at University of Pennsylvania, Philadelphia
Ages 50 and older · All sexes · Updated Oct 2, 2026 · NCT05909501

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • Reading Hospital McGlinn Cancer Institute at Phoenixville, Phoenixville · 22 mi away
Ages 40 to 75 · All sexes · Updated Oct 2, 2026 · NCT05334069

Pharmacokinetic Study of Venetoclax Tablets Crushed and Dissolved Into a Solution

RecruitingObservational study
  • Children's Hospital of Philadelphia, Philadelphia
Ages 0 to 38 · All sexes · Updated Oct 1, 2026 · NCT06131801

A Study of Bleximenib, Venetoclax and Azacitidine For Treatment of Participants With Newly Diagnosed Acute Myeloid Leukemia (AML)

RecruitingPhase 3
  • Thomas Jefferson University, Philadelphia
  • Fox Chase Cancer Center, Philadelphia
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06852222

Comparing New Treatments for People With Newly Diagnosed Acute Myeloid Leukemia That Has an IDH2 Gene Change (A MyeloMATCH Treatment Trial)

RecruitingPhase 2
  • Thomas Jefferson University Hospital, Philadelphia
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06672146

Testing New Therapies for Patients With Acute Myeloid Leukemia Who Are Newly Diagnosed and Have Not Yet Started Treatment (A MyeloMATCH Treatment Trial)

RecruitingPhase 2
  • University of Pennsylvania/Abramson Cancer Center, Philadelphia
  • Thomas Jefferson University Hospital, Philadelphia
Ages 18 to 59 · All sexes · Updated Sep 22, 2026 · NCT05554406

Venetoclax and HMA Treatment of Older and Unfit Adults With FLT3 Mutated Acute Myeloid Leukemia (AML) (A MyeloMATCH Treatment Trial)

RecruitingPhase 2
  • University of Pennsylvania/Abramson Cancer Center, Philadelphia
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06317649

A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations

RecruitingPhase 3
  • Children's Hospital of Philadelphia, Philadelphia
  • Saint Christopher's Hospital for Children, Philadelphia
  • Alfred I duPont Hospital for Children, Wilmington · 25 mi away
6 Months – 21 Years · All sexes · Updated Sep 17, 2026 · NCT04293562

A Study of Revumenib in R/R Leukemias Including Those With an MLL/KMT2A Gene Rearrangement or NPM1 Mutation

RecruitingPhase 1/2
  • University of Pennsylvania, Philadelphia
30 Days · All sexes · Updated Sep 16, 2026 · NCT04065399

Phase 1 Study of AUTX-703 in Relapsed/Refractory AML and MDS

RecruitingPhase 1
  • UPENN Perelman Center for Advanced Medicine, Philadelphia
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT06846606

Xylitol Dental Wipes for the Reduction of Bloodstream Infection Risk in Children With Acute Myeloid Leukemia

RecruitingPhase 3
  • Children's Hospital of Philadelphia, Philadelphia
  • Alfred I duPont Hospital for Children, Wilmington · 25 mi away
Ages 1 to 25 · All sexes · Updated Sep 4, 2026 · NCT07022678

The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study

RecruitingPhase 1/2
  • Children's Hospital of Philadelphia, Philadelphia
  • Saint Christopher's Hospital for Children, Philadelphia
  • Alfred I duPont Hospital for Children, Wilmington · 25 mi away
Up to age 22 · All sexes · Updated Aug 25, 2026 · NCT04726241

Venetoclax in Children With Relapsed Acute Myeloid Leukemia (AML)

RecruitingPhase 3
  • Children's Hospital of Philadelphia, Philadelphia
  • Nemours Alfred I. Dupont Hospital for Children, Wilmington · 25 mi away
29 Days – 21 Years · All sexes · Updated Aug 24, 2026 · NCT05183035

Studies to Assess Ziftomenib in Combination With Ven+Aza or 7+3 in Patients With Untreated NPM1-m or KMT2A-r AML

RecruitingPhase 3
  • University of Pennsylvania, Philadelphia
Ages 18 and older · All sexes · Updated Aug 20, 2026 · NCT07007312

L-Annamycin for Injection in Combination With Cytarabine Injection as Second Line Therapy for Remission Induction in Adult Subjects With Refractory/Relapsed AML

RecruitingPhase 2/3
  • University of Pennsylvania, Philadelphia
Ages 18 to 80 · All sexes · Updated Aug 5, 2026 · NCT06788756

Study of Revumenib, Azacitidine, and Venetoclax in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia

RecruitingPhase 1
  • Children's Hospital of Philadelphia, Philadelphia
Ages 1 to 30 · All sexes · Updated Aug 3, 2026 · NCT06177067

Tagraxofusp and Azacitidine With Venetoclax in Newly Diagnosed Secondary AML After Hypomethylating Agents

RecruitingPhase 2
  • Penn Medicine Abramson Cancer Center, Philadelphia
Ages 18 and older · All sexes · Updated Jul 10, 2026 · NCT05442216

CD33KO-HSPC Infusion Followed by CART-33 Infusion(s) for Refractory/Relapsed AML

RecruitingPhase 1
  • University of Pennsylvania, Philadelphia
Ages 18 and older · All sexes · Updated Jul 9, 2026 · NCT05945849

CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post TCRαβ/CD19 Depleted HSCT

Recruiting
  • Children's Hospital of Philadelphia, Philadelphia
Up to age 25 · All sexes · Updated Jul 8, 2026 · NCT03810196

CART123 Cells With or Without Ruxolitinib in Relapsed/Refractory Acute Myeloid Leukemia

RecruitingPhase 1
  • Children's Hospital of Philadelphia, Philadelphia
Ages 0 to 29 · All sexes · Updated Jul 7, 2026 · NCT07464951

A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

RecruitingObservational study
  • Children's Hospital of Philadelphia, Philadelphia
  • Nemours - Alfred I. duPont Hospital for Children, Brandywine · 21 mi away
All ages · All sexes · Updated Jul 6, 2026 · NCT01351545

Study to Evaluate CCS1477 (Inobrodib) in Haematological Malignancies

RecruitingPhase 1/2
  • Penn Medicine - Abramson Cancer Center Perelman, Philadelphia
Ages 18 and older · All sexes · Updated Jun 24, 2026 · NCT04068597

SNDX-5613 and Gilteritinib for the Treatment of Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia and Concurrent MLL-Rearrangement or NPM1 Mutation

RecruitingPhase 1
  • University of Pennsylvania, Philadelphia
Ages 18 and older · All sexes · Updated May 14, 2026 · NCT06222580

Massage Impact on Sleep in Pediatric Oncology

Recruiting
  • Children's Hospital of Philadelphia, Philadelphia
Ages 12 to 21 · All sexes · Updated Apr 15, 2026 · NCT06892158

A Phase 1/2 Study of Enzomenib (DSP-5336) in Patients With Acute Leukemia (Horizen-1)

RecruitingPhase 1/2
  • Sidney Kimmel Comprehensive Cancer Center, Philadelphia
Ages 12 and older · All sexes · Updated Mar 24, 2026 · NCT04988555

Phase IB/II of CPX-351 for Relapse Prevention in AML

RecruitingPhase 1/2
  • University of Pennsylvania, Philadelphia
Ages 18 and older · All sexes · Updated Mar 23, 2026 · NCT04990102

A Study of CBX-250 in Participants With Relapsed or Refractory Myeloid Leukemias

RecruitingPhase 1
  • Thomas Jefferson University Hospital, Philadelphia
Ages 12 and older · All sexes · Updated Mar 16, 2026 · NCT06994676

A Study to Investigate the Safety and Tolerability of Ziftomenib in Combination With Venetoclax/Azacitidine, Venetoclax, 7+3, or 7+3+Quizartinib in Patients With AML

RecruitingPhase 1
  • Hospital of the University of Pennsylvania, Philadelphia
Ages 18 and older · All sexes · Updated Mar 13, 2026 · NCT05735184

Tazemetostat and Palbociclib With CPX-351for R/R AML

RecruitingPhase 1
  • Thomas Jefferson University Hospital, Philadelphia
Ages 18 and older · All sexes · Updated Mar 12, 2026 · NCT05627232

Home Blood Transfusions

Recruiting
  • Thomas Jefferson University Hospital, Philadelphia
Ages 18 and older · All sexes · Updated Dec 16, 2025 · NCT07121140

Specialty Compared to Oncology Delivered Palliative Care for Patients With Acute Myeloid Leukemia

RecruitingHealthy volunteers welcome
  • University of Pennsylvania, Philadelphia
Ages 18 to 120 · All sexes · Updated Jul 25, 2025 · NCT05237258

About Acute Myeloid Leukemia

Acute Myeloid Leukemia (AML) is a cancer of the white blood cells. AML usually gets worse quickly if it is not treated. Read more.

More about Acute Myeloid Leukemia on MedlinePlus

Acute Myeloid Leukemia trials in other cities

Other studies in Philadelphia

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.