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Cancer (all types) clinical trials in Chicago, IL
51 studies for Cancer (all types) are looking for participants at sites in and around Chicago (within about 30 miles). Open a study to see who can join and how to contact the study team.
Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →
A Study to Evaluate Adverse Events, Change in Disease Activity, Tolerability, and How Intravenous ABBV-438 Moves Through the Body in Adult Participants With Multiple Myeloma (MM)
RecruitingPhase 1
- University of Chicago Medical Center /ID# 278863, Chicago
uTRACT Jelmyto Registry: A Registry of Patients With Upper Tract Urothelial Cancer (UTUC) Treated With Jelmyto
RecruitingObservational study
- Northwestern University, Chicago
A Phase 3 Study of Ersodetug in Patients With Tumor Hyperinsulinism
RecruitingPhase 3
- Investigative Site, Chicago
A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)
RecruitingPhase 3
- University of Illinois Chicago, Chicago
A Study of Zolbetuximab Together With Pembrolizumab and Chemotherapy in Adults With Gastric Cancer
RecruitingPhase 3
- Northwestern Memorial Hospital, Chicago
A Study to Evaluate Adverse Events and Change in Disease Activity of Intravenous ABBV-706 Versus Standard of Care in Adult Participants With Relapsed/Refractory Small Cell Lung Cancer
RecruitingPhase 3
- University of Chicago Medical Center /ID# 280149, Chicago
TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer
RecruitingPhase 2
- Cancer Treatment Centers of America-Chicago, Chicago
Long-Term Follow-up Protocol for Participants Treated With Gene-Modified T Cells
RecruitingPhase 2/3
- Northwestern Memorial Hospital, Chicago
- University Of Chicago Medical Center, Chicago
RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses
RecruitingPhase 2
- Rush University Medical Center, Chicago
- University of Chicago Medical Center, Chicago
Evaluating the Communication Between Patients and Providers in Cancer Clinics
Recruiting
- Northwestern Memorial Hospital, Chicago
The ECOG-ACRIN SUPPORT Trial: Multilevel Intervention to Improve Diverse Enrollment in Cancer Clinical Trials
Recruiting
- Advocate Illinois Masonic Medical Center, Chicago
A Clinical Study of MK-8294 in Participants With Advanced Solid Tumors (MK-8294-001)
RecruitingPhase 1
- Northwestern University ( Site 0101), Chicago
A Phase 1/1b Study of IAM1363 in HER2 Cancers
RecruitingPhase 1
- University of Chicago, Chicago
A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer
RecruitingPhase 3
- University of Illinois at Chicago, Chicago
- University of Chicago Hospital, Chicago
Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation
RecruitingPhase 3
- Insight Research Institute, Chicago
A Longitudinal Multi-Omic Biomarker Profiling Study of Patients With Head & Neck Squamous Cell Carcinoma (HNSCC)
RecruitingObservational study
- Northwestern University Feinberg School of Medicine, Chicago
Ovarian Tissue Cryopreservation in Post Pubertal (OTC-Post Pubertal)
RecruitingObservational study
- Ann &Robert H Lurie Children's Hospital, Chicago
Ovarian Tissue Cryopreservation in Pre-Pubertal (OTC-Pre Pubertal)
RecruitingObservational study
- Ann & Robert H Lurie Childrens Hospital, Chicago
Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.
RecruitingPhase 3
- Northwestern University, Chicago
Project: Every Child for Younger Patients With Cancer
RecruitingObservational study
- Lurie Children's Hospital-Chicago, Chicago
- Northwestern University, Chicago
- University of Illinois, Chicago
- and 1 more
Abatacept in Immune Checkpoint Inhibitor Myocarditis
RecruitingPhase 3
- University of Chicago, Chicago
Two Part Study of Nenocorilant Combined With Nivolumab in Patients With Advanced Solid Malignancies
RecruitingPhase 1/2
- Site 05, Chicago
A Study of Tulmimetostat DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and Lymphomas
RecruitingPhase 1/2
- University of Chicago Medical Center, Chicago
Tempus Open Link for Individual Voices in Innovative Analytics Registry: Platform Protocol for Multimodal Real-World Evidence in Cancer
RecruitingObservational studyHealthy volunteers welcome
- Tempus AI, Chicago
International Rare Brain Tumor Registry
RecruitingObservational study
- Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago
A Master Protocol (LY900023) That Includes Several Clinical Trials of Drugs for Children and Young Adults With Cancer
RecruitingPhase 2
- Ann & Robert H Lurie Children's Hospital of Chicago, Chicago
Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer
RecruitingPhase 3
- John H Stroger Jr Hospital of Cook County, Chicago
- University of Illinois, Chicago
- University of Chicago Comprehensive Cancer Center, Chicago
- and 1 more
Illuminate: A Clinical Study Evaluating CAR T Immune Cell Therapy (BCB-276) for Patients With Diffuse Intrinsic Pontine Glioma (DIPG).
RecruitingPhase 2
- Lurie Children's Hospital, Chicago
Study of mRNA-4359 Administered Alone and in Combination With Immune Checkpoint Blockade in Participants With Advanced Solid Tumors
RecruitingPhase 1/2
- The University of Chicago Medicine, Chicago
A Study to Assess Adverse Events and Change in Disease Activity in Adult Participants Receiving Intravenously Infused Telisotuzumab Adizutecan Alone or With Standard of Care in Participants With Post Adjuvant Circulating Tumor DNA Positive Colorectal Cancer and No Radiographic Evidence of Disease
RecruitingPhase 2
- University of Chicago Medical Center /ID# 274742, Chicago
Sun Exposure and Activities After Skin Cancer: Optimization of mHealth Interventions
Recruiting
- Northwestern University, Chicago
Mobile Health Intervention to Support Oral Chemotherapy Adherence in Adolescents and Young Adults With Leukemia
Recruiting
- Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago
Molecular Genetics Studies of Cancer Patients and Their Relatives
RecruitingObservational studyHealthy volunteers welcome
- John H Stroger Jr Hospital of Cook County, Chicago
- Rush University Medical Center, Chicago
Advancing Cancer Control Engaged Research Through Transformative Solutions (ACCERT) Social Determinants of Health (SDoH) Navigation Program
RecruitingHealthy volunteers welcome
- Northwestern University, Chicago
Childhood Cancer Survivor Study
RecruitingObservational studyHealthy volunteers welcome
- Ana & Robert H. Lurie Children's Hospital of Chicago, Chicago
- University of Chicago, Chicago
Lactulose to Improve Gut Health in Cancer Patients Receiving Immunotherapy
RecruitingPhase 1/2
- University of Chicago Medicine Comprehensive Cancer Center, Chicago
CT-95 in Advanced Cancers Associated With Mesothelin Expression
RecruitingPhase 1
- Context Investigational Site, Chicago
A Study to Evaluate the Safety, Tolerability, and Efficacy of MORAb-202 (Herein Referred to as Farletuzumab Ecteribulin), a Folate Receptor Alpha (FRα)-Targeting Antibody-drug Conjugate (ADC) in Participants With Selected Tumor Types
RecruitingPhase 1/2
- Northwestern Memorial Hospital, Chicago
Post Mortem Tissue Donation of Pediatric Tumor Tissues and Cells
RecruitingObservational study
- Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago
My Wellbeing Guide: A Novel Tool for Managing Stress and Improving Quality of Life
Recruiting
- Northwestern University, Chicago
A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements
RecruitingPhase 1/2
- University of Chicago, Chicago
ACTengine® IMA203/IMA203CD8 as Monotherapy or in Combination With Nivolumab in Recurrent and/or Refractory Solid Tumors
RecruitingPhase 1/2
- University of Chicago Medical Center, Chicago
I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer
RecruitingPhase 2
- University of Chicago, Chicago
CA-4948-101: Open-Label, Dose Escalation and Expansion Trial of Emavusertib (CA-4948) in Relapsed or Refractory Primary Central Nervous System Lymphoma (R/R PCNSL)
RecruitingPhase 1/2
- Northwestern Memorial Hospital, Chicago
Evaluating Personalized Therapeutics Clinic (PTC) on Drug-Drug Interactions and Drug-Gene Interactions
Recruiting
- University of Chicago Medicine, Chicago
Safety, PK, and Preliminary Efficacy of MBRC-101 in Advanced Refractory Solid Tumors
RecruitingPhase 1/2
- University of Chicago Medical Center, Chicago
SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
RecruitingObservational study
- Massive Bio SYNERGY-AI site, Chicago
Phase 1 Study Evaluating BA3182 in Patients With Advanced Adenocarcinoma.
RecruitingPhase 1
- Northwestern University, Chicago
- University of Illinois, Chicago
A Study of NX-1607 in Adults With Advanced Malignancies
RecruitingPhase 1
- University of Chicago, Chicago
Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma
Recruiting
- Advocate Illinois Masonic Medical Center, Chicago
DREAM: Double Lung Transplant REgistry Aimed for Lung-limited Malignancies
RecruitingObservational study
- Thoracic Surgery, Canning Thoracic Institute (Northwestern Memorial Hospital), Chicago
About Cancer (all types)
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Cancer (all types) trials in other cities
- Houston, TX121 studies
- New York City, NY110 studies
- Boston, MA86 studies
- Los Angeles, CA73 studies
- Nashville, TN65 studies
- Philadelphia, PA59 studies
- Durham, NC58 studies
- Washington, DC58 studies
- Seattle, WA49 studies
- Atlanta, GA49 studies
- Arlington, VA48 studies
- St. Louis, MO46 studies
Other studies in Chicago
- Non-Small Cell Lung Cancer61 studies
- Breast Cancer58 studies
- Metastatic Cancer45 studies
- Prostate Cancer45 studies
- Obesity41 studies
- Lung Cancer41 studies
- Ovarian Cancer36 studies
- Stroke34 studies
- Colorectal Cancer33 studies
- Heart Failure31 studies
- Overweight28 studies
- Head and Neck Squamous Cell Carcinoma26 studies
From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.