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Ovarian Cancer clinical trials in Chicago, IL

36 studies for Ovarian Cancer are looking for participants at sites in and around Chicago (within about 30 miles). Open a study to see who can join and how to contact the study team.

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Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

RecruitingPhase 2
  • Mount Sinai Hospital Medical Center, Chicago
  • Northwestern University, Chicago
  • John H Stroger Jr Hospital of Cook County, Chicago
  • and 3 more
All ages · All sexes · Updated Oct 2, 2026 · NCT05564377

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

RecruitingPhase 1
  • University of Chicago Hospital, Chicago
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06465069

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 2
  • University of Illinois Cancer Center, Chicago
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06172478

A Study to Assess Adverse Events, Change in Disease Activity and How Intravenous (IV) ABBV901 Moves Through the Body Alone or in Combination With Other Anticancer Drugs in Adult Participants With Ovarian Cancer

RecruitingPhase 1
  • University of Chicago Medical Center /ID# 278295, Chicago
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT07278336

A Study to Assess Anti-Tumor Activity of Intravenously (IV) Infused Carboplatin With Mirvetuximab Soravtansine in Participants With Newly Diagnosed Folate Receptor Alpha (FRα)Expressing Advanced-Stage Serous Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer.

RecruitingPhase 2
  • Rush Md Anderson Cancer Center /ID# 274926, Chicago
  • University of Chicago Medical Center /ID# 274796, Chicago
Ages 18 and older · Women · Updated Sep 29, 2026 · NCT06890338

Leveraging Methylated DNA Markers (MDMs) in the Detection of Endometrial Cancer, Ovarian Cancer, and Cervical Cancer

RecruitingObservational study
  • University of Chicago, Chicago
Ages 18 and older · Women · Updated Sep 29, 2026 · NCT05051722

A Study to Find Out How Safe REGN5668 is and How Well it Works In Adult Women When Given With Either Cemiplimab, or Cemiplimab + Fianlimab, or Ubamatamab

RecruitingPhase 1/2
  • Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago
  • University of Chicago Medical Center, Chicago
Ages 18 and older · Women · Updated Sep 24, 2026 · NCT04590326

A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer

RecruitingPhase 3
  • Northwestern Memorial Hospital, Chicago
  • Rush University Medical Center, Chicago
  • The University of Chicago Medicine, Chicago
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07213804

Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors

RecruitingPhase 1
  • Northwestern University Feinberg School of Medicine, Chicago
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT05983432

Study to Evaluate INCB123667 Versus Investigator's Choice of Chemotherapy in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression

RecruitingPhase 3
  • The University of Chicago Medicine, Chicago
Ages 18 and older · Women · Updated Sep 15, 2026 · NCT07214779

Investigation of Ubamatamab Combination Therapy in Adult Participants With Platinum-Resistant Ovarian Cancer

RecruitingPhase 2
  • University of Chicago, Chicago
Ages 18 and older · Women · Updated Sep 14, 2026 · NCT06787612

Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors

RecruitingPhase 1
  • University of Illinois Cancer Center, Chicago
  • University of Chicago Medicine, Chicago
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06293898

Phase II Study of the Effects of Laparoscopic Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Patients With Advanced Gastric Cancer

RecruitingPhase 2
  • University of Chicago, Chicago
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT04107077

Phase 1, Safety and Tolerability Study of XmAb541 in Advanced Solid Tumors

RecruitingPhase 1
  • University of Chicago Medical Center, Chicago
Ages 15 and older · All sexes · Updated Aug 25, 2026 · NCT06276491

Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

RecruitingPhase 1/2
  • Lurie Children's Hospital-Chicago, Chicago
12 Months – 30 Years · All sexes · Updated Aug 25, 2026 · NCT04851119

Testing the Addition of Paclitaxel Administered Into the Abdominal Cavity Combined With Chemotherapy for Patients With Gastric Cancer Spread to the Abdominal Cavity

RecruitingPhase 2/3
  • Northwestern University, Chicago
  • University of Chicago Comprehensive Cancer Center, Chicago
  • Northwestern Medicine Cancer Center Old Irving Park, Chicago
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT07001748

A Study of PHST001 in Advanced Solid Tumors

RecruitingPhase 1
  • University of Chicago Medical Center, Chicago
Ages 18 and older · All sexes · Updated Aug 12, 2026 · NCT06840886

Study of AZD9574 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Advanced Solid Malignancies

RecruitingPhase 1/2
  • Research Site, Chicago
Ages 18 to 130 · All sexes · Updated Aug 12, 2026 · NCT05417594

A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

Recruiting
  • Northwestern University, Chicago
  • Rush MD Anderson Cancer Center, Chicago
  • University of Illinois, Chicago
  • and 2 more
Ages 35 to 50 · Women · Updated Aug 7, 2026 · NCT04251052

Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer

RecruitingPhase 3
  • John H Stroger Jr Hospital of Cook County, Chicago
  • University of Illinois, Chicago
  • University of Chicago Comprehensive Cancer Center, Chicago
  • and 1 more
Ages 18 and older · All sexes · Updated Aug 7, 2026 · NCT06580314

A Trial to Evaluate Safety, Tolerability, and Preliminary Efficacy of Misetionamide (GP-2250) as Monotherapy or in Combination With Gemcitabine

RecruitingPhase 1
  • Rush University Medical Center, Chicago
Ages 18 and older · Women · Updated Jul 23, 2026 · NCT03854110

Immunotherapy Platform Study in Platinum Resistant High Grade Serous Ovarian Cancer

RecruitingPhase 2
  • The University of Chicago Medical Center, Chicago
Ages 18 and older · Women · Updated Jul 21, 2026 · NCT04918186

An Evaluation of Maintenance Therapy Combination Mirvetuximab Soravtansine and Olaparib

RecruitingPhase 2
  • Northwestern Memorial Hospital, Chicago
Ages 18 to 100 · Women · Updated Jul 13, 2026 · NCT05887609

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

RecruitingPhase 1
  • UChicago Medicine - River East, Chicago
  • The University Of Chicago, Chicago
  • University of Chicago Medical Center, Chicago
Ages 18 and older · All sexes · Updated Jul 6, 2026 · NCT04389632

A Study of Emiltatug Ledadotin (Emi-Le) in Participants With Solid Tumors

RecruitingPhase 1/2
  • Northwestern University, Chicago
Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT05377996

Physical Activity Intervention Among Older Women With Gynecologic Cancers (Fit4Treatment)

Recruiting
  • Northwestern University, Chicago
Ages 60 and older · Women · Updated May 29, 2026 · NCT05743517

ACTengine® IMA203/IMA203CD8 as Monotherapy or in Combination With Nivolumab in Recurrent and/or Refractory Solid Tumors

RecruitingPhase 1/2
  • University of Chicago Medical Center, Chicago
Ages 18 and older · All sexes · Updated May 13, 2026 · NCT03686124

TUBectomy With Delayed Oophorectomy in High Risk Women to Assess the Safety of Prevention

Recruiting
  • UChicago Medicine, Chicago
Ages 25 to 50 · Women · Updated Apr 6, 2026 · NCT04294927

A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies

RecruitingPhase 1/2
  • University of Chicago Medical Center, Chicago
Ages 18 and older · All sexes · Updated Mar 27, 2026 · NCT06395519

Alternate Day Fasting After Surgery for Patients Undergoing Chemotherapy

Recruiting
  • Northwestern Memorial Hospital, Chicago
Ages 18 and older · Women · Updated Mar 24, 2026 · NCT05990426

A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

RecruitingPhase 1
  • The University of Chicago Comprehensive Cancer Center, Chicago
Ages 18 and older · All sexes · Updated Feb 13, 2026 · NCT06778863

CATALINA-2: A Clinical Study of TORL-1-23 in Platinum-resistant Ovarian Cancer.

RecruitingPhase 2
  • University of Chicago Medical Center, Chicago
Ages 18 and older · Women · Updated Dec 23, 2025 · NCT06690775

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Chicago
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

Specimen and Data Study for Ovarian Cancer Early Detection and Prevention

RecruitingObservational studyHealthy volunteers welcome
  • Robert H. Lurie Comprehensive Cancer Center at Northwestern University, Chicago
Ages 18 to 80 · Women · Updated Feb 28, 2025 · NCT00005095

CPI-613 (Devimistat) in Combination With Hydroxychloroquine and 5-fluorouracil or Gemcitabine in Treating Patients With Advanced Chemorefractory Solid Tumors

RecruitingPhase 2
  • Northwestern University, Chicago
Ages 18 and older · All sexes · Updated Mar 10, 2023 · NCT05733000

About Ovarian Cancer

Ovarian cancer is a cancerous tumor that forms in the tissues of an ovary. The ovaries are a pair of female reproductive glands that make eggs and female hormones.

More about Ovarian Cancer on MedlinePlus

Ovarian Cancer trials in other cities

Other studies in Chicago

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.