🔎 Trials Near Me

Home › Colorectal Cancer › Missouri › St. Louis

Colorectal Cancer clinical trials in St. Louis, MO

50 studies for Colorectal Cancer are looking for participants at sites in and around St. Louis (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

The Vanguard Study: Testing a New Way to Screen for Cancer

RecruitingHealthy volunteers welcome
  • Washington University School of Medicine, St Louis
Ages 45 to 75 · All sexes · Updated Oct 5, 2026 · NCT06995898

A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Colorectal Cancer

RecruitingPhase 2
  • Washington University, St Louis
Ages 18 and older · All sexes · Updated Oct 5, 2026 · NCT07659795

A Phase 1 Study of PLN-101095 in Adults With Advanced or Metastatic Solid Tumors

RecruitingPhase 1
  • Washington University Medicine, St Louis
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06270706

Colonoscopy vs Stool Testing for Older Adults With Colon Polyps

Recruiting
  • Washington University School of Medicine, St Louis
Ages 65 to 82 · All sexes · Updated Oct 2, 2026 · NCT05612347

Family Communications After Genetic Testing

RecruitingHealthy volunteers welcome
  • Mercy Infusion Center - Chippewa, St Louis
  • Mercy Hospital South, St Louis
  • Missouri Baptist Medical Center, St Louis
  • and 4 more
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT07143487

Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, ERASur Trial

RecruitingPhase 2
  • Mercy Hospital South, St Louis
  • Missouri Baptist Medical Center, St Louis
  • Mercy Hospital Saint Louis, St Louis
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT05673148

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • Mercy Infusion Center - Chippewa, St Louis
  • Mercy Hospital South, St Louis
  • Missouri Baptist Medical Center, St Louis
  • and 4 more
Ages 40 to 75 · All sexes · Updated Oct 2, 2026 · NCT05334069

Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

RecruitingPhase 1
  • Washington University School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06625775

A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy

RecruitingPhase 3
  • Washington University School Of Medicine, St Louis
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06750094

Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing

RecruitingObservational study
  • Washington University, St Louis
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT04981119

Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors

RecruitingPhase 1
  • Research Site, St Louis
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06218914

A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer

RecruitingPhase 2/3
  • Washington University School OF Medicine-Siteman Cancer Center, St Louis
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07221357

A Study of LY4257496 in Participants With Cancer (OMNIRAY)

RecruitingPhase 1
  • Washington University, St Louis
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07114601

A Study of LY4337713 in Participants With FAP-Positive Solid Tumors

RecruitingPhase 1
  • Washington University School of Medicine in St. Louis, St Louis
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07213791

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

RecruitingPhase 1/2
  • Washington University, St Louis
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT05786924

A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer

RecruitingPhase 3
  • Washington University School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT07284849

Testing for Safety and Colorectal Cancer Preventive Effects of ONC201

RecruitingPhase 1
  • Washington University School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT05630794

Clinical Trial of an Anti-cancer Drug, CA-4948 (Emavusertib), in Combination With Chemotherapy Treatment (FOLFOX Plus Bevacizumab) in Metastatic Colorectal Cancer

RecruitingPhase 1
  • Washington University School of Medicine, St Louis
  • Siteman Cancer Center-South County, St Louis
  • Siteman Cancer Center at Christian Hospital, St Louis
  • and 2 more
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06696768

A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors

RecruitingPhase 1
  • Washington University School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06440005

Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer

RecruitingPhase 3
  • Clinical Study Site, O'Fallon · 16 mi away
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT07228832

Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

RecruitingPhase 1/2
  • Washington University School of Medicine, St Louis
12 Months – 30 Years · All sexes · Updated Aug 25, 2026 · NCT04851119

FOG-001 in Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
  • Washington University School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT05919264

IDOV-Immune for Advanced Solid Tumors

RecruitingPhase 1
  • Washington University School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT06910657

A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
  • Washington University, St Louis
Ages 18 and older · All sexes · Updated Jul 30, 2026 · NCT04657068

AMG 410 Alone and in Combination With Other Agents in Participants With KRAS Altered Advanced or Metastatic Solid Tumors

RecruitingPhase 1
  • Siteman Cancer Center - Washington University, St Louis
Ages 18 and older · All sexes · Updated Jul 30, 2026 · NCT07094113

A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors

RecruitingPhase 1/2
  • Washington University School of Medicine at St Louis, St Louis
Ages 18 and older · All sexes · Updated Jul 29, 2026 · NCT03526835

Study of Orally Administered MOMA-341 in Participants With Advanced or Metastatic Solid Tumors

RecruitingPhase 1
  • Investigative Site #110, St Louis
Ages 18 and older · All sexes · Updated Jul 23, 2026 · NCT06974110

Washington University Participant Engagement and Cancer Genomic Sequencing Center (WU-PE-CGS)

Recruiting
  • Washington University School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Jul 14, 2026 · NCT06340646

CARE Tool Study Aim 3

Recruiting
  • Washington University School of Medicine, St Louis
  • Alton Memorial Hospital, Alton · 18 mi away
Ages 18 and older · All sexes · Updated Jul 8, 2026 · NCT07296887

A Trial to Evaluate the Safety and Activity of Fruquintinib in Minority Populations With Advanced, Previously Treated Colorectal Cancer

RecruitingPhase 4
  • SSM Health St. Louis DePaul Hospital, St Louis
  • Washington University School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Jul 7, 2026 · NCT06562543

Lead-212 PSV359 Therapy for Patients With Solid Tumors

RecruitingPhase 1/2
  • Saint Louis University, St Louis
Ages 18 to 90 · All sexes · Updated Jul 6, 2026 · NCT06710756

Predicting Response to Immunotherapy From Analysis of Live Tumor Biopsies (ELEPHAS-05)

RecruitingObservational study
  • Mercy Hospital - South, St Louis
  • Mercy Hospital -STL, St Louis
Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT07327489

A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression

RecruitingPhase 1/2
  • Washington University, St Louis
Ages 18 and older · All sexes · Updated Jun 12, 2026 · NCT06051695

A Study to Learn About Study Medicine ALTA3263 in Adults With Advanced Solid Tumors With KRAS Mutations

RecruitingPhase 1
  • Research Site, St Louis
Ages 18 and older · All sexes · Updated Jun 10, 2026 · NCT06835569

KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors

RecruitingPhase 1
  • Washington University School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Jun 8, 2026 · NCT06026410

A Study to Find a Suitable Dose of ASP5834 in Adults With Solid Tumors

RecruitingPhase 1
  • Washington University School of Medicine, St Louis
Ages 18 and older · All sexes · Updated May 18, 2026 · NCT07094204

A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors

RecruitingPhase 1/2
  • Washington University School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Apr 22, 2026 · NCT07020221

Evaluating Whether an Educational Website Called Current Together After Cancer (CTAC) Improves Follow-up Care for Colorectal Cancer Survivors

RecruitingPhase 3Healthy volunteers welcome
  • Mercy Infusion Center - Chippewa, St Louis
  • Mercy Hospital South, St Louis
  • Missouri Baptist Medical Center, St Louis
  • and 5 more
Ages 18 and older · All sexes · Updated Mar 31, 2026 · NCT07018869

Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

RecruitingObservational study
  • Mercy Hospital South, St Louis
  • Missouri Baptist Medical Center, St Louis
  • Mercy Hospital Saint Louis, St Louis
  • and 4 more
Ages 18 and older · All sexes · Updated Mar 17, 2026 · NCT06418204

Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
  • Washington University, St Louis
Ages 18 and older · All sexes · Updated Feb 18, 2026 · NCT07030257

Ultrasound and Photoacoustic Imaging for Enhanced Differential Diagnosis of Rectal Cancer

Recruiting
  • Washington University School of Medicine, St Louis
Ages 19 and older · All sexes · Updated Feb 12, 2026 · NCT04339374

JAB-23E73 in Adult Participants With Advanced Solid Tumors With KRAS Alteration

RecruitingPhase 1/2
  • Washington University, St Louis
Ages 18 and older · All sexes · Updated Jan 16, 2026 · NCT06973564

LOTUS-CC: An Observational Research Study to Uncover Subtypes of Cancer Cachexia

RecruitingObservational study
  • Mercy Hospital South, St Louis
  • Missouri Baptist Medical Center, St Louis
  • BJC Outpatient Center at Sunset Hills, Sunset Hills · 13 mi away
  • and 3 more
Ages 18 and older · All sexes · Updated Jan 9, 2026 · NCT06073431

Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer

RecruitingObservational study
  • Missouri Baptist Medical Center, St Louis
  • BJC Outpatient Center at Sunset Hills, Sunset Hills · 13 mi away
  • Cancer Care Center of O'Fallon, O'Fallon · 16 mi away
Ages 60 and older · All sexes · Updated Jan 8, 2026 · NCT03998202

Phase 1 Study Evaluating the Safety and PK of ADU-1805 in Advanced Solid Tumors

RecruitingPhase 1
  • Washington University Medical Campus, St Louis
Ages 18 and older · All sexes · Updated Dec 17, 2025 · NCT05856981

ColoSense Post-Approval Study

RecruitingObservational studyHealthy volunteers welcome
  • Decentralized Study, St Louis
Ages 18 and older · All sexes · Updated Nov 21, 2025 · NCT07069556

A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression

RecruitingPhase 1/2
  • Washington University, St Louis
Ages 18 and older · All sexes · Updated Sep 9, 2025 · NCT06682793

ColoCare Study - Colorectal Cancer Cohort

RecruitingObservational study
  • Washington University School of Medicine, St Louis
Ages 18 to 89 · All sexes · Updated Jun 13, 2025 · NCT02328677

Tempus CRC Surveillance Study: A ctDNA Biomarker Profiling Study of Patients With CRC Using NGS Assays

RecruitingObservational study
  • Washington University School of Medicine, St Louis
  • Mercy Clinic Oncology and Hematology - Sindelar Cancer Center, St Louis
  • Mercy Clinic Oncology and Hematology - David C. Pratt Cancer Center, St Louis
Ages 18 and older · All sexes · Updated May 6, 2025 · NCT05234177

About Colorectal Cancer

Colorectal cancer starts in the colon or rectum. It may not cause symptoms at first. Screening tests can help find it early, when treatment is most effective.

More about Colorectal Cancer on MedlinePlus

Colorectal Cancer trials in other cities

Other studies in St. Louis

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.