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Prostate Cancer clinical trials in Cleveland, OH

34 studies for Prostate Cancer are looking for participants at sites in and around Cleveland (within about 30 miles). Open a study to see who can join and how to contact the study team.

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The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
  • The Cleveland Clinic Taussig Cancer Center, Cleveland
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750

Testing Different Dosing Schedules of the Anti-cancer Drug, Lutetium 177Lu PSMA RLT and Its Effect on Patients With Advanced Prostate Cancer, RECIPROCAL Trial

RecruitingPhase 3
  • MetroHealth Medical Center, Cleveland
Ages 18 and older · Men · Updated Oct 2, 2026 · NCT07200830

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

RecruitingPhase 1
  • University Hospitals Cleveland Medical Center, Cleveland
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06465069

Targeted Treatment for Metastatic Prostate Cancer, The PREDICT Trial

RecruitingPhase 2
  • MetroHealth Medical Center, Cleveland
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06632977

Cabazitaxel +/- Carboplatin vs 177Lu-PSMA-617 in Metastatic Castrate-resistant Prostate Cancer

RecruitingPhase 2
  • Case Comprehensive Cancer Center, University Hospitals Cleveland Medical Center Seidman Cancer Center, Cleveland Clinic Taussig Cancer Cente, Cleveland
Ages 19 and older · All sexes · Updated Oct 2, 2026 · NCT06738303

Barrigel® PPRT (Post-Prostatectomy Radiation Therapy) Trial

Recruiting
  • University Hospitals Cleveland Medical Center, Cleveland
Ages 18 and older · Men · Updated Sep 28, 2026 · NCT06496256

A Study of Pasritamig (JNJ-78278343) in Combination With JNJ-86974680 for Treatment of Prostate Cancer

RecruitingPhase 1
  • University Hospitals Cleveland Medical Center, Cleveland
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07319871

A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)

RecruitingPhase 3
  • University Hospitals Cleveland Medical Center ( Site 0043), Cleveland
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06136650

A Study of JNJ-78278343 in Combination With JNJ-95298177 for Treatment of Prostate Cancer

RecruitingPhase 1
  • University Hospitals Cleveland Medical Center, Cleveland
Ages 18 and older · Men · Updated Sep 25, 2026 · NCT07082920

This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.

RecruitingPhase 3
  • University Hospitals Cleveland Medical Center, Cleveland
  • UH Minoff Health Center at Chagrin Highlands, Orange · 12 mi away
  • University Hospitals Seidman Cancer Center at UH Mentor Health Center, Mentor · 22 mi away
Ages 18 and older · Men · Updated Sep 24, 2026 · NCT07028853

MDRT in Prostate Cancer Treated With Long-term Androgen Deprivation Therapy in the STAMPEDE Trial (METANOVA)

RecruitingPhase 2
  • University Hospitals Cleveland Medical Center Seidman Cancer Center, Cleveland
Ages 18 and older · Men · Updated Sep 15, 2026 · NCT06150417

Investigation of Impact of AI on Prostate Cancer Workflow

Recruiting
  • Cleveland Clinic Foundation, Cleveland
Ages 55 to 80 · All sexes · Updated Sep 15, 2026 · NCT07084779

Sacral Neuromodulation for Male Overactive Bladder (MOAB)

Recruiting
  • University Hospitals Cleveland, Cleveland
Ages 18 and older · Men · Updated Sep 14, 2026 · NCT06511141

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

RecruitingPhase 3
  • Case Western Reserve University, Cleveland
  • Louis Stokes Cleveland VA Medical Center, Cleveland
  • MetroHealth Medical Center, Cleveland
  • and 5 more
Ages 18 and older · Men · Updated Sep 10, 2026 · NCT05946213

The Vanguard Study: Testing a New Way to Screen for Cancer

RecruitingHealthy volunteers welcome
  • Louis Stokes Cleveland VA Medical Center, Cleveland
Ages 45 to 75 · All sexes · Updated Sep 2, 2026 · NCT06995898

AZD2265 Compared With Standard of Care in PSMA-positive Metastatic Castration-resistant Prostate Cancer (VECTRA-01)

RecruitingPhase 3
  • Research Site, Cleveland
Ages 18 and older · Men · Updated Aug 26, 2026 · NCT07611110

A Study of FG-3246 in Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC)

RecruitingPhase 2
  • University Hospitals Cleveland Medical Center, Cleveland
Ages 18 and older · Men · Updated Aug 17, 2026 · NCT06842498

FOG-001 in Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
  • University Hospitals Cleveland Medical Center, Seidman Cancer Center, Cleveland
  • Cleveland Clinic, Cleveland
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT05919264

Single-Port Transvesical Partial Prostatectomy Versus High Intensity Focused Ultrasound

Recruiting
  • Glickman Urological & Kidney Institute, Cleveland Clinic Foundation, Case Comprehensive Cancer Center, Cleveland
Ages 19 and older · Men · Updated Aug 6, 2026 · NCT05610852

Docetaxel to Androgen Receptor Pathway Inhibitors in Patients With Metastatic Castration Sensitive Prostate Cancer and Suboptimal PSA Response

RecruitingPhase 3
  • Case Western Reserve University, Cleveland
  • MetroHealth Medical Center, Cleveland
  • Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland
  • and 5 more
Ages 18 and older · Men · Updated Jul 14, 2026 · NCT06592924

A Study to Learn About Real-world Utilization and Outcomes of Darolutamide and Other Androgen Receptor Pathway Inhibitors (ARPIs) for Newly Diagnosed Metastatic Hormone-sensitive Prostate Cancer (de Novo mHSPC) in US Urology Clinics

RecruitingObservational study
  • Precision Point Specialty LLC PPS Analytics, a Specialty Networks LLC Company, Cleveland
Ages 18 and older · Men · Updated Jul 7, 2026 · NCT07406282

Long-Term Safety of Lutetium (177Lu) Vipivotide Tetraxetan in Participants With Prostate Cancer

RecruitingPhase 4
  • Cleveland Clinic Foundation, Cleveland
Ages 18 to 100 · Men · Updated Jun 4, 2026 · NCT05803941

STereotActic Body Radiotherapy and 177Lutetium PSMA in Locally Advanced Prostate Cancer

RecruitingPhase 1/2
  • University Hospitals Cleveland Medical Center Seidman Cancer Center, Case Comprehensive Cancer Center, Cleveland
Ages 18 and older · Men · Updated May 26, 2026 · NCT06574880

International Registry for Men With Advanced Prostate Cancer (IRONMAN)

RecruitingObservational study
  • University Hospitals Cleveland Medical Center, Cleveland
Ages 21 and older · Men · Updated May 22, 2026 · NCT03151629

A Phase I Study of [225Ac]-AZD2284 in Patients With Metastatic Castration-Resistant Prostate Cancer

RecruitingPhase 1
  • Research Site, Cleveland
Ages 18 and older · Men · Updated May 12, 2026 · NCT06879041

Evaluation of Prostate Specific Membrane Antigen Positron Emission Tomography-Computed Tomography in Active Surveillance for Prostate CancEr

Recruiting
  • UH Cleveland Medical Center, Cleveland
Ages 18 and older · Men · Updated May 4, 2026 · NCT05948657

Cleveland African American Prostate Cancer Project

RecruitingHealthy volunteers welcome
  • Barbershops Local to Cleveland, Cleveland
Ages 40 and older · Men · Updated Apr 8, 2026 · NCT05469269

Veterans Affairs Seamless Phase II/III Randomized Trial of STAndard Systemic theRapy With or Without PET-directed Local Therapy for Oligometastatic pRosTate Cancer

RecruitingPhase 2/3
  • Louis Stokes VA Medical Center, Cleveland, OH, Cleveland
Ages 18 and older · Men · Updated Apr 8, 2026 · NCT04787744

Metabolic Impact of Prospective Controlled Mediterranean Type Diets on Prostate Cancer

Recruiting
  • Case Comprehensive Cancer Center, Cleveland Clinic Foundation, Cleveland
Ages 18 and older · Men · Updated Feb 19, 2026 · NCT05590624

cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

RecruitingObservational studyHealthy volunteers welcome
  • Cleveland Clinic, Cleveland
Ages 40 and older · All sexes · Updated Jan 20, 2026 · NCT05366881

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Mayfield Heights · 12 mi away
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer

RecruitingPhase 3
  • MetroHealth Medical Center, Cleveland
Ages 18 and older · Men · Updated Sep 11, 2025 · NCT03678025

A Phase 1 Study of XL309 (ISM3091) Alone and in Combination in Participants With Advanced Solid Tumors

RecruitingPhase 1
  • Exelixis Clinical Site #7, Cleveland
Ages 18 and older · All sexes · Updated Sep 5, 2025 · NCT05932862

About Prostate Cancer

Prostate cancer is one of the most common types of cancer among American men. The risk goes up as men age. Learn about symptoms, tests, and treatment.

More about Prostate Cancer on MedlinePlus

Prostate Cancer trials in other cities

Other studies in Cleveland

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.