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Heart Failure clinical trials in Knoxville, TN

7 studies for Heart Failure are looking for participants at sites in and around Knoxville (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function

RecruitingPhase 3
  • Research Site, Knoxville
Ages 18 to 130 · All sexes · Updated Oct 2, 2026 · NCT06307652

A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure

RecruitingPhase 3
  • East Coast Institute For Research LLC, Jefferson City · 26 mi away
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06424288

Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

RecruitingPhase 3
  • Tennova Healthcare-Turkey Creek Medical Center, Knoxville
Ages 18 to 85 · All sexes · Updated Sep 24, 2026 · NCT06736574

Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

RecruitingPhase 3
  • Cardiovascular Research of Knoxville North Knoxville Medical Center, Powell · 8 mi away
  • Parkway Cardiology Associates, Oak Ridge · 20 mi away
Ages 18 to 99 · All sexes · Updated Sep 16, 2026 · NCT07037459

Alleviant ALLAY-HFrEF Study

Recruiting
  • Tennova Healthcare - Turkey Creek Medical Center, Knoxville
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT06812533

Alleviant ALLAY-HF Study

Recruiting
  • Tennova Healthcare - Turkey Creek Medical Center, Knoxville
Ages 40 and older · All sexes · Updated Aug 14, 2026 · NCT05685303

Pharmacy-led Transitions of Care Intervention to Improve Medication Adherence

Recruiting
  • University of Tennessee Medical Center, Knoxville
Ages 18 and older · All sexes · Updated Jan 29, 2026 · NCT06374277

About Heart Failure

Heart failure, or congestive heart failure (CHF), means the heart can't pump enough blood. Learn about the signs, symptoms, and causes.

More about Heart Failure on MedlinePlus

Heart Failure trials in other cities

Other studies in Knoxville

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.