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Major Depressive Disorder clinical trials in Columbus, OH

7 studies for Major Depressive Disorder are looking for participants at sites in and around Columbus (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms

RecruitingPhase 3
  • The Ohio State University, Columbus
Ages 18 to 74 · All sexes · Updated Nov 3, 2026 · NCT06559306

Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder

RecruitingPhase 3
  • The Ohio State University, Columbus
Ages 18 to 65 · All sexes · Updated Nov 3, 2026 · NCT05850689

A Mechanistic Study to Assess a Single Dose of CYB003 in Participants With Depression and Anxiety

RecruitingPhase 2
  • The Ohio State University Department of Psychiatry, Columbus
Ages 21 to 65 · All sexes · Updated Oct 20, 2026 · NCT06820723

Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

Recruiting
  • The Ohio State University, Columbus
Ages 22 to 70 · All sexes · Updated Oct 16, 2026 · NCT06423430

A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression

RecruitingPhase 2
  • Draig Clinical Site, Columbus
Ages 18 to 75 · All sexes · Updated Oct 14, 2026 · NCT07610473

A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder

RecruitingPhase 2
  • OSU Psychiatry Department /ID# 277529, Columbus
Ages 18 to 65 · All sexes · Updated Jun 15, 2026 · NCT07276997

Mechanisms of Rumination Change in Adolescent Depression

Recruiting
  • Nationwide Children's Hospital, Columbus
  • The Ohio State University, Columbus
Ages 14 to 17 · All sexes · Updated Aug 11, 2025 · NCT03859297

Major Depressive Disorder trials in other cities

Other studies in Columbus

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.