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Major Depressive Disorder clinical trials in Cleveland, OH

8 studies for Major Depressive Disorder are looking for participants at sites in and around Cleveland (within about 30 miles). Open a study to see who can join and how to contact the study team.

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Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder

RecruitingPhase 3
  • Quest Therapeutics of Avon Lake, Avon Lake · 17 mi away
Ages 18 to 65 · All sexes · Updated Sep 25, 2026 · NCT05850689

Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

Recruiting
  • The Cleveland Clinic Foundation, Cleveland
Ages 22 to 70 · All sexes · Updated Aug 28, 2026 · NCT06423430

Positive Processes and Transition to Health (PATH)

Recruiting
  • Case Western Reserve University, Cleveland
Ages 18 to 65 · All sexes · Updated Aug 19, 2026 · NCT06093906

A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)

RecruitingPhase 3
  • Cleveland Clinic, Cleveland
Ages 18 to 74 · All sexes · Updated Aug 10, 2026 · NCT07592689

Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, Avon Lake · 17 mi away
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT06966401

A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder

RecruitingPhase 2
  • Quest Therapeutics of Avon /ID# 277550, Avon Lake · 17 mi away
Ages 18 to 65 · All sexes · Updated Jun 15, 2026 · NCT07276997

Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder (AMPLIFY)

RecruitingPhase 2
  • Autobahn Site #109, Beachwood · 10 mi away
Ages 18 to 65 · All sexes · Updated Jan 20, 2026 · NCT06633016

Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, Avon Lake · 17 mi away
Ages 18 and older · All sexes · Updated Oct 29, 2025 · NCT06786624

Major Depressive Disorder trials in other cities

Other studies in Cleveland

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.