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Heart Failure clinical trials in Kansas City, MO

25 studies for Heart Failure are looking for participants at sites in and around Kansas City (within about 30 miles). Open a study to see who can join and how to contact the study team.

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ELEVATE-HFpEF Clinical Study

Recruiting
  • Saint Lukes Mid America Heart Institute, Kansas City
Ages 40 and older · All sexes · Updated Oct 2, 2026 · NCT06678841

Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function

RecruitingPhase 3
  • Research Site, Kansas City
  • Research Site, Kansas City
Ages 18 to 130 · All sexes · Updated Oct 2, 2026 · NCT06307652

A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure

RecruitingPhase 3
  • Kansas City VA Medical Center, Kansas City
  • North Kansas City Hospital, North Kansas City · 2 mi away
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06424288

A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart

RecruitingPhase 3
  • Kansas City VA Medical Center, Kansas City
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06935370

A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF

RecruitingPhase 3
  • Research Site, Kansas City
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07761117

Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

RecruitingPhase 3
  • Saint Luke's Hospital of Kansas City, Kansas City
Ages 18 to 85 · All sexes · Updated Sep 24, 2026 · NCT06736574

Barostim-Enabled NEurohormonal Intervention For Improving Treatment of Heart Failure

Recruiting
  • Saint Luke's Hospital of Kansas City, Kansas City
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07232030

Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

RecruitingPhase 3
  • Saint Luke's Hospital of Kansas City, Kansas City
Ages 18 to 99 · All sexes · Updated Sep 16, 2026 · NCT07037459

Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin

RecruitingPhase 3
  • Research Site, Kansas City
  • Research Site, Kansas City
Ages 40 and older · All sexes · Updated Sep 15, 2026 · NCT06677060

A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients

RecruitingPhase 3
  • Kansas City, MO Investigative Site 10002, Kansas City
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06008197

A Study to Determine the Efficacy and Safety of Finerenone and SGLT2i in Combination in Hospitalized Patients With Heart Failure (CONFIRMATION-HF)

RecruitingPhase 3
  • CON-10002 Kansas City, MO Investigative Site, Kansas City
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06024746

The WiSE®-UP Study (The WiSE System Utilization & Performance Study)

RecruitingObservational study
  • St. Luke's Hospital of Kansas City, Kansas City
Ages 22 and older · All sexes · Updated Sep 10, 2026 · NCT07098858

A Study of EDG-15400 in Adults With Heart Failure With Preserved Ejection Fraction (EQUINOX-HFpEF)

RecruitingPhase 2
  • Local Institution - 145, Kansas City
Ages 30 to 84 · All sexes · Updated Aug 31, 2026 · NCT07795814

Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products

RecruitingObservational study
  • Kansas City, Kansas City
All ages · All sexes · Updated Aug 20, 2026 · NCT00271180

LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2

RecruitingPhase 3
  • Tenax Investigational Site, Kansas City
Ages 18 to 85 · All sexes · Updated Aug 19, 2026 · NCT07288398

A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity

RecruitingPhase 3
  • Clinical Research Consultants, JCCT Co, Kansas City
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07567001

Assessment of CCM in HF With Higher Ejection Fraction

Recruiting
  • St. Lukes Hospital Kansas City (Mid America Heart Institute), Kansas City
Ages 18 and older · All sexes · Updated Aug 6, 2026 · NCT05064709

A Study to Evaluate Finerenone on Clinical Efficacy and Safety in Patients With Heart Failure Who Are Intolerant or Not Eligible for Treatment With Steroidal Mineralocorticoid Receptor Antagonists

RecruitingPhase 3
  • FIN-10002 Kansas City, MO Investigational Site, Kansas City
Ages 18 and older · All sexes · Updated Jul 10, 2026 · NCT06033950

PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III

Recruiting
  • St. Lukes/ Mid-American Heart Institute, Kansas City
Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT05934487

A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic Dysfunction

RecruitingPhase 3
  • Children's Mercy Hospital Kansas City - Cardiology, Kansas City
Up to age 18 · All sexes · Updated Jun 29, 2026 · NCT07192952

Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure

Recruiting
  • St. Luke's Hospital, Kansas City
Ages 18 and older · All sexes · Updated Jun 10, 2026 · NCT06526195

CCM OPEN HF Registry

RecruitingObservational study
  • Saint Luke's Hospital Mid America Heart Institute, Kansas City
  • Saint Luke's Hospital of Kansas City, Kansas City
Ages 18 and older · All sexes · Updated Apr 23, 2026 · NCT07112924

HF2 Registry - Hemodynamic Frontiers in Heart Failure Registry

RecruitingObservational study
  • Saint Luke's Health System, Kansas City
Ages 18 to 100 · All sexes · Updated May 22, 2024 · NCT06425848

About Heart Failure

Heart failure, or congestive heart failure (CHF), means the heart can't pump enough blood. Learn about the signs, symptoms, and causes.

More about Heart Failure on MedlinePlus

Heart Failure trials in other cities

Other studies in Kansas City

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.