🔎 Trials Near Me

Home › Major Depressive Disorder › California › San Francisco

Major Depressive Disorder clinical trials in San Francisco, CA

8 studies for Major Depressive Disorder are looking for participants at sites in and around San Francisco (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)

RecruitingPhase 3
  • UCSF Department of Neurology, San Francisco
Ages 18 to 74 · All sexes · Updated Oct 5, 2026 · NCT07592689

Near Infrared Spectroscopy (NIRS) for Assessment of Depression

RecruitingHealthy volunteers welcome
  • San Francisco Veterans Affairs Medical Center, San Francisco
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT04061148

NBI-1065845-MDD3025: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, San Francisco
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT06911112

Closed-Loop Deep Brain Stimulation for Major Depression

Recruiting
  • University of California, San Francisco, San Francisco
Ages 22 to 70 · All sexes · Updated Aug 3, 2026 · NCT04004169

A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder

RecruitingPhase 2
  • Studyops Inc, San Francisco
Ages 18 to 64 · All sexes · Updated Jul 27, 2026 · NCT07115329

Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, San Francisco
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT06966401

Biomarkers of Depression and Treatment Response

Recruiting
  • University of California, San Francisco, San Francisco
Ages 18 to 70 · All sexes · Updated Jan 30, 2026 · NCT04581902

Characterizing Cognitive Decline in Late Life Depression: The ADNI Depression Project

RecruitingObservational study
  • University of California, San Francisco, San Francisco
Ages 65 and older · All sexes · Updated Nov 25, 2025 · NCT02434393

Major Depressive Disorder trials in other cities

Other studies in San Francisco

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.