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Major Depressive Disorder clinical trials in Dallas, TX

9 studies for Major Depressive Disorder are looking for participants at sites in and around Dallas (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder

RecruitingPhase 3
  • Future Search Trials of Dallas, Dallas
Ages 18 to 74 · All sexes · Updated Oct 1, 2026 · NCT07573176

A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 2
  • FutureSearch Trials of Dallas, Dallas
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07621237

A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)

RecruitingPhase 2
  • Seaport Investigator Site, Dallas
Ages 18 to 65 · All sexes · Updated Sep 14, 2026 · NCT07065240

Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

Recruiting
  • University of Texas Southwestern Medical Center at Dallas, Dallas
Ages 22 to 70 · All sexes · Updated Aug 28, 2026 · NCT06423430

Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, Dallas
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT06966401

Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol

RecruitingPhase 3
  • Clinical Research Site, Dallas
Ages 18 to 65 · All sexes · Updated Jul 24, 2026 · NCT07484217

Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services

RecruitingObservational study
  • University of Texas Southwestern Medical Center, Dallas
Ages 18 to 40 · All sexes · Updated Mar 10, 2026 · NCT06740383

Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, Dallas
Ages 18 and older · All sexes · Updated Oct 29, 2025 · NCT06786624

A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms

RecruitingPhase 4
  • Clinical Research Site, Dallas
  • Clinical Research Site, Dallas
Ages 18 to 65 · All sexes · Updated Jan 23, 2025 · NCT06223880

Major Depressive Disorder trials in other cities

Other studies in Dallas

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.