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Alzheimer's Disease clinical trials in Philadelphia, PA

15 studies for Alzheimer's Disease are looking for participants at sites in and around Philadelphia (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

A Study to Investigate the Safety and Effectiveness of SAR448851 in Participants With Early Alzheimer's Disease

RecruitingPhase 2
  • Flourish Research - Keystone Clinical Studies- Site Number : 8400003, Plymouth Meeting · 12 mi away
Ages 55 to 85 · All sexes · Updated Sep 22, 2026 · NCT07688213

A Study of Donanemab (LY3002813) in Participants With Early Cognitive Decline (TRAILBLAZER-ALZ 7)

RecruitingPhase 2
  • Pennsylvania Hospital, Philadelphia
Ages 55 to 85 · All sexes · Updated Sep 22, 2026 · NCT07589595

Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies

RecruitingPhase 3
  • Flourish Research ? Philadelphia, Plymouth Meeting · 12 mi away
Ages 50 to 90 · All sexes · Updated Sep 21, 2026 · NCT07177352

PET Imaging Tau Accumulation in FTLD and Atypical Alzheimer's Using [18F]-PI-2620

RecruitingPhase 3Healthy volunteers welcome
  • Perelman Center for Advance Medicine, Philadelphia
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT05456503

A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease (MINDSET 2)

RecruitingPhase 3
  • Keystone Clinical Studies, Plymouth Meeting · 12 mi away
Ages 60 to 85 · All sexes · Updated Sep 17, 2026 · NCT06976203

Evaluating Novel Healthcare Approaches to Nurturing and Caring for Hospitalized Elders

Recruiting
  • Hospital of the University of Pennsylvania, Philadelphia
Ages 70 and older · All sexes · Updated Sep 8, 2026 · NCT05929703

Tau PET/CT Imaging in the Mismatch Prospective Cohort Study (MPC-TAU)

RecruitingObservational study
  • University of Pennsylvania, Philadelphia
Ages 18 to 120 · All sexes · Updated Sep 4, 2026 · NCT05658913

Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986368, for the Treatment of Agitation in Participants With Alzheimer's Disease

RecruitingPhase 2
  • Thomas Jefferson University - Vickie & Jack Farber Institute for Neuroscience, Philadelphia
Ages 55 to 90 · All sexes · Updated Sep 1, 2026 · NCT06808984

Biofluid Research on Age-Related or Inherited Neurodegeneration

RecruitingObservational studyHealthy volunteers welcome
  • University of Pennsylvania, Philadelphia
Ages 18 and older · All sexes · Updated Sep 1, 2026 · NCT07798700

A Clinical Study of MK-2214 in People With Early Alzheimer's Disease (MK-2214-004)

RecruitingPhase 2
  • Flourish Research ( Site 1048), Plymouth Meeting · 12 mi away
Ages 50 to 85 · All sexes · Updated Aug 26, 2026 · NCT07033494

Using the EHR to Advance Genomic Medicine Across a Diverse Health System

Recruiting
  • Penn Medicine, Philadelphia
Ages 18 and older · All sexes · Updated Aug 14, 2026 · NCT06377033

Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant

RecruitingPhase 3
  • Penn Presbyterian Medical Center, Philadelphia
Ages 18 to 75 · All sexes · Updated Aug 4, 2026 · NCT06563895

A Clinical Trial to Learn About the Effects of VHB937 in People With Early Alzheimer's Disease

RecruitingPhase 2
  • Abington Neurological Associates Ltd, Willow Grove · 13 mi away
Ages 50 to 85 · All sexes · Updated Jun 26, 2026 · NCT07094516

UPenn Observational Research Repository on Neurodegenerative Disease

RecruitingObservational studyHealthy volunteers welcome
  • University of Pennsylvania, Philadelphia
Ages 18 and older · All sexes · Updated Jan 22, 2026 · NCT04715399

Study of Biodistribution, Metabolism, Excretion and Brain Uptake 18F-JSS20-183A

RecruitingEarly phase 1
  • University of Pennsylvania, Philadelphia
Ages 40 to 85 · All sexes · Updated Dec 23, 2025 · NCT06932809

About Alzheimer's Disease

Alzheimer's disease is a brain disorder that slowly destroys memory and thinking skills. It's the most common cause of dementia among older adults.

More about Alzheimer's Disease on MedlinePlus

Alzheimer's Disease trials in other cities

Other studies in Philadelphia

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.