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HIV clinical trials in Philadelphia, PA

11 studies for HIV are looking for participants at sites in and around Philadelphia (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Implementation Study of Lenacapavir Pre-exposure Prophylaxis for HIV Prevention

RecruitingObservational study
  • Perelman Center for Advanced Medicine, Philadelphia
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT07473778

A Study to Investigate Cabotegravir Ultra Long-Acting (CAB ULA) Plus Rilpivirine Ultra Long-Acting (RPV ULA) in Adults and Adolescents With HIV Who Are Virologically Suppressed

RecruitingPhase 3
  • GSK Investigational Site, Philadelphia
Ages 12 and older · All sexes · Updated Sep 28, 2026 · NCT07650916

A Clinical Study of Islatravir and Ulonivirine for People With HIV-1 Who Have Not Been Treated Before (MK-8591B-062)

RecruitingPhase 2/3
  • University of Pennsylvania Perelman School of Medicine ( Site 1508), Philadelphia
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT07266831

Clinical Trial to Evaluate the Safety and Immunogenicity of Hiltonol, Poly-ICLC-adjuvanted CD40.HIVRI.Env (VRIPRO) in Adult Participants Who Previously Participated in HVTN 706

RecruitingPhase 1Healthy volunteers welcome
  • Penn Prevention CRS (Site ID# 30310), Philadelphia
Ages 18 to 60 · All sexes · Updated Sep 18, 2026 · NCT06665646

Impact of Behavior Modification Interventions and Lung Cancer Screening on Smoking Cessation in People Living With HIV: A Feasibility Study

Recruiting
  • Thomas Jefferson University, Philadelphia
Ages 45 to 80 · All sexes · Updated Aug 19, 2026 · NCT04949464

Immune Cell Therapy (CAR-T) for the Treatment of Patients With HIV and B-Cell Non-Hodgkin Lymphoma

RecruitingPhase 1
  • University of Pennsylvania / Abramson Cancer Center, Philadelphia
Ages 18 and older · All sexes · Updated Jul 10, 2026 · NCT05077527

Kidney Transplantation From Donors With HIV: Impact on Rejection and Long-Term Outcomes (Expanding HOPE Kidney)

Recruiting
  • University of Pennsylvania, Philadelphia
Ages 18 and older · All sexes · Updated Jun 22, 2026 · NCT06263426

Menopausal HT for Women Living With HIV (HoT)

RecruitingPhase 4
  • 6201 Penn Therapeutics CRS, Philadelphia
Ages 40 to 60 · Women · Updated May 22, 2026 · NCT06856174

Enhancing the Organizational Social Context to Improve Viral Suppression and Retention in HIV Care

Recruiting
  • University of Pennsylvania, Philadelphia
Ages 18 and older · All sexes · Updated May 19, 2026 · NCT06462807

The Collaborative Care PrTNER Study

RecruitingHealthy volunteers welcome
  • Children's Hospital of Philadelphia, Philadelphia
Ages 15 to 29 · Men · Updated May 18, 2026 · NCT06585631

Screen Smart: Using Digital Health to Improve HIV Screening and Prevention

RecruitingHealthy volunteers welcome
  • Children's Hospital of Philadelphia, Philadelphia
Ages 15 to 21 · All sexes · Updated May 4, 2025 · NCT06003192

About HIV

HIV (human immunodeficiency virus) attacks the body’s immune system. There is no cure but it can be treated with medicines. To know if you have HIV, get tested.

More about HIV on MedlinePlus

HIV trials in other cities

Other studies in Philadelphia

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.