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Retinal Imaging in Neurodegenerative Disease

RecruitingObservational studyHealthy volunteers welcome

Evaluating the Retinal and Choroidal Microvasculature and Structure Using Multimodal Retinal and Choroidal Imaging in Neurodegenerative Disease: iMIND Research Study

Who can join

Ages 18 and older · All sexes · Healthy volunteers welcome

Full eligibility criteria

Inclusion Criteria:

* Adults with neurodegenerative disease ((MCI, PD, AD, FTD, DLB, ALS, MS, HD, TBI, concussion, PTSD and other neurodegenerations as well as Down Syndrome)
* Adults without neurodegenerative disease

Exclusion Criteria:

* Inability to cooperate with or complete testing or other neurologic or age- related ocular conditions that would impact image acquisition.
* Eyes that have had intraocular surgery, other than cataract surgery.

If two eyes satisfy the inclusion criteria, both eyes will be included in the study. If one eye satisfies the inclusion criteria, the eye that qualifies will be included in the study.

About the study

This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the retinal and choroidal microvasculature and structure in persons with mild cognitive impairment (MCI) and Alzheimer's Disease (AD), Parkinson's Disease (PD), or other neurodegenerative disease, diseases as outlined.

What is being tested

Retinal and Choroidal Imaging (device)

Sponsor: Duke University · Participants: 2,000 · Started: Jul 20, 2017

Contact the study team

Sharon Fekrat, MD FACS FASRS · Phone: 919-681-3937

Official record on ClinicalTrials.gov — NCT03233646

Locations in the U.S.

North Carolina

Duke University Medical Center, Durham

Conditions

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.