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Overweight clinical trials recruiting in the U.S.

205 studies for Overweight are recruiting participants at sites across the United States.

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Recently updated studies

Safety and Efficacy of ABBV-295 in Adults With Obesity or Overweight With Weight-Related Comorbidities

RecruitingPhase 2
Ages 18 to 75 ยท All sexes ยท Updated Oct 2, 2026 ยท NCT07752979

Effects of Pistachios on Postprandial Metabolic Responses in Adults With Overweight or Obesity

Recruiting
Ages 18 to 35 ยท All sexes ยท Updated Oct 2, 2026 ยท NCT07853898

A Study to Evaluate Safety, Tolerability and Pharmacokinetics of Orally Administered TIX100 in Healthy Subjects

RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 70 ยท All sexes ยท Updated Oct 2, 2026 ยท NCT07675590

Hydration Intervention to Decrease Side Effects Associated With GLP - 1 RA Therapy

Recruiting
Ages 18 to 60 ยท All sexes ยท Updated Oct 2, 2026 ยท NCT07641361

Effects of Sucralose on Drug Absorption and Metabolism (The SweetMeds Study)

RecruitingPhase 2Healthy volunteers welcome
Ages 18 to 60 ยท Women ยท Updated Oct 2, 2026 ยท NCT03407079

Comparing the Efficacy and Safety of the EndoZip System and Apollo ESG in Obese Patients

Recruiting
Ages 21 to 65 ยท All sexes ยท Updated Oct 1, 2026 ยท NCT07090005

A Study to Evaluate the Impact of Renal Impairment on the Pharmacokinetics (PK) of Ribupatide

RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 85 ยท All sexes ยท Updated Oct 1, 2026 ยท NCT07793929

Two-Week Stair-Climbing Exercise Snacks and Metabolic Health in Adults With Overweight or Obesity: A Pilot Study

RecruitingHealthy volunteers welcome
Ages 18 to 35 ยท All sexes ยท Updated Sep 30, 2026 ยท NCT07849439

AMAZE 2: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight

RecruitingPhase 3
Ages 18 and older ยท All sexes ยท Updated Sep 30, 2026 ยท NCT07533175

A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Excess Body Weight

RecruitingPhase 3
Ages 8 to 18 ยท All sexes ยท Updated Sep 30, 2026 ยท NCT07253285

FAMily-centered WEight Loss for Black Adults (FAM WEL B-ing)

Recruiting
Ages 18 to 75 ยท All sexes ยท Updated Sep 29, 2026 ยท NCT06724406

Study of Olatorepatide in Adult Participants Living With Overweight or Obesity Without Diabetes

RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Sep 29, 2026 ยท NCT07685808

Study to Assess the Effect and Safety of ALV-100 on Maintenance of Weight Loss

RecruitingPhase 2
Ages 18 to 75 ยท All sexes ยท Updated Sep 28, 2026 ยท NCT07837973

AMAZE 9: A Research Study Investigating How Well Zenagamtide Tablets Help People With Excess Body Weight Lose Weight

RecruitingPhase 3
Ages 18 and older ยท All sexes ยท Updated Sep 28, 2026 ยท NCT07720271

Physical and Behavioral Traits of Overweight and Obese Adults

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 100 ยท All sexes ยท Updated Sep 28, 2026 ยท NCT00428987

Study of ALV-100 to Assess Safety, Tolerability, and PK/PD in Overweight/Obese Participants With or Without T2D

RecruitingPhase 1
Ages 18 to 65 ยท All sexes ยท Updated Sep 28, 2026 ยท NCT07399678

A Research Study Investigating How Well the Medicine Zenagamtide Helps People With Excess Body Weight Lose Weight Compared to Semaglutide

RecruitingPhase 3
Ages 18 and older ยท All sexes ยท Updated Sep 28, 2026 ยท NCT07668414

A Study of Orforglipron in Participants With Overweight at Risk of Development of Obesity-Related Complications or Progression to Class 1 Obesity

RecruitingPhase 3
Ages 18 and older ยท All sexes ยท Updated Sep 28, 2026 ยท NCT07794579

A Study to Learn About the Study Medicine Called Berobenatide (PF-08653944) in People With Overweight or Obesity

RecruitingPhase 3
Ages 18 and older ยท All sexes ยท Updated Sep 28, 2026 ยท NCT07595549

Safety and Drug Concentrations of REGN20934 in Adults With Overweight or Obesity

RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 65 ยท All sexes ยท Updated Sep 25, 2026 ยท NCT07594093

Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight

RecruitingPhase 3
Ages 18 to 70 ยท All sexes ยท Updated Sep 24, 2026 ยท NCT06937099

A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)

RecruitingPhase 3
Ages 6 to 17 ยท All sexes ยท Updated Sep 24, 2026 ยท NCT06672549

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.