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Heart Failure clinical trials in Nashville, TN

19 studies for Heart Failure are looking for participants at sites in and around Nashville (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

ELEVATE-HFpEF Clinical Study

Recruiting
  • Saint Thomas Research Institute, Nashville
Ages 40 and older · All sexes · Updated Oct 2, 2026 · NCT06678841

Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function

RecruitingPhase 3
  • Research Site, Nashville
Ages 18 to 130 · All sexes · Updated Oct 2, 2026 · NCT06307652

Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

RecruitingPhase 3
  • Vanderbilt University Medical Center, Nashville
Ages 18 to 85 · All sexes · Updated Sep 24, 2026 · NCT06736574

Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin

RecruitingPhase 3
  • Research Site, Nashville
Ages 40 and older · All sexes · Updated Sep 15, 2026 · NCT06677060

A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients

RecruitingPhase 3
  • Nashville, TN Investigative Site 10071, Nashville
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06008197

Safety and Effectiveness of Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart Failure

Recruiting
  • St.Thomas Health, Nashville
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT07069738

Optimal Pediatric Heart Transplant Immunosuppression With MicroRNAs

RecruitingObservational study
  • Vanderbilt University, Nashville
Up to age 18 · All sexes · Updated Aug 25, 2026 · NCT06532890

Sodium/Glucose Cotransporter-2 Inhibitors (SGLT2i) Therapy in Duchenne Cardiomyopathy

RecruitingPhase 1
  • Vanderbilt University Medical Center, Nashville
Ages 8 to 18 · Men · Updated Aug 24, 2026 · NCT07172971

Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products

RecruitingObservational study
  • Nashville, Nashville
All ages · All sexes · Updated Aug 20, 2026 · NCT00271180

A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM)

RecruitingObservational study
  • Tristar Centennial Medical Ctr, Nashville
  • Saint Thomas Health, Nashville
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT05489705

LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2

RecruitingPhase 3
  • Tenax Investigational Site, Nashville
Ages 18 to 85 · All sexes · Updated Aug 19, 2026 · NCT07288398

OPtimal Adult Heart Transplant Immunosuppression With MicroRNA Levels

RecruitingObservational study
  • Vanderbilt University, Nashville
Ages 18 to 99 · All sexes · Updated Aug 11, 2026 · NCT06939751

PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III

Recruiting
  • Vanderbilt, Nashville
Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT05934487

Wearable Technology to Evaluate Hyperglycemia and HRV in DMD

RecruitingObservational studyHealthy volunteers welcome
  • Vanderbilt University Medical Center, Nashville
Ages 10 and older · Men · Updated May 22, 2026 · NCT06124196

The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR

Recruiting
  • Centennial Medical Center, Nashville
Ages 18 and older · All sexes · Updated Apr 13, 2026 · NCT03142152

XVIVO Heart Box (XHB) With Supplemented XVIVO Heart Solution (SXHS) Continued Access Protocol (CAP)

Recruiting
  • Vanderbilt University Medical Center, Nashville
Ages 18 and older · All sexes · Updated Mar 18, 2026 · NCT06895070

Wearable Technology to Evaluate Hyperglycemia and HRV in DMD - Longitudinal Aim

RecruitingObservational study
  • Vanderbilt University Medical Center, Nashville
Ages 10 and older · Men · Updated Nov 6, 2025 · NCT06093100

AN INTERNATIONAL, OBSERVATIONAL, BLINDED STUDY TO ASSESS THE PERFORMANCE OF THE CORDIO HEARO SYSTEM

RecruitingObservational study
  • Vanderbilt University Medical Center, Nashville
Ages 22 and older · All sexes · Updated Mar 26, 2025 · NCT06378632

About Heart Failure

Heart failure, or congestive heart failure (CHF), means the heart can't pump enough blood. Learn about the signs, symptoms, and causes.

More about Heart Failure on MedlinePlus

Heart Failure trials in other cities

Other studies in Nashville

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.