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Depression clinical trials in Washington, DC

15 studies for Depression are looking for participants at sites in and around Washington (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers

RecruitingObservational studyHealthy volunteers welcome
  • National Institutes of Health Clinical Center, Bethesda · 7 mi away
Ages 3 to 99 · All sexes · Updated Oct 2, 2026 · NCT00024635

Long-term Observation of Participants With Mood Disorders

RecruitingObservational studyHealthy volunteers welcome
  • National Institutes of Health Clinical Center, Bethesda · 7 mi away
Ages 18 to 99 · All sexes · Updated Oct 1, 2026 · NCT04877977

[18F]PF-06445974 to Image PDE4B in Major Depressive Disorder Using PET

RecruitingPhase 1Healthy volunteers welcome
  • National Institutes of Health Clinical Center, Bethesda · 7 mi away
Ages 18 to 70 · All sexes · Updated Oct 1, 2026 · NCT05703685

Natural History of Depression, Bipolar Disorder and Suicide Risk

RecruitingObservational study
  • National Institutes of Health Clinical Center, Bethesda · 7 mi away
Ages 18 to 120 · All sexes · Updated Oct 1, 2026 · NCT06462196

Characterization and Treatment of Adolescent Depression

RecruitingObservational studyHealthy volunteers welcome
  • National Institutes of Health Clinical Center, Bethesda · 7 mi away
Ages 11 to 25 · All sexes · Updated Sep 28, 2026 · NCT03388606

Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder

RecruitingPhase 1Healthy volunteers welcome
  • National Institutes of Health Clinical Center, Bethesda · 7 mi away
Ages 18 to 65 · All sexes · Updated Sep 22, 2026 · NCT03065335

Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression

RecruitingPhase 2
  • National Institutes of Health Clinical Center, Bethesda · 7 mi away
Ages 18 to 70 · All sexes · Updated Sep 14, 2026 · NCT06511908

Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression

RecruitingPhase 1
  • National Institutes of Health Clinical Center, Bethesda · 7 mi away
Ages 18 to 70 · All sexes · Updated Sep 10, 2026 · NCT03973268

Neurobiology of Suicide

RecruitingPhase 2Healthy volunteers welcome
  • National Institutes of Health Clinical Center, Bethesda · 7 mi away
Ages 18 to 70 · All sexes · Updated Sep 9, 2026 · NCT02543983

PET Imaging of Cyclooxygenase in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 1Healthy volunteers welcome
  • National Institutes of Health Clinical Center, Bethesda · 7 mi away
Ages 18 to 70 · All sexes · Updated Aug 18, 2026 · NCT04582916

E-Mindfulness Approaches for Living After Breast Cancer

RecruitingPhase 3
  • Kaiser Permanente-Capitol Hill Medical Center, Washington D.C.
  • MedStar Georgetown University Hospital, Washington D.C.
  • MedStar Washington Hospital Center, Washington D.C.
  • and 2 more
Ages 18 to 50 · All sexes · Updated Aug 4, 2026 · NCT06748222

CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms

Recruiting
  • Walter Reed National Medical Military Center, Bethesda · 7 mi away
Ages 18 and older · All sexes · Updated Jul 13, 2026 · NCT05663034

Does Social Media Impact Adolescent Mental Health?

RecruitingHealthy volunteers welcome
  • Georgetown University, Washington D.C.
Ages 10 to 14 · All sexes · Updated Jul 8, 2026 · NCT06049888

The Exhale Study: Treating Maternal Depression in an Urban Pediatric Asthma Clinic

Recruiting
  • Children's National Hospital, Washington D.C.
All ages · All sexes · Updated Feb 24, 2026 · NCT06623981

Pragmatic Clinic-Based Trial of a Mindfulness Based Intervention for Mood Concerns in Youth With Type 1 Diabetes

Recruiting
  • Children's National Hospital, Washington D.C.
Ages 13 to 17 · All sexes · Updated Jul 8, 2025 · NCT06618027

About Depression

Depression is a serious medical illness. It affects almost 7 percent of U.S. adults. It causes feelings of sadness, hopelessness, and frustration that do not go away. Learn about treatments.

More about Depression on MedlinePlus

Depression trials in other cities

Other studies in Washington

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.