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Depression clinical trials in Houston, TX

18 studies for Depression are looking for participants at sites in and around Houston (within about 30 miles). Open a study to see who can join and how to contact the study team.

A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder

RecruitingPhase 3
  • Brain Health Consultants and TMS Center, Houston
Ages 18 to 85 · All sexes · Updated Sep 25, 2026 · NCT06793397

Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression

RecruitingPhase 1Healthy volunteers welcome
  • Wells Medicine, Houston
  • Texas A&M (Houston Methodist Hospital Location), Houston
Ages 21 to 45 · All sexes · Updated Sep 15, 2026 · NCT06480201

Psilocybin-Assisted Psychotherapy in Patients With Advanced Cancer on Maintenance Therapy

RecruitingPhase 2
  • MD Anderson Cancer Center, Houston
Ages 25 and older · All sexes · Updated Sep 11, 2026 · NCT06200155

PCORI Comparative Effectiveness Study-Esketamine (Spravato) vs. Ketamine-Equivalence Study

RecruitingPhase 3
  • Houston Center for Advanced Psychiatric Treatment, Bellaire · 7 mi away
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT06713616

Neurodevelopmental Outcomes in Children: Strengthening the Caregiver-Child Story

RecruitingObservational studyHealthy volunteers welcome
  • Texas Children's Hospital, Houston
Ages 18 and older · All sexes · Updated Aug 31, 2026 · NCT05809115

Cognitive Training as an Adjunct to Ketamine in Real-world Clinics

Recruiting
  • Baylor College of Medicine, Houston
Ages 18 to 80 · All sexes · Updated Aug 19, 2026 · NCT06526078

TRIPS - Treatment to Improve Depression and/or Anxiety Using Psilocybin-assisted Psychotherapy in Cancer Survivors

RecruitingPhase 2
  • The University of Texas M. D. Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Aug 12, 2026 · NCT06801041

Bilateral Prefrontal and Insular TMS for Depression in Schizophrenia

Recruiting
  • The University of Texas Health Science Center at Houston, Houston
Ages 18 to 60 · All sexes · Updated Aug 5, 2026 · NCT07060066

Telehealth Behavioral Activation for Teens

Recruiting
  • Baylor College of Medicine, Houston
Ages 12 to 18 · All sexes · Updated Aug 4, 2026 · NCT06273995

A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.

RecruitingPhase 3
  • Kaleidoscope Clinical Research /ID# 277650, Houston
  • Houston Clinical Trials - Bellaire /ID# 274189, Bellaire · 7 mi away
Ages 10 to 17 · All sexes · Updated Jul 27, 2026 · NCT04777357

Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, Houston
  • Neurocrine Clinical Site, Bellaire · 7 mi away
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT06966401

A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression

Recruiting
  • The University Of Texas Medical School At Houston - UT Center Of Excellence On Mood Disorders, Houston
Ages 18 and older · All sexes · Updated Jun 15, 2026 · NCT03887715

Transcutaneous Vagus Nerve Stimulation for Attention and Memory

Recruiting
  • Michael E. DeBakey VA Medical Center, Houston
  • Michael E. DeBakey VA Medical Center, Houston
Ages 25 to 64 · All sexes · Updated May 7, 2026 · NCT06723743

Self Neuro-modulation Therapy for Major Depressive Disorder (MDD) With Anhedonia

Recruiting
  • Houston Center For Advanced Psychiatric Treatment, Houston
Ages 22 to 75 · All sexes · Updated May 1, 2026 · NCT06982820

Survivorship Care for Women Living With Ovarian Cancer: (POSTCARE-O)

Recruiting
  • Dan L Duncan Comprehensive Cancer Center at the O'Quinn Medical Tower at Baylor St. Luke's Medical Center, Houston
  • Harris Health Smith Clinic, Houston
Ages 18 and older · Women · Updated Apr 3, 2026 · NCT05752448

Intracranial Investigation of Neural Circuity Underlying Human Mood

Recruiting
  • Baylor College of Medicine, Houston
Ages 21 to 70 · All sexes · Updated Mar 4, 2026 · NCT05871372

Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, Houston
Ages 18 and older · All sexes · Updated Oct 29, 2025 · NCT06786624

Functional Connectivity Alterations in Suicidal Patients Among Opioid Users

RecruitingHealthy volunteers welcome
  • The Menninger Clinic, Houston
Ages 18 to 64 · All sexes · Updated Apr 4, 2025 · NCT05489042

About Depression

Depression is a serious medical illness. It affects almost 7 percent of U.S. adults. It causes feelings of sadness, hopelessness, and frustration that do not go away. Learn about treatments.

More about Depression on MedlinePlus

Depression trials in other cities

Other studies in Houston

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.