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Depression clinical trials in Atlanta, GA

23 studies for Depression are looking for participants at sites in and around Atlanta (within about 30 miles). Open a study to see who can join and how to contact the study team.

Regulated Stimulation for Optimized Network Activity and Therapeutic Equilibrium

Recruiting
  • Emory Healthcare, Atlanta
Ages 22 to 85 · All sexes · Updated Sep 29, 2026 · NCT07594483

JAK Signaling in Depression and Cognition in Male Football Players

RecruitingPhase 2Healthy volunteers welcome
  • Emory Clinic, Emory University Hospital, Atlanta
  • Emory School Of Medicine, Atlanta
  • Emory University, Atlanta
Ages 30 to 55 · Men · Updated Sep 24, 2026 · NCT07608796

Brexanolone Lifting Outcomes Of Moms

RecruitingPhase 3
  • Lipocine Investigational Site, Decatur · 6 mi away
Ages 15 to 45 · Women · Updated Sep 16, 2026 · NCT07822321

RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses

RecruitingPhase 2
  • Emory University, Atlanta
Ages 18 to 80 · All sexes · Updated Sep 15, 2026 · NCT07002034

A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)

RecruitingPhase 2
  • Seaport Investigator Site, Atlanta
  • Seaport Investigator Site, Decatur · 6 mi away
Ages 18 to 65 · All sexes · Updated Sep 14, 2026 · NCT07065240

A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3)

RecruitingPhase 3
  • Delricht Research, Atlanta
  • Emory University Brain Health Center, Atlanta
Ages 18 to 74 · All sexes · Updated Sep 8, 2026 · NCT07076407

PCORI Comparative Effectiveness Study-Esketamine (Spravato) vs. Ketamine-Equivalence Study

RecruitingPhase 3
  • Emory University, Atlanta
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT06713616

A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression

RecruitingPhase 2
  • Draig Clinical Site, Decatur · 6 mi away
Ages 18 to 75 · All sexes · Updated Sep 2, 2026 · NCT07610473

A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression

RecruitingPhase 2
  • Draig Clinical Site, Atlanta
  • Draig Clinical Site, Decatur · 6 mi away
Ages 18 to 75 · All sexes · Updated Aug 26, 2026 · NCT07300969

NBI-1065845-MDD3025: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, Atlanta
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT06911112

A Study of Brenipatide in Adult Participants With Major Depressive Disorder

RecruitingPhase 3
  • CenExel iResearch, LLC, Decatur · 6 mi away
Ages 18 to 75 · All sexes · Updated Aug 6, 2026 · NCT07412756

E-Mindfulness Approaches for Living After Breast Cancer

RecruitingPhase 3
  • Grady Health System, Atlanta
  • Emory University Hospital Midtown, Atlanta
  • Emory University Hospital/Winship Cancer Institute, Atlanta
  • and 2 more
Ages 18 to 50 · All sexes · Updated Aug 4, 2026 · NCT06748222

A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder

RecruitingPhase 3
  • Advanced Discovery Research, Atlanta
  • Synexus - Atlanta, Atlanta
Ages 18 to 74 · All sexes · Updated Aug 3, 2026 · NCT06775379

A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.

RecruitingPhase 3
  • CenExcel iResearch LLC /ID# 228695, Decatur · 6 mi away
  • Denali Health Atlanta, LLC /ID# 278167, Stone Mountain · 13 mi away
Ages 10 to 17 · All sexes · Updated Jul 27, 2026 · NCT04777357

Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, Atlanta
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT06966401

Mechanisms of Behavioral Activation (BA)

RecruitingHealthy volunteers welcome
  • Emory University, Atlanta
  • Facility for Education and Research in Neuroscience (FERN), Atlanta
  • Child and Adolescent Mood Program (CAMP), Atlanta
Ages 15 to 17 · All sexes · Updated Jun 1, 2026 · NCT05548244

Inflammation and Depression in People With HIV

RecruitingPhase 2
  • Grady Memorial Hospital, Atlanta
  • Emory University Hospital, Atlanta
Ages 18 to 65 · All sexes · Updated May 28, 2026 · NCT05849038

A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)

RecruitingPhase 2
  • CenExcel, Decatur · 6 mi away
Ages 18 to 65 · All sexes · Updated May 11, 2026 · NCT06524830

Dopaminergic Therapy for Anhedonia - 2

RecruitingPhase 4
  • Emory University Hospital, Atlanta
Ages 25 to 55 · All sexes · Updated Jan 28, 2026 · NCT06075771

Suicidal Behavior in Patients Diagnosed With Bipolar Disorder

Recruiting
  • Grady Health System, Atlanta
Ages 18 to 64 · All sexes · Updated Jan 7, 2026 · NCT02604277

Brain Stimulation and Decision-making

RecruitingHealthy volunteers welcome
  • Emory University, Atlanta
Ages 18 to 50 · All sexes · Updated Dec 10, 2025 · NCT04099056

A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms

RecruitingPhase 4
  • Clinical Research Site, Atlanta
Ages 18 to 65 · All sexes · Updated Jan 23, 2025 · NCT06223880

About Depression

Depression is a serious medical illness. It affects almost 7 percent of U.S. adults. It causes feelings of sadness, hopelessness, and frustration that do not go away. Learn about treatments.

More about Depression on MedlinePlus

Depression trials in other cities

Other studies in Atlanta

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.